| Budget Amount *help |
¥19,370,000 (Direct Cost: ¥14,900,000、Indirect Cost: ¥4,470,000)
Fiscal Year 2010: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2009: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2008: ¥8,190,000 (Direct Cost: ¥6,300,000、Indirect Cost: ¥1,890,000)
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| Research Abstract |
The final goal of this study was to optimize the host brain environment for the cell replacement therapy using ES cells. By this study, we have obtained the following results : 1) Single and local blockade of IL-6 signaling promoted neuronal differentiation of transplanted ES cell-derived neural precursor cells. 2) Systemic administration of CTLA4-Ig promoted neuronal differentiation of transplanted ES cell-derived neural precursor cells. 3) Nonhypotensive dose of Telmisartan attenuated cognitive impariment partially due to peroxisome proliferator-activated receptor-γ activation in mice with chronic cerebral hypoperfusion.
These results suggest that the host brain environment plays an important role in a transplantation of ES cell-derived neural cells, and also that we need to control the inflammation in the host brain for the efficient transplantation.
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