Optimization of the host brain environment for the cell replacement therapy using ES cells
| Project/Area Number |
20390383
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Cerebral neurosurgery
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| Research Institution | Kyoto University |
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Principal Investigator |
TAKAHASHI Jun Kyoto University, 再生医科学研究所, 准教授 (10270779)
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| Co-Investigator(Kenkyū-buntansha) |
HASHIMOTO Nobuo 京都大学, 大学院・医学研究科, 教授 (40135570)
TAKAHASHI Ryosuke 京都大学, 大学院・医学研究科, 教授 (90216771)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥19,370,000 (Direct Cost: ¥14,900,000、Indirect Cost: ¥4,470,000)
Fiscal Year 2010: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2009: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2008: ¥8,190,000 (Direct Cost: ¥6,300,000、Indirect Cost: ¥1,890,000)
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| Keywords | 実験脳外科学 / ES細胞 / 神経分化 / 細胞移植 / 炎症 |
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| Research Abstract |
The final goal of this study was to optimize the host brain environment for the cell replacement therapy using ES cells. By this study, we have obtained the following results : 1) Single and local blockade of IL-6 signaling promoted neuronal differentiation of transplanted ES cell-derived neural precursor cells. 2) Systemic administration of CTLA4-Ig promoted neuronal differentiation of transplanted ES cell-derived neural precursor cells. 3) Nonhypotensive dose of Telmisartan attenuated cognitive impariment partially due to peroxisome proliferator-activated receptor-γ activation in mice with chronic cerebral hypoperfusion.
These results suggest that the host brain environment plays an important role in a transplantation of ES cell-derived neural cells, and also that we need to control the inflammation in the host brain for the efficient transplantation.
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Report
(4 results)
Research Products
(42 results)
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[Journal Article] Nonhypotensive Dose of Telmisartan Attenuates Cognitive Impariment Partially due to Peroxisome Proliferator-Activated Receptor-γ Activation in Mice with Chronic Cerebral Hypoperfusion.2010
Author(s)
Washida K, Ihara M, Nishio K, Fujita Y, Maki T, Yamada M, Takahashi J, Wu X, Kihara T, Ito H, Tomimoto H, Takahashi R.
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Journal Title
Stroke. 2010 41
Pages: 1798-1806
Related Report
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[Journal Article] Nonhypotensive dose of Telmisartan attenuates cognitive impairment partially due to peroxisome proliferator-activated receptor-γ activation in mice with chronic cerebral hypoperfusion.2010
Author(s)
Washida K, Ihara M, Nishio K, Fujita Y, Maki T, Yamada M, Takahashi J, Wu X, Kihara T, Ito H, Tomimoto H, Takahashi R.
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Journal Title
Stroke
Volume: 41
Pages: 1798-1806
Related Report
Peer Reviewed
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[Presentation] Nonhypotensive Dose of Telmisartan Attenuates Cognitive Impairment Partiyally Due to Peroxisome Proliferator-Activated-γ Activation in Mice With Chronic Cerebral Hypoperfusion.2010
Author(s)
Washida K, Ihara M, Nishio K, Fujita Y, Maki T, Yamada M, Takahashi J, Wu X, Kihara T, Ito H, Tomimoto H, Takahashi R.
Organizer
The 22^<nd> Annual Meeting of the Japanese Society of Cerebral Blood Flow and Metabolism
Place of Presentation
Osaka
Year and Date
2010-11-27
Related Report
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[Presentation] Nonhypotensive Dose of Telmisartan Attenuates Cognitive Impairment Partiyally Due to Peroxisome Proliferator-Activated-γ Activation in Mice With Chronic Cerebral Hypoperfusion.2010
Author(s)
Washida K, Ihara M, Nishio K, Fujita Y, Maki T, Yamada M, Takahashi J, Wu X, Kihara T, Ito H, Tomimoto H, Takahashi R.
Organizer
The 2^<nd> Kyoto Neuropathology Conference
Place of Presentation
Kyoto
Year and Date
2010-11-25
Related Report
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[Presentation] Nonhypotensive Dose of Telmisartan Attenuates Cognitive Impairment Partiyally Due to Peroxisome Proliferator-Activated-γ Activation in Mice With Chronic Cerebral Hypoperfusion.2010
Author(s)
Washida K, Ihara M, Nishio K, Fujita Y, Maki T, Yamada M, Takahashi J, Wu X, Kihara T, Ito H, Tomimoto H, Takahashi R.
Organizer
The 33^<rd> Annual Meeting of the Japan Neuroscience Society
Place of Presentation
Kobe
Year and Date
2010-09-19
Related Report
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[Presentation] Nonhypotensive Dose of Telmisartan Attenuates Cognitive Impairment Partiyally Due to Peroxisome Proliferator-Activated-γ Activation in Mice With Chronic Cerebral Hypoperfusion.2010
Author(s)
Washida K, Ihara M, Nishio K, Fujita Y, Maki T, Yamada M, Takahashi J, Wu X, Kihara T, Ito H, Tomimoto H, Takahashi R.
Organizer
The 1st Annual Neuroscience Conference
Place of Presentation
Nairobi, Kenya
Year and Date
2010-09-07
Related Report
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[Presentation] Nonhypotensive Dose of Telmisartan Attenuates Cognitive Impariment Partially due to PPAR-γ Activation in Mice with Chronic Cerebral Hypoperfusion.2010
Author(s)
Washida K, Ihara M, Nishio K, Fujita Y, Maki T, Yamada M, Takahashi J, Wu X, Kihara T, Ito H, Tomimoto H, Takahashi R.
Organizer
The 51^<st> Annual Meeting of Japanese Society of Neurology
Place of Presentation
Tokyo
Year and Date
2010-05-20
Related Report
-
[Presentation] Nonhypotensive Dose of Telmisartan Attenuates Cognitive Impariment Partially due to PPAR-γ Activation in Mice with Chronic Cerebral Hypoperfusion.2010
Author(s)
Washida K, Ihara M, Nishio K, Fujita Y, Maki T, Yamada M, Takahashi J, Wu X, Kihara T, Ito H, Tomimoto H, Takahashi R.
Organizer
The 35^<th> Japanese Congress of Stroke
Place of Presentation
morioka
Year and Date
2010-04-16
Related Report
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