Role of the parafascicular-striatal projection in the anti-depressive effect of vagal nerve stimulation

• Project/Area Number: 20390385
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Cerebral neurosurgery
• Research Institution: Shimane University
• Principal Investigator: ITO Shin-Ichi Shimane University, 医学部, 准教授 (10145295)
• Co-Investigator(Kenkyū-buntansha): TAKADA Kohji 帝京大学, 文学部, 教授 (70100930)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥19,370,000 (Direct Cost: ¥14,900,000、Indirect Cost: ¥4,470,000); Fiscal Year 2010: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2009: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000); Fiscal Year 2008: ¥9,620,000 (Direct Cost: ¥7,400,000、Indirect Cost: ¥2,220,000)
• Keywords: 迷走神経刺激 / カフ電極 / 視床束傍核 / 強制水泳 / 恐怖条件付け / 抗うつ効果 / 抗不安効果 / 逆行性標識 / 破壊実験 / 迷走神経求心線維 / 強制水泳試験 / 学習性無力 / 社会性ストレス / 抗うつ作用 / 大脳基底核 / 埋め込み電極

Research Abstract

A new implantable cuff electrode for vagus nerve stimulation (VNS) was developed. VNS was found to be effective to the treatment-resistant depression model based on fear conditioning. It was found that vagus input to the thalamic parafascicular nucleus was transmitted via medial subnucleus of the ipsilateral parabrachial nucleus. Effects of parafascicular lesion on the anti-depressant VNS effect is under investigation.

Research Products

• [Journal Article] 神経毒性試験 (2008)
  • Author(s): 高橋宏明、高田孝二
  • Journal Title: 日本薬理学雑誌 131 Pages: 462-467
  • NAID: 10024383180
  • Peer Reviewed
• [Presentation] Cognitive drug safety -a translational approach. (2010)
  • Author(s): Takada K, Watanabe, S
  • Organizer: 日本薬理学会第83回年会シンポジウム
  • Place of Presentation: 横浜
  • Year and Date: 2010-03-16
• [Presentation] Thalamic sites projecting to the vagal-responsive region in the insular and sensorimotor cortex in rats (2009)
  • Author(s): Ito S
  • Organizer: 北米神経科学会
  • Place of Presentation: シカゴ
  • Year and Date: 2009-10-18
• [Presentation] Projection of slow-conducting somatic afferents to the visceral representing region in the rat sensorimotor cortex (2009)
  • Author(s): Ito S
  • Organizer: 日本神経科学学会第32回大会
  • Place of Presentation: 名古屋
  • Year and Date: 2009-09-17
• [Presentation] Thalamocortical projections of the vagus-responsive region of the basal part of the ventral medial nucleus in monkeys (2009)
  • Author(s): Ito S
  • Organizer: 国際生理学会第36回大会
  • Place of Presentation: 京都
  • Year and Date: 2009-07-30
• [Presentation] Thalamocortical projections of the vagus-responsive region of the basal part of the ventral medial nucleus in monkeys (2008)
  • Author(s): Ito S, Craig AD
  • Organizer: 北米神経科学会
  • Place of Presentation: ワシントン
  • Year and Date: 2008-11-17
• [Presentation] Thalamocortical projections of the vagus-responsive region of the basal part of the ventral medial nucleus in monkeys (2008)
  • Author(s): Ito S, Craig AD
  • Organizer: Society for Neuroscience
  • Place of Presentation: Washington, DC, USA
  • Year and Date: 2008-11-17
• [Presentation] 健常者における音刺激による驚愕反応と不安感との関連 (2008)
  • Author(s): 久保位可子, 橋倉都, 堀弘明, 尾関祐二, 廣中直行, 高田孝二, 功刀浩
  • Organizer: 第30回日本生物学的精神医学会
  • Place of Presentation: 富山
  • Year and Date: 2008-09-11
• [Presentation] Vagal visceral sensory input to the basal ganglia (2008)
  • Author(s): Ito S
  • Organizer: 日本神経消化器病学会シンポジウム
  • Place of Presentation: 福岡
  • Year and Date: 2008-05-11
• [Remarks] ホームページ等
• [Patent(Industrial Property Rights)] カフ電極 (2010)
  • Inventor(s): 伊藤眞一
  • Industrial Property Rights Holder: 伊藤眞一
  • Filing Date: 2010-10-01
• [Patent(Industrial Property Rights)] カフ電極 (2010)
  • Inventor(s): 伊藤眞一
  • Industrial Property Rights Holder: 伊藤眞一
  • Filing Date: 2010-10-01