| Budget Amount *help |
¥19,370,000 (Direct Cost: ¥14,900,000、Indirect Cost: ¥4,470,000)
Fiscal Year 2010: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2009: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2008: ¥8,190,000 (Direct Cost: ¥6,300,000、Indirect Cost: ¥1,890,000)
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| Research Abstract |
To regenerate a defect of weight-bearing bone, we developed a composite hydroxyapatite combined with a compact (500MPa) and a porous (10MPa) parts, by adopting the "form-gel" technique. The bone substitute combined with recombinant human bone morphogenetic protein-7 (OP-1) completely repaired the cartilage and subchondral bone defect of rabbit and pig femurs, and must be a promising candidate for joint regeneration.
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