Enhancement of bone healing during distraction osteogenesis
| Project/Area Number |
20390401
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (B)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Orthopaedic surgery
|
|---|
| Research Institution | The University of Tokushima |
|---|
Principal Investigator |
YASUI Natsuo The University of Tokushima, 大学院・ヘルスバイオサイエンス研究部, 教授 (00157984)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
TAKATA Shinjiro 徳島大学, 病院, 准教授 (20284292)
MATSUURA Tetsuya 徳島大学, 病院, 講師 (30359913)
NIKAWA Takeshi 徳島大学, 大学院・ヘルスバイオサイエンス研究部, 教授 (20263824)
TAKAHASHI Mitsuhiko 徳島大学, 大学院・ヘルスバイオサイエンス研究部, 講師 (10372715)
SAIRYO Koichi 徳島大学, 大学院・ヘルスバイオサイエンス研究部, 講師 (10304528)
|
|---|
| Project Period (FY) |
2008 – 2010
|
| Project Status |
Completed (Fiscal Year 2010)
|
| Budget Amount *help |
¥19,760,000 (Direct Cost: ¥15,200,000、Indirect Cost: ¥4,560,000)
Fiscal Year 2010: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2009: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2008: ¥11,960,000 (Direct Cost: ¥9,200,000、Indirect Cost: ¥2,760,000)
|
|---|
| Keywords | 仮骨延長 / 骨成長因子 / 持続投与 / distraction / osteogenesis / osteoenesis |
|---|
| Research Abstract |
Rabbit tibial lengthening was achieved to examine the effect of local infusion of the growth factors and bisphosphonate into the lengthened segment. When FGF-2 and bisphosphonate were infused simultaneously during consolidation phase, bone healing was dramatically enhanced. FGF-2 stimulated bone formation while bisphosphonate inhibited bone resorption. We believe this method is valid to shorten the treatment time of limb lengthening and is applicable in the clinical field as a new drug delivery system.
|
Report
(4 results)
Research Products
(38 results)
-
[Journal Article] Association study of TRAF1-C5 polymorphisms with susceptibility to rheumatoid arthritis and systemic lupus erythematosus in Japanese.2010
Author(s)
Nishimoto K, Kochi Y, Ikari K, Yamamoto K, Suzuki A, Shimane K, Nakamura Y, Yano K, Iikuni N, Tsukahara S, Kamatani N, Okamoto H, Kaneko H, Kawaguchi Y, Hara M, Toyama Y, Horiuchi T, Tao K, Yasutomo K, Hamada D, Yasui N, Inoue H, Itakura M, Yamanaka H, Momohara S
-
Journal Title
Ann Rheum Dis 69(2)
Pages: 368-373
Related Report
Peer Reviewed
-
[Journal Article] Specificity of fusion genes in adipocytic tumors.2010
Author(s)
Kubo T, Matsui Y, Naka N, Araki N, Myoui A, Endo K, Yasui N, Ohtani O, Suzuki K, Kimura T, Yoshikawa H, Ueda T
-
Journal Title
Anticancer Res 30
Pages: 661-664
Related Report
Peer Reviewed
-
-
-
-
-
-
-
-
-
-
-
[Journal Article] Ubiquitin Ligase Cbl-b Is a Negative Regulator for Insulin-Like Growth Factor 1 Signaling during Muscle Atrophy Caused by Unloading.2009
Author(s)
Nakao R, Hirasaka K, Goto J, Ishidoh K, Yamada C, Ohno A, Okumura Y, Nonaka I, Yasutomo K, Baldwin KM, Kominami E, Higashibata A, Nagano K, Tanaka K, Yasui N, Mills EM, Takeda S, Nikawa T
-
Journal Title
Mol Cell Biol 29(17)
Pages: 4798-4811
Related Report
Peer Reviewed
-
-
-
-
-
-
[Journal Article] Altered fracture callus formation in chondromodulin-I deficient mice.2008
Author(s)
Yukata K, Matsui Y, Shukunami C, Takimoto A, Goto T, Nishizaki Y, Nakamichi Y, Kubo T, Sano T, Kato S, Hiraki Y, Yasui N
-
Journal Title
Bone 43(2)
Pages: 1047-1056
Related Report
Peer Reviewed
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
