| Budget Amount *help |
¥9,750,000 (Direct Cost: ¥7,500,000、Indirect Cost: ¥2,250,000)
Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2009: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2008: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
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| Research Abstract |
Osteosarcoma is the most common primary solid tumor of bone, which can be characterized by a high level of genetic instability and rarely resistanct to conventional treatments. This study focused on the chromosome aberrations and the changes of gene expressions influencing on the specific tumor site, the histopathological subtypes, and the prognosis. We hypothesized that the DNA copy number changes in the domain of chromosomal instability may be related to the tumorigenesis of osteosarcoma. The chromosomal instabilities of osteosarcoma were studied using the array CGH method for each age and location. We identified that there were more DNA deletion in extremities patients than in trunk patients. We detected several gene regions which may lead to different biological tumorigenic process between young and elderly patients.
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