Development of peptide vaccination targeting novel musculoskeletal sarcoma antigens

• Project/Area Number: 20390403
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Orthopaedic surgery
• Research Institution: Sapporo Medical University
• Principal Investigator: WADA Takuro 札幌医科大学, 道民医療推進学講座, 特任教授 (00244369)
• Co-Investigator(Kenkyū-buntansha): YMASHITA Toshihiko 札幌医科大学, 医学部, 教授 (70244366) ; SATO Noriyuki 札幌医科大学, 医学部, 教授 (50158937)
• Project Period (FY): 2008 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥19,500,000 (Direct Cost: ¥15,000,000、Indirect Cost: ¥4,500,000); Fiscal Year 2011: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000); Fiscal Year 2010: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000); Fiscal Year 2009: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000); Fiscal Year 2008: ¥9,230,000 (Direct Cost: ¥7,100,000、Indirect Cost: ¥2,130,000)
• Keywords: 分子標的治療 / 骨軟部肉腫 / 癌ワクチン / ペプチド / 骨肉腫 / 滑膜肉腫 / ペプチドワクチン / 癌免疫 / 腫瘍抗原 / 幹細胞 / 融合遺伝子 / 類上皮肉腫 / 肉腫幹細胞 / SYT-SSX / PBF / 癌抗原 / 細胞傷害性T細胞 / 肉腫幹細胞抗原 / ノックアウトマウス / ペプチドワクチン療法 / 第1相臨床試験 / 癌幹細胞 / 細胞傷害性Tリンパ球 / 悪性線維性組織球腫

Research Abstract

We performed phase I clinical peptide vaccination trials for patients with disseminated synovial sarcoma or osteosarcoma. For synovial sarcoma, the trial was completed and the safety and efficacy of SYT-SSX peptide vaccination was confirmed. For osteosarcoma, the trial is continued.
We identified cancer-stem like cells from malignant fibrous histiocytoma of the bone and epithelial sarcoma. Furthermore, we established autologous cytotoxic T-lymphocyte clone recognizing cancer-stem like cells in the context of HLA class I. These observations open the door toward immunotherapy targeting cancer-stem like cells.

Research Products

• [Journal Article] Prognostic significance of HLA class I expression in Ewing's sarcoma family of tumors (2011)
  • Author(s): Yabe H, Tsukahara T, Kawaguchi S, Wada T, Torigoe T, Sato N, Terai C, Aoki M, Hirose S, Morioka H, Yabe H
  • Journal Title: J Surg Oncol Volume: 103 Pages: 380-385
  • Peer Reviewed
• [Journal Article] Autologous CTL response against cancer stem-like cells/cacer-initiating cells of bone malignant fibrous histiocytoma (2011)
  • Author(s): Kano M, Tsukahara T, Emori M, Masaki Murase, Torigoe T, Kawaguchi S, Wada T, Yamashita T, Sato N
  • Journal Title: Cancer Sci Volume: 102 Pages: 1443-1447
  • Peer Reviewed
• [Journal Article] Bone and/or joint attachment is a risk factor for local recurrence of myxofibrosarcoma (2011)
  • Author(s): Kaya M, Wada T, et al
  • Journal Title: J Orthop Sci Volume: 16 Issue: 4 Pages: 413-417
  • DOI: 10.1007/s00776-011-0100-0
  • NAID: 10029573954
  • Peer Reviewed
• [Journal Article] 骨・軟部肉腫に対するペプチドワクチン療法 (2011)
  • Author(s): 江森誠人, 和田卓郎, 他
  • Journal Title: 日本臨床 Volume: 69 Pages: 1670-1673
• [Journal Article] Angiomatoid fibrous histiocytoma including cases with pleomorphic features analysed by fluorescence in situ hybridisation. (2010)
  • Author(s): Matsumura T, Wada T, et al.
  • Journal Title: J Clin Pathol Volume: 63 Pages: 124-128
  • Peer Reviewed
• [Journal Article] Giant cell tumor of the sacrum treated with selective arterial embolization. (2010)
  • Author(s): Onishi H, Wada T, et al.
  • Journal Title: Int J Clin Oncol, 2010 Volume: 15 Pages: 416-419
  • NAID: 10026601549
  • Peer Reviewed
• [Journal Article] 骨・軟部肉腫のペプチドワクチン療法 (2010)
  • Author(s): 川口哲, 和田卓郎
  • Journal Title: 整形外科 Volume: 61 Pages: 714-719
• [Journal Article] Prognostic significance of HLA Class I expression in ewing's sarcoma familiy of tumors. (2010)
  • Author(s): Yabe H, Wada T, et al.
  • Journal Title: J Surg Oncol
  • Peer Reviewed
• [Journal Article] 小児肩周囲の骨腫瘍 (2010)
  • Author(s): 和田卓郎, 加谷光規, 他
  • Journal Title: 臨整外 Volume: 45 Pages: 1105-1109
• [Journal Article] Side population cells have the characteristics of cancer stem-like cells/cancer-initiating cells in bone sarcomas (2009)
  • Author(s): Murase M, Kano M, Tsukahara T, Takahashi A, Torigoe T, Kawaguchi S, Kimura S, Wada T, Uchihashi Y, Kondo T, Yamashita T, Sato N
  • Journal Title: Br J Cancer Volume: 101 Pages: 1425-1432
  • Peer Reviewed
• [Journal Article] Scythe/BAT3 regulates apoptotic cell death induced by papillomavirus binding factor in human osteosarcoma (2009)
  • Author(s): Tsukahara T, Kimura S, Ichimiya S, Torigoe T, Kawaguchi S, Wada T, Yamashita T, Sato N
  • Journal Title: Cancer Sci Volume: 100 Pages: 47-53
  • NAID: 10025141244
  • Peer Reviewed
• [Journal Article] HLA-A 0201-restricted CTL epitope of a novel osteosarcoma antigen, papillomavirus binding factor. (2009)
  • Author(s): Tsukahara T, Kawaguchi S, Torigoe T, Murase M, Wada T, Kaya M, Nagoya S, Yamashita T, Sato N
  • Journal Title: J Transl Med
  • Peer Reviewed
• [Journal Article] Scythe/BAT 3 regulates apoptotic cell death in duced by papillomavirus binding fac tor in human osteosarcom (2009)
  • Author(s): Tsukahara T, Wada T, et al
  • Journal Title: Cancer Sci 100 Pages: 47-53
  • Peer Reviewed
• [Journal Article] HLA-A*0201-restricted CLT epitope of a novel osteosarcoma antigen, papillomavirus binding factor (2009)
  • Author(s): Tsukahara T, Wada T, et al
  • Journal Title: J Transl Med 7 Pages: 77-77
  • Peer Reviewed
• [Journal Article] Side populati on cells have the characteristics of cancer stem-like cells/cancer-ini tiating cells in bone sarcomas (2009)
  • Author(s): Tsukahara T, Wada T, et al
  • Journal Title: Br J Cancer 101 Pages: 1425-1432
  • Peer Reviewed
• [Journal Article] Scythe/BAT3 regulates apoptotic cell death induced by papillomavirus binding factor in human osteosarcoma (2009)
  • Author(s): Tsukahara, Wada, et al.
  • Journal Title: Cancer Sci 100 Pages: 47-53
  • NAID: 10025141244
  • Peer Reviewed
• [Journal Article] HLA-A*0201-restricted CTL epitope of a novel osteosarcoma antigen, papillomavirus binding factor (2009)
  • Author(s): Tsukahara, Wada, et al.
  • Journal Title: J Trawl Med 7 Pages: 44-44
  • Peer Reviewed
• [Journal Article] Side population cells have the characteristics of cancer stem-like cells/cancer-initiating cells in bone sarcomas (2009)
  • Author(s): Murase, Wada, et al.
  • Journal Title: Br J Cancer 101 Pages: 1425-1432
  • Peer Reviewed
• [Journal Article] The level of vascular endothelial growth factor as a predictor of a poor prognosis in osteosarcoma (2009)
  • Author(s): Kaya M, Wada T, et al.
  • Journal Title: J Bone Joint Surg Br 91 Pages: 784-788
  • Peer Reviewed
• [Journal Article] Osteosarcoma in the elderly over 60 years : a multicenter study by the Japanese Musculoskeletal Oncology Group (2009)
  • Author(s): Nishida Y, Wada T, et al.
  • Journal Title: Journal of surgical oncology 100 Pages: 48-54
  • Peer Reviewed
• [Journal Article] 手部に発生した蔓状線維組織球腫の1例 (2009)
  • Author(s): 瀧村浩介, 和田卓郎, 他
  • Journal Title: 北海道整災外 51 Pages: 83-85
  • Peer Reviewed
• [Journal Article] 骨 Paget 病に続発した二次性骨肉腫の1例 (2009)
  • Author(s): 柏隆史, 和田卓郎, 他
  • Journal Title: 北海道整災外 51 Pages: 80-85
  • Peer Reviewed
• [Journal Article] Overexpression of papillomavirus binding factor in Ewing's sarcoma family of tumors conferring poor prognosis (2008)
  • Author(s): Yabe H, Tsukahara T, Kawaguchi S, Wada T, Sato N, Morioka H, Yabe H
  • Journal Title: Oncol Rep Volume: 19 Pages: 129-134
  • Peer Reviewed
• [Journal Article] Clonal T-cell response against autologous pleomorphic malignant fibrous histiocytoma antigen presented by retrieved HLA-A (2008)
  • Author(s): Kimura S, Kozakai Y, Kawaguchi S, Tsukahara T, Ida K, Murase M, Matsumura T, Kaya M, Torigoe T, Wada T, Sato N, Yamashita T
  • Journal Title: J Orthop Res Volume: 26 Pages: 271-278
  • Peer Reviewed
• [Journal Article] Antigenic peptide vaccination : Provoking immune response and clinical benefit for cancer (2008)
  • Author(s): Tsukahara T, Torigoe T, Tamura Y, Wada T, Kawaguchi S, Tsuruma T, Hirata K, Yamashita T, Sato N
  • Journal Title: Curr Immunol Rev Pages: 235-241
  • Peer Reviewed
• [Journal Article] Prognostic impact and immunogenicity of a novel osteosarcoma antigen, papillomavirus binding factor, in patients with osteosarcoma. (2008)
  • Author(s): Tsukahara T, Kawaguchi S, Torigoe T, Kimura S, Murase M, Ichimiya S, Wada T, Kaya M, Nagoya S, Ishii T, Tatezaki S, Yamashita T, Sato N
  • Journal Title: Cancer Sci Volume: 99 Pages: 368-375
  • NAID: 10024002681
  • Peer Reviewed
• [Journal Article] Prognostic impact and immunogenicity of a novel osteosarcoma antigen, papillomavirus binding factor, in patients with osteosarcoma (2008)
  • Author(s): Tsukahara T, Wada T, et al
  • Journal Title: Cancer Sci 99 Pages: 268-375
  • NAID: 10024002681
  • Peer Reviewed
• [Journal Article] Clonal T-cell response against autologous pleomo rphic malignant fibrous histiocytom a antigen presented by retrieved HLA-A*02 (2008)
  • Author(s): Kimura S, Wada T, et al
  • Journal Title: J Orthop Res Pages: 271-278
  • Peer Reviewed
• [Journal Article] Overexpression of papillomavirus binding factor in Ewing's sarcoma family of tumors conferring poor prognosis. (2008)
  • Author(s): Yabe H, et al.
  • Journal Title: Oncology reports 19 Pages: 129-34
  • Peer Reviewed
• [Journal Article] Prognostic impact and immunogenicity of a novel osteosarcoma antigen, papillomavirus binding factor, in patients with osteosarcoma. (2008)
  • Author(s): Tsukahara T, et al.
  • Journal Title: Cancer Sci 99 Pages: 368-75
  • Peer Reviewed
• [Journal Article] Antigenie peptide vaccination : Provoking immune response and clinical benefit for cancer (2008)
  • Author(s): Tsukahara T, et al.
  • Journal Title: Current Immunology Reviews 4 Pages: 235-241
  • Peer Reviewed
• [Journal Article] Advantage of FISH analysis using FKHR probes for an adjunct to diagnosis of rhabdomyosarcomas. (2008)
  • Author(s): Matsumura T, et al.
  • Journal Title: Virchows Arch 452 Pages: 251-8
  • Peer Reviewed
• [Journal Article] Clonal T-cell response against autologous pleomorphic malignant fibrous hist iocytoma antigen presented by retrieved HLA-A*0206. (2008)
  • Author(s): Kimura S, et al.
  • Journal Title: J Orthop Res 26 Pages: 271-8
  • Peer Reviewed
• [Journal Article] Prognostic implication of SYT-SSX fusion type in synovial sarcoma : A multi-institutional retrospective analysis in Japan. (2008)
  • Author(s): Takenaka S, et al.
  • Journal Title: Oncology reports 19 Pages: 467-76
  • Peer Reviewed
• [Journal Article] ペプチドワクチン療法 (2008)
  • Author(s): 塚原智英, 他
  • Journal Title: 整形外科 59 Pages: 1334-1334
• [Presentation] Generation of TCR-like antibody against HLA/peptide complex of an osteosarcoma antigen PBF「ワークショップ48:がん免疫療法」 (2011)
  • Author(s): 塚原智英, 和田卓郎, 他
  • Organizer: 第40回日本免疫学会総会
  • Place of Presentation: 千葉市
  • Year and Date: 2011-11-29
• [Presentation] 骨軟部肉腫における癌幹細胞を標的とする免疫療法「パネルディスカッションI幹細胞研究の骨・軟部腫瘍学への応用」 (2011)
  • Author(s): 塚原智英, 和田卓郎, 他
  • Organizer: 第44回日本整形外科学会骨軟部腫瘍学術集会
  • Place of Presentation: 京都市
  • Year and Date: 2011-06-30
• [Presentation] 骨肉腫のペプチドワクチン療法(シンポ) (2011)
  • Author(s): 和田卓郎, 他
  • Organizer: 第84回日本整形外科学会学術集会
  • Place of Presentation: 横浜市
  • Year and Date: 2011-05-13
• [Presentation] Generation of TCR-like antibody against HLA/peptide complex of an osteosarcoma antigen PBF (2011)
  • Author(s): 塚原智英, 鳥越俊彦, 佐藤昇志, 和田卓郎
  • Organizer: 第70回日本癌学会学術総会
  • Place of Presentation: 名古屋
• [Presentation] 骨軟部肉腫における癌幹細胞を標的とする免疫療法「パネルディスカッションI幹細胞研究の骨・軟部腫瘍学への応用」 (2011)
  • Author(s): 塚原智英, 佐藤昇志, 嘉野真允, 江森誠, 山下敏彦, 和田卓郎
  • Organizer: 第44回日本整形外科学会骨軟部腫瘍学術集会
  • Place of Presentation: 京都
• [Presentation] Scythe/BAT3 regulates apoptotic cell death induced (2010)
  • Author(s): Tomohide Tsukahara, Shigeharu Kimura, Shingo Ichimiya, Satoshi Kawaguchi, Masanobu Kano, Takuro Wada, Toshihiko Torigoe, Toshihiko Yamashita, Noriyuki Sato
  • Organizer: The osteosarcoma antigen PBF in human osteosarcoma 16th Annual Connective Tissue Oncology Society Meeting
  • Place of Presentation: Paris
  • Year and Date: 2010-11-13
• [Presentation] 小児骨腫瘍の画像診断(日整会教育研修講演) (2010)
  • Author(s): 和田卓郎
  • Organizer: 日本小児整形外科学会第17回研修会
  • Place of Presentation: 大正製薬株式会社(東京都)
  • Year and Date: 2010-08-22
• [Presentation] 骨肉腫・滑膜肉腫のペプチドワクチン療法 (2010)
  • Author(s): 和田卓郎
  • Organizer: 第78回骨軟部肉腫瘍治療研究会
  • Place of Presentation: 京王プラザホテル(東京都)
  • Year and Date: 2010-05-28
• [Presentation] Clinical and immunologic responses of synovial sarcoma patients treated with SYT-SSX fusion gene-derived peptide vaccine(English workshop) (2010)
  • Author(s): Kawaguchi S, Wada T, et al
  • Organizer: 第69回日本癌学会学術総会
  • Place of Presentation: リーガロイヤルホテル大阪,大阪国際会議場(大阪)
• [Presentation] 骨軟部腫瘍における癌幹細胞の同定とその免疫学的性質の解析 (2010)
  • Author(s): 嘉野真允, 和田卓郎, 他
  • Organizer: 第43回日本整形外科学会骨軟部腫瘍学術集会
  • Place of Presentation: 京王プラザホテル(東京都)
• [Presentation] Development of peptide vaccination therapy targeting apoptisis regulator protain PBF for patients with osteosarcoma. (2010)
  • Author(s): Tsukahara T, Wada T, et al.
  • Organizer: International Congress of Immunology(第14回)
  • Place of Presentation: 神戸ポートピアホテル、神戸国際展示場(兵庫県)
• [Presentation] Clinical and immunologic responses of synovial sarcoma patients treated with SYT-SSX fusion gene-derived peptide vaccine(English workshop). (2010)
  • Author(s): Kawaguchi S, Wada T, et al.
  • Organizer: 第69回日本癌学会学術総会
  • Place of Presentation: リーガロイヤルホテル大阪、大阪国際会議場(大阪府)
• [Presentation] Scythe/BAT3 regulates apoptotic cell death induced by the osteosarcoma antigen PBF in human osteosarcoma. (2010)
  • Author(s): Tsukahara T, Wada T, et al.
  • Organizer: Connective Tissue Oncology Society(第16回)
  • Place of Presentation: ル メリディアン エトワールホテル(フランスパリ)
• [Presentation] Clinical and immunologic responses of synovial sarcoma patients treated with SYT-SSX fusion gene-derived peptide vaccines. (2010)
  • Author(s): Kawaguchi S, Wada T, et al.
  • Organizer: Connective Tissue Oncology Society(第16回)
  • Place of Presentation: ル メリディアン エトワールホテル(フランスパリ)
• [Presentation] 当科における75歳以上の原発性悪性軟部腫瘍の治療成績 (2010)
  • Author(s): 佐々木幹人, 和田卓郎, 他
  • Organizer: 第43回日本整形外科学会骨軟部腫瘍学術集会
  • Place of Presentation: 京王プラザホテル(東京都)
• [Presentation] 仙骨骨巨細胞腫に対する動脈塞栓術 (2010)
  • Author(s): 加谷光規, 和田卓郎, 他
  • Organizer: 第43回日本整形外科学会骨軟部腫瘍学術集会
  • Place of Presentation: 京王プラザホテル(東京都)
• [Presentation] Myxofibrosarcima局所再発の危険因子 (2010)
  • Author(s): 加谷光規, 和田卓郎, 他
  • Organizer: 第43回日本整形外科学会骨軟部腫瘍学術集会
  • Place of Presentation: 京王プラザホテル(東京都)
• [Presentation] 神経鞘腫の鑑別を要した上肢悪性軟部腫瘍例の臨床像と画像所見の検討 (2010)
  • Author(s): 織田崇, 和田卓郎, 他
  • Organizer: 第119回北海道整形災害外科学会
  • Place of Presentation: 北海道大学学術交流会館(札幌市)
• [Presentation] 骨軟部腫瘍における癌幹細胞の同定とその免疫学的性質の解析 (2010)
  • Author(s): 嘉野真允, 和田卓郎, 他
  • Organizer: 第69回日本癌学会学術総会
  • Place of Presentation: リーガロイヤルホテル大阪、大阪国際会議場(大阪府)
• [Presentation] 骨軟部腫瘍における癌幹細胞の同定とその免疫学的性質の解析 (2010)
  • Author(s): 嘉野真允, 和田卓郎, 他
  • Organizer: 第99回日本病理学会総会
  • Place of Presentation: 京王プラザホテル(東京都)
• [Presentation] 骨軟部肉腫のペプチドワクチン療法 (2009)
  • Author(s): 和田卓郎
  • Organizer: 第3回金沢骨軟部腫瘍セミナー
  • Place of Presentation: 金沢市
  • Year and Date: 2009-12-12
• [Presentation] 骨・軟部肉腫のペプチドワクチン療法 (2009)
  • Author(s): 和田卓郎, 他
  • Organizer: 第42回日本整形外科学会骨軟部腫瘍学術集会
  • Place of Presentation: 横浜市
  • Year and Date: 2009-07-16
• [Presentation] HLA-A2拘束性骨肉腫抗原PBFペプチドに対する基礎的研究と第1相臨床試験 (2009)
  • Author(s): 塚原智英, 川口哲, 和田卓郎, 名越智, 加谷光規, 嘉野真允, 山下敏彦, 鳥越俊彦, 佐藤昇志
  • Organizer: 第24回日本整形外科学会基礎学術集会
  • Place of Presentation: 横浜
• [Presentation] Scythe/BAT3はPBFに誘導されるAIF依存的な骨肉腫の細胞死を制御する (2009)
  • Author(s): 塚原智英, 木村重治, 川口哲, 嘉野真允, 和田卓郎, 山下敏彦, 一宮慎吾, 鳥越俊彦, 佐藤昇志
  • Organizer: 第42回日本整形外科学会骨軟部腫瘍学術集会
  • Place of Presentation: 横浜
• [Presentation] Characterization and clinical vaccination study of HLA-A* 0201-restricted epitope of the osteosarcoma antigen PBF (2009)
  • Author(s): 塚原智英, 川口哲, 嘉野真允, 和田卓郎, 山下敏彦, 鳥越俊彦, 高橋あかり, 佐藤昇志
  • Organizer: 第13回日本がん免疫学会総会
  • Place of Presentation: 北九州
• [Presentation] HLA-A2拘束性骨肉腫抗原PBFペプチドに関する基礎的研究と第1相臨床試験 (2009)
  • Author(s): 塚原智英, 川口哲, 和田卓郎, 他
  • Organizer: 第24回日本整形外科学会基礎学術集会
  • Place of Presentation: 横浜市
• [Presentation] Scythe/BAT3はPBFに誘導されるAIF依存的な骨肉腫の細胞死を制御する (2009)
  • Author(s): 塚原智英, 和田卓郎, 他
  • Organizer: 第99回日本病理学会総会
  • Place of Presentation: 京都
• [Presentation] Characterization and clinical vaccination study of HLA-A*0201-restricted epitope of the osteosarcoma antigen PBF (2009)
  • Author(s): 塚原智英, 和田卓郎, 他
  • Organizer: 第13回日本がん免疫学会総会
  • Place of Presentation: 北九州市
• [Presentation] Development of HLA-A2 and HLA-A24-restricted peptide vaccines from a novel osteosarcoma antigen, papillomavirus binding factor (2009)
  • Author(s): 川口哲, 塚原智英, 和田卓郎, et al.
  • Organizer: Connective Tissue Oncology Society(CTOS)
  • Place of Presentation: Miami, USA
• [Presentation] Side population cells have the characteristics of cancer stem-like cells/cancer-initiating cells in bone sarcomas (2009)
  • Author(s): Murase M, Kano M, Tsukahara T, Wada T, et al.
  • Organizer: Connective Tissue Oncology Society(CTOS)
  • Place of Presentation: Miami, USA
• [Presentation] 血清VEGF濃度は骨肉腫症例の予後予測因子である:前向き検討 (2009)
  • Author(s): 加谷光規, 和田卓郎, 他
  • Organizer: 第24回日本整形外科学会基礎学術集会
  • Place of Presentation: 横浜市
• [Presentation] 骨・軟部肉腫における癌幹細胞の同定とその免疫学的性質の解析 (2009)
  • Author(s): 嘉野真允, 和田卓郎, 他
  • Organizer: 第42回日本整形外科学会骨・軟部腫瘍学術集会
  • Place of Presentation: 東京都
• [Presentation] Scythe/BAT3は骨肉腫抗原PBFに誘導される apoptosis-inducing factor 依存的な骨肉腫の細胞死を制御する (2009)
  • Author(s): 塚原智英, 和田卓郎, 他
  • Organizer: 第42回日本整形外科学会骨・軟部腫瘍学術集会
  • Place of Presentation: 東京都
• [Presentation] Immunological profiles of cancer stem-like cells in human bone and soft tissue sarcomas (2009)
  • Author(s): 嘉野真允, 和田卓郎, 他
  • Organizer: 第42回日本整形外科学会骨・軟部腫瘍学術集会
  • Place of Presentation: 東京都
• [Presentation] 軟部腫瘍の治療(教育研修講演) (2008)
  • Author(s): 和田卓郎
  • Organizer: 第20回日本整形外科学会骨・軟部腫瘍特別研修会
  • Place of Presentation: 京都市
  • Year and Date: 2008-10-24
• [Presentation] 骨軟部腫瘍抗原を分子標的とした癌ワクチン療法(特別講演) (2008)
  • Author(s): 和田卓郎
  • Organizer: 第10回Macnab Memorial Lecture
  • Place of Presentation: 郡山市
  • Year and Date: 2008-09-20
• [Presentation] 上肢の良性・悪性腫瘍(教育研修講演) (2008)
  • Author(s): 和田卓郎
  • Organizer: 日本手の外科学会第14回秋期教育研修会
  • Place of Presentation: 名古屋市
  • Year and Date: 2008-09-07
• [Presentation] 新規骨軟部肉腫抗原を標的としたペプチドワクチン療法(特別講演) (2008)
  • Author(s): 和田卓郎
  • Organizer: 北海道患免疫制御研究会
  • Place of Presentation: 札幌市
  • Year and Date: 2008-06-07
• [Presentation] 滑膜肉腫に対するペプチドワクチン療法の進捗状況. (2008)
  • Author(s): 和田卓郎
  • Organizer: 第74回骨軟部肉腫治療研究会
  • Place of Presentation: 札幌市
  • Year and Date: 2008-05-23
• [Presentation] The third vaccination trial of SYT-SSX junction peptide in patients with disseminated synovial sarcoma (2008)
  • Author(s): Wada T, Kawaguchi S, Tsukahara T, Ida K, Murase M, Nagoya S, Kaya M, Torigoe T, Sato N, Yamashita T
  • Organizer: 14th Annual CTOS Meeting
  • Place of Presentation: London
• [Presentation] Scythe/BAT3 regulates apoptotic cell death induced by papillomavirus binding factor in human osteosarcoma (2008)
  • Author(s): 塚原智英, 木村重治, 川口哲, 和田卓郎, 山下敏彦, 一宮慎吾, 鳥越俊彦, 佐藤昇志
  • Organizer: 第67回日本癌学会総会
  • Place of Presentation: 名古屋
• [Presentation] 新規骨肉腫抗原PBF由来ペプチドに対するHLA-A2陽性骨肉腫患者の免疫応答 (2008)
  • Author(s): 塚原智英, 川口哲, 村瀬正樹, 和田卓郎, 名越智, 加谷光規, 山下敏彦, 鳥越俊彦, 佐藤昇志
  • Organizer: 第41回日本整形外科学会骨軟部腫瘍学術集会
  • Place of Presentation: 浜松市
• [Presentation] The third vaccination trial of SYT-SSX junction peptide in patients with disseminated synovial sarcoma (2008)
  • Author(s): Wada T, et al
  • Organizer: 14th Annual CTOS Meeting
  • Place of Presentation: ロンドン
• [Presentation] The third vaccination trial of SYT-SSX junction peptide in patients with disseminated synovial sarcoma. (2008)
  • Author(s): Wada T
  • Organizer: 14th Annual CTOS Meeting
  • Place of Presentation: London
• [Presentation] SYT-SSX遺伝子由来抗原ペプチド開発研究に基づく滑膜肉腫に対する免疫療法. (2008)
  • Author(s): 井田和功
  • Organizer: 第41回日本整形外科学会骨・軟部腫瘍学術集会
  • Place of Presentation: 浜松市
• [Presentation] 新規骨肉腫腫瘍抗原PBF由来ペプチドに対するHLA-A2陽性骨肉腫患者の免疫応答. (2008)
  • Author(s): 塚原智英
  • Organizer: 第41回日本整形外科学会骨・軟部腫瘍学術集会
  • Place of Presentation: 浜松市
• [Presentation] 骨・軟部肉腫における癌幹細胞の同定 (2008)
  • Author(s): 村瀬正樹
  • Organizer: 第41回日本整形外科学会骨・軟部腫瘍学術集会
  • Place of Presentation: 浜松市
• [Presentation] 新規骨肉腫抗原PBF由来ペプチドに対するHLA-A2陽性骨肉腫患者の免疫応答. (2008)
  • Author(s): 塚原智英
  • Organizer: 第23回日本整形外科学会基礎学術集会
  • Place of Presentation: 京都市
• [Presentation] 骨・軟部腫瘍における免疫学的分子標的アプローチ. (2008)
  • Author(s): 川口哲
  • Organizer: 第23回日本整形外科学会基礎学術集会
  • Place of Presentation: 京都市
• [Book] 骨軟骨腫,内軟骨腫,単純性骨嚢腫-今日の治療指針2011年版. (2011)
  • Author(s): 和田卓郎
  • Total Pages: 984
  • Publisher: 医学書院
• [Book] 軟部腫瘍の診察の基本.整形外科臨床パサージュ6,軟部腫瘍プラティカルガイド (2011)
  • Author(s): 加谷光規, 和田卓郎
  • Publisher: 中山書店
• [Book] 今日の治療指針2011年版.骨軟骨腫,内軟骨腫,単純性骨嚢腫 (2011)
  • Author(s): 和田卓郎
  • Total Pages: 984
  • Publisher: 医学書院
• [Book] 傍骨性骨肉腫-アトラス骨・関節画像診断骨軟部腫瘍 (2010)
  • Author(s): 加谷光規, 和田卓郎
  • Publisher: 中外医学社
• [Book] アトラス骨・関節画像診断骨軟部腫瘍 (2010)
  • Author(s): 加谷光規, 和田卓郎
  • Total Pages: 166
  • Publisher: 中外医学社
• [Book] 今日の治療指針2011年版 (2010)
  • Author(s): 和田卓郎
  • Total Pages: 984
  • Publisher: 医学書院
• [Book] アトラス骨・関節画像診断 骨軟部腫瘍 (2010)
  • Author(s): 加谷光規, 和田卓郎
  • Total Pages: 166
  • Publisher: 中外医学社
• [Book] 今日の治療指針 2011年版 (2010)
  • Author(s): 和田卓郎
  • Total Pages: 984
  • Publisher: 医学書院
• [Remarks]
  • URL: http://web.sapmed.ac.jp/orsurg/index.html
• [Remarks]
  • URL: http://web.sapmed.ac.jp/orsurg/basic_invest/index.html
• [Remarks]
  • URL: http://web.sapmed.ac.jp/orsurg/basic_invest/index.html
• [Remarks]
  • URL: http://web.sapmed.ac.jp/orsurg/basic_invest/index.html
• [Remarks]
  • URL: http://web.sapmed.ac.jp/orsurg/index.html
• [Patent(Industrial Property Rights)] Tumor antigen peptide and use thereof (2011)
  • Inventor(s): 佐藤昇志,塚原智英,川口哲,和田卓郎
  • Industrial Property Rights Holder: 佐藤昇志,塚原智英,川口哲,和田卓郎
  • Acquisition Date: 2011-06-29
  • Overseas
• [Patent(Industrial Property Rights)] 腫瘍抗原ペプチド及びその利用 (2008)
  • Inventor(s): 佐藤昇志,塚原智英,川口哲,和田卓郎
  • Industrial Property Rights Holder: 佐藤昇志,塚原智英,川口哲,和田卓郎
  • Acquisition Date: 2008-10-20
• [Patent(Industrial Property Rights)] SYT-SSX改変ペプチド (2008)
  • Inventor(s): 佐藤昇志, 和田卓郎, 他
  • Industrial Property Rights Holder: 佐藤昇志
  • Acquisition Date: 2008-12-12