| Budget Amount *help |
¥18,330,000 (Direct Cost: ¥14,100,000、Indirect Cost: ¥4,230,000)
Fiscal Year 2011: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2010: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2009: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2008: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
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| Research Abstract |
Disruption of Apo E gene with high fat diet resulted in trabecular bone loss and reduced bone formation at the secondary spongiosa of the tibia in mice. In these disrupted mice, apoptosis was induced in osteoblasts through enhanced expression of p53 mRNA and osteoblastic differentiation and proliferation were suppressed. Bone formation was decreased. Disruption of aldehyde-dehydrogenase 2 gene with alcohol intake resulted in trabecular bone loss and reduced bone formation in mice. Cell cycle arrest was induced through enhanced expression of p21 mRNA and osteoblastic mineralization was disturbed. Bone formation was decreased. Thus, we demonstrated the mechanism underlying trabecular bone loss induced by alcohol intake or high fat diet through cell cycle arrest or apoptosis of osteoblasts.
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