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Role of the parafascicular-striatal projection in the anti-depressive effect of vagal nerve stimulation

Research Project

Project/Area Number 20390385
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Cerebral neurosurgery
Research InstitutionShimane University

Principal Investigator

ITO Shin-Ichi  Shimane University, 医学部, 准教授 (10145295)

Co-Investigator(Kenkyū-buntansha) TAKADA Kohji  帝京大学, 文学部, 教授 (70100930)
Project Period (FY) 2008 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥19,370,000 (Direct Cost: ¥14,900,000、Indirect Cost: ¥4,470,000)
Fiscal Year 2010: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2009: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2008: ¥9,620,000 (Direct Cost: ¥7,400,000、Indirect Cost: ¥2,220,000)
Keywords迷走神経刺激 / カフ電極 / 視床束傍核 / 強制水泳 / 恐怖条件付け / 抗うつ効果 / 抗不安効果 / 逆行性標識 / 破壊実験 / 迷走神経求心線維 / 強制水泳試験 / 学習性無力 / 社会性ストレス / 抗うつ作用 / 大脳基底核 / 埋め込み電極
Research Abstract

A new implantable cuff electrode for vagus nerve stimulation (VNS) was developed. VNS was found to be effective to the treatment-resistant depression model based on fear conditioning. It was found that vagus input to the thalamic parafascicular nucleus was transmitted via medial subnucleus of the ipsilateral parabrachial nucleus. Effects of parafascicular lesion on the anti-depressant VNS effect is under investigation.

Report

(4 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (12 results)

All 2010 2009 2008 Other

All Journal Article (1 results) (of which Peer Reviewed: 1 results) Presentation (8 results) Remarks (1 results) Patent(Industrial Property Rights) (2 results)

  • [Journal Article] 神経毒性試験2008

    • Author(s)
      高橋宏明、高田孝二
    • Journal Title

      日本薬理学雑誌 131

      Pages: 462-467

    • NAID

      10024383180

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Presentation] Cognitive drug safety -a translational approach.2010

    • Author(s)
      Takada K, Watanabe, S
    • Organizer
      日本薬理学会第83回年会シンポジウム
    • Place of Presentation
      横浜
    • Year and Date
      2010-03-16
    • Related Report
      2010 Final Research Report
  • [Presentation] Thalamic sites projecting to the vagal-responsive region in the insular and sensorimotor cortex in rats2009

    • Author(s)
      Ito S
    • Organizer
      北米神経科学会
    • Place of Presentation
      シカゴ
    • Year and Date
      2009-10-18
    • Related Report
      2010 Final Research Report
  • [Presentation] Projection of slow-conducting somatic afferents to the visceral representing region in the rat sensorimotor cortex2009

    • Author(s)
      Ito S
    • Organizer
      日本神経科学学会第32回大会
    • Place of Presentation
      名古屋
    • Year and Date
      2009-09-17
    • Related Report
      2010 Final Research Report
  • [Presentation] Thalamocortical projections of the vagus-responsive region of the basal part of the ventral medial nucleus in monkeys2009

    • Author(s)
      Ito S
    • Organizer
      国際生理学会第36回大会
    • Place of Presentation
      京都
    • Year and Date
      2009-07-30
    • Related Report
      2010 Final Research Report
  • [Presentation] Thalamocortical projections of the vagus-responsive region of the basal part of the ventral medial nucleus in monkeys2008

    • Author(s)
      Ito S, Craig AD
    • Organizer
      北米神経科学会
    • Place of Presentation
      ワシントン
    • Year and Date
      2008-11-17
    • Related Report
      2010 Final Research Report
  • [Presentation] Thalamocortical projections of the vagus-responsive region of the basal part of the ventral medial nucleus in monkeys2008

    • Author(s)
      Ito S, Craig AD
    • Organizer
      Society for Neuroscience
    • Place of Presentation
      Washington, DC, USA
    • Year and Date
      2008-11-17
    • Related Report
      2008 Annual Research Report
  • [Presentation] 健常者における音刺激による驚愕反応と不安感との関連2008

    • Author(s)
      久保位可子, 橋倉都, 堀弘明, 尾関祐二, 廣中直行, 高田孝二, 功刀浩
    • Organizer
      第30回日本生物学的精神医学会
    • Place of Presentation
      富山
    • Year and Date
      2008-09-11
    • Related Report
      2010 Final Research Report
  • [Presentation] Vagal visceral sensory input to the basal ganglia2008

    • Author(s)
      Ito S
    • Organizer
      日本神経消化器病学会シンポジウム
    • Place of Presentation
      福岡
    • Year and Date
      2008-05-11
    • Related Report
      2010 Final Research Report
  • [Remarks] ホームページ等

    • Related Report
      2010 Final Research Report
  • [Patent(Industrial Property Rights)] カフ電極2010

    • Inventor(s)
      伊藤眞一
    • Industrial Property Rights Holder
      伊藤眞一
    • Filing Date
      2010-10-01
    • Related Report
      2010 Final Research Report
  • [Patent(Industrial Property Rights)] カフ電極2010

    • Inventor(s)
      伊藤眞一
    • Industrial Property Rights Holder
      伊藤眞一
    • Filing Date
      2010-10-01
    • Related Report
      2010 Annual Research Report

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Published: 2008-04-01   Modified: 2016-04-21  

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