| Project/Area Number |
20390402
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Orthopaedic surgery
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| Research Institution | Oita University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
MATSUO Noritaka 大分大学, 医学部, 准教授 (10284788)
SUMIYOSHI Hideaki 大分大学, 医学部, 助教 (60343357)
HAMANAKA Ryoji 大分大学, 医学部, 助教 (60274750)
NINOMIYA Yoshifumi 岡山大学, 医歯薬学総合研究科, 教授 (70126241)
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| Project Period (FY) |
2008 – 2010
|
| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥19,890,000 (Direct Cost: ¥15,300,000、Indirect Cost: ¥4,590,000)
Fiscal Year 2010: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2009: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2008: ¥12,350,000 (Direct Cost: ¥9,500,000、Indirect Cost: ¥2,850,000)
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| Keywords | 骨 / 軟骨代謝学 / コラーゲン / 遺伝子発現 / 軟骨 / 細胞外マトリックス / 転写調節 / 筋 / 歯牙 / 転写調節機構 |
|---|
| Research Abstract |
Type V/XI collagen is essential for fibrogenesis. It consists of six α chains, of which expression are restrictedly regulated temporally and spaciously. In present project, we clarified the basal promoter region of α1(V) and α3(V) collagen genes in osteoblastic cells and α2(XI) collagen gene in odontoblastic cells. We also identified the binding site of osteoblast differential factor, Sp7/Osterix, in the promoter of α1(V) and α3(V) collagen genes. Furthermore, we showed the expression pattern of the α chains using wound healing model.
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