| Budget Amount *help |
¥19,630,000 (Direct Cost: ¥15,100,000、Indirect Cost: ¥4,530,000)
Fiscal Year 2010: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2009: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2008: ¥10,270,000 (Direct Cost: ¥7,900,000、Indirect Cost: ¥2,370,000)
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| Research Abstract |
We analyzed ADAMTS9 single nucleotide polymorphism in arthritis patients. We identified the NF-κB binding to the ADAMTS9 promoter. When mechanical stress was loaded to the cells, the expression of ADAMTS1, 4, 5, 9 were differently induced. In addition, COL1A1 was increased and this induction was mediated by integrin. Mechanical stress induced MMP-13 and ADAMTS5 mRNA and two molecules (RUNX-2 and p38MAPK) play important roles.
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