Identification of neural induction domain in stem cells and neuronal regenerative medicine using the peptide derived from the domain
| Project/Area Number |
20390389
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Cerebral neurosurgery
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| Research Institution | Yokohama City University |
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Principal Investigator |
KANNO Hiroshi Yokohama City University, 医学部, 准教授 (40244496)
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| Co-Investigator(Kenkyū-buntansha) |
SAITO Tomoyuki 横浜市立大学, 医学研究科, 教授 (30170517)
ITO Norihiko 横浜市立大学, 医学部, 助教 (80264654)
MIZUKI Nobuhisa 横浜市立大学, 医学研究科, 教授 (90336579)
DEZAWA Mari 東北大学, 大学院・医学研究科, 教授 (50272323)
味村 俊郎 横浜市立大学, 医学研究科, 客員研究員 (50336583)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥19,110,000 (Direct Cost: ¥14,700,000、Indirect Cost: ¥4,410,000)
Fiscal Year 2010: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2009: ¥7,150,000 (Direct Cost: ¥5,500,000、Indirect Cost: ¥1,650,000)
Fiscal Year 2008: ¥6,760,000 (Direct Cost: ¥5,200,000、Indirect Cost: ¥1,560,000)
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| Keywords | 神経再生 / 幹細胞 / 神経分化ペプチド / 脊髄再生 / パーキンソン病 / VHL / 機能性ペプチド / 多能性幹細胞 / 神経再生医療 / 神経幹細胞 / 皮膚由来幹細胞 / 脊髄損傷 / 皮膚幹細胞 |
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| Research Abstract |
We identified a neural induction domain for somatic stem cells at elonign BC binding site in the VHL protein, and show neuronal differentiation of the cells by transfer of the domain peptide linked to protein transduction domain (PTD). In addition, we show that the domain has the same function for the other somatic stem cells, and that BC-box motifs within SOCS-box proteins also have an ability to induce neuronal differentiation. Furthermore, when the domain peptide-transferred stem cells are grafted into recipient nervous tissue, the grafted cells differentiate to neurons and recovery of the neuronal symptom is recognized. Thus, the neuronal differentiation of pluripotent somatic stem cells is occurred by transfer of the neural induction domain peptide linked to PTD and would contribute to neuronal regenerative therapy.
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Report
(4 results)
Research Products
(30 results)
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[Journal Article] Human umbilical cord-derived mesenchymal stromal cells differentiate into functional Schwann cells that sustain peripheral nerve regeneration.2010
Author(s)
Matsuse D, Kitada M, Kohama M, Nishikawa K, Makinoshima H, Wakao S, Fujiyoshi Y, Heike T, Nakahata T, Akutsu H, Umezawa A, Harigae H, Kira J, Dezawa M.
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Journal Title
Neuropathol Exp Neurol. 69(9)
Pages: 973-985
NAID
Related Report
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[Journal Article] Long-term observation of auto-cell transplantation in non-human primate reveals safety and efficiency of bone marrow stromal cell-derived Schwann cells in peripheral nerve regeneration.2010
Author(s)
Wakao S, Hayashi T, Kitada M, Kohama M, Matsue D, Teramoto N, Ose T, Itokazu Y, Koshino K, Watabe H, Iida H, Takamoto T, Tabata Y, Dezawa M.
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Journal Title
Exp Neurol. 223(2)
Pages: 537-547
Related Report
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[Journal Article] Unique multipotent cells in adult human mesenchymal cell populations.2010
Author(s)
Kuroda Y, Kitada M, Wakao S, Nishikawa K, Tanimura Y, Makinoshima H, Goda M, Akashi H, Inutsuka A, Niwa A, Shigemoto T, Nabeshima Y, Nakahata T, Nabeshima Y, Fujiyoshi Y, Dezawa M.
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Journal Title
Proc Natl Acad Sci USA. 107(19)
Pages: 8639-8643
Related Report
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