Study of TGFβ signaling during angiogenesis in bone metastasis sites by using in vivo optical imaging
| Project/Area Number |
20390407
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Orthopaedic surgery
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| Research Institution | Ehime University (2010)
Japanese Foundation For Cancer Research (2008-2009) |
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Principal Investigator |
IMAMURA Takeshi Ehime University, 大学院・医学系研究科, 教授 (70264421)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥19,240,000 (Direct Cost: ¥14,800,000、Indirect Cost: ¥4,440,000)
Fiscal Year 2010: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2009: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
Fiscal Year 2008: ¥7,150,000 (Direct Cost: ¥5,500,000、Indirect Cost: ¥1,650,000)
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| Keywords | バイオテクノロジー / シグナル伝達 / 酵素 / 生体分子 / 細胞・組織 / シグナル云達 |
|---|
| Research Abstract |
In order to clarify the roles of TGF-β/BMP signaling during angiogenesis in bone metastasis sites of breast cancer, we developed advanced in vivo optical imaging systems by which we can visualize tumor angiogenesis and TGF-β/BMP at the same time. In addition, we studied the effects of angiogenesis inhibitors and TGF-β/BMP signaling blockers during bone metastasis of breast cancer in vivo.
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Report
(4 results)
Research Products
(42 results)
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[Journal Article] Estrogen inhibits transforming growth factor b signaling by promoting Smad2/3 degradation2010
Author(s)
Ito I, Hanyu A, Wayama M, Goto N, Katsuno Y, Kawasaki S, Nakajima Y, Kajiro M, Komatsu Y, Fujimura A, Hirota R, Murayama A, Kimura K, Imamura T, Yanagisawa J.
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Journal Title
J Biol Chem 285
Pages: 14747-1455
Related Report
Peer Reviewed
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[Journal Article] Runx1 and Runx2 cooperate during sternal morphogenesis2010
Author(s)
Kimura A, Inose H, Yano F, Fujita K, Ikeda T, Sato S, Iwasaki M, Jinno T, Ae K, Fukumoto S, Takeuchi Y, Itoh H, Imamura T, Kawaguchi H, Chung UI, Martin JF, Iseki S, Shinomiya K, Takeda S.
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Journal Title
Development 137
Pages: 1159-1167
Related Report
Peer Reviewed
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[Journal Article] Functional in vivo optical imaging of tumor angiogenesis, growth, and metastasis prevented by administration of anti-human VEGF antibody in xenograft model of human fibrosarcoma HT1080 cells2009
Author(s)
Hanyu A, Kojima K, Hatake K, Nomura K, Murayama H, Ishikawa Y, Miyata S, Ushijima M, Matsuura M, Ogata E, Miyazawa K, Imamura T
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Journal Title
Cancer Sci 100
Pages: 2085-2092
NAID
Related Report
Peer Reviewed
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