| Project/Area Number |
20390380
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Cerebral neurosurgery
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| Research Institution | Hamamatsu University School of Medicine |
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Principal Investigator |
YAMAMOTO Seiji Hamamatsu University School of Medicine, 光量子医学研究センター, 准教授 (60144094)
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| Co-Investigator(Kenkyū-buntansha) |
IHARA Hayato 浜松医科大学, 医学部, 助教 (00223298)
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| Research Collaborator |
KOIZUMI Shinichro 浜松医科大学, 医学部, 大学院生
THURA Min 浜松医科大学, 光量子医学研究センター, 研究員
GOLANOV Eugene V , Neuroscience, Telemedicine & Advanced Technology Research Center, USA
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥18,070,000 (Direct Cost: ¥13,900,000、Indirect Cost: ¥4,170,000)
Fiscal Year 2010: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2009: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2008: ¥8,840,000 (Direct Cost: ¥6,800,000、Indirect Cost: ¥2,040,000)
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| Keywords | 脳血管障害 / 虚血耐性 / 脳電気刺激 / ミトコンドリア蛋白 / トランスレーショナルリサーチ / 脳神経疾患 / 共焦点顕微鏡 |
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| Research Abstract |
We tried to reveal the neuroprotective mechanisms induced by the electrical stimulation of cerebellar fastigial nucleus (FN) in rats. 1h-FN stimulation decreased, 72h later, the infarct volume by 22%. 1h-FN stimulation increased, 72h later, mRNA level of uncoupling protein 4 (UCP4), a mitochondria protein, to 160% in the brain. Intra-ventricular injection of siRNA decreased the UCP4 mRNA level, and tended to abolish the neuroprotection induced by FN stimulation. Following FN stimulation, up-regulation of UCP4 may be a component of the endogenous neuroprotective mechanisms.
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