Analysis of inhaled anesthetics on the analgesic effect and immobilization in the spinal cord

• Project/Area Number: 20390414
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Anesthesiology/Resuscitation studies
• Research Institution: Niigata University
• Principal Investigator: KOHNO Tatsuro Niigata University, 医歯学系, 准教授 (00313536)
• Co-Investigator(Kenkyū-buntansha): IKOMA Miho 新潟大学, 医歯学総合病院, 助教 (30432082)
• Co-Investigator(Renkei-kenkyūsha): TERUMASA Nakatsuka 佐賀大学, 医学部, 准教授 (30380752)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥15,080,000 (Direct Cost: ¥11,600,000、Indirect Cost: ¥3,480,000); Fiscal Year 2010: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000); Fiscal Year 2009: ¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000); Fiscal Year 2008: ¥6,110,000 (Direct Cost: ¥4,700,000、Indirect Cost: ¥1,410,000)
• Keywords: 脊髄 / 麻酔薬 / 鎮痛 / 不動化

Research Abstract

General anesthetics have the actions of hypnosis, amnesia, analgesia and immobility. To elucidate the effects of nitrous oxide and xenon in spinal dorsal horn neurons, we conducted the electrophysiological experiments. We revealed that nitrous oxide had no effects on the inhibitory synaptic transmission in dorsal horn neurons. In addition, xenon inhibited excitatory but not inhibitory transmission in dorsal horn neurons, leading to the antinociceptive effect.

Research Products

• [Journal Article] キセノンの脊髄後角における興奮性・抑制性シナプス伝達に対する作用 (2011)
  • Author(s): ゲオルギエフ ステファン、古江秀昌、河野達郎
  • Journal Title: 脊髄機能診断学 32巻 Pages: 214-216
  • Peer Reviewed
• [Journal Article] 脊髄における全身麻酔薬の作用機序 (2011)
  • Author(s): 山本知裕、本田博之、河野達郎
  • Journal Title: 麻酔 60 Pages: 582-589
  • Peer Reviewed
• [Journal Article] Zaltoprofen inhibits bradykinin-mediated enhancement of glutamate receptor activity in substantia getatinosa neurons (2011)
  • Author(s): Kohno T
  • Journal Title: Anesth Analg
  • Peer Reviewed
• [Journal Article] Nitrous oxide and the inhibitory synaptic transmission in rat dorsal horn neurons (2010)
  • Author(s): Stefan K Georgiev、Hiroshi Baba、Tatsuro Kohno
  • Journal Title: European Journal of Pain 14 Pages: 17-22
  • Peer Reviewed
• [Journal Article] Xenon inhibits excitatory but not inhibitory transmission in rat spinal cord dorsal horn neurons (2010)
  • Author(s): Stefan K Georgiev、Hidemasa Furue、Hiroshi Baba、Tatsuro Kohno
  • Journal Title: Molecular Pain 6 Pages: 25-25
  • Peer Reviewed
• [Journal Article] 亜酸化窒素の脊髄後角II層における抑制性シナプス伝達に対する作用 (2010)
  • Author(s): ゲオルギエフ・ステファン、馬場洋、河野達郎
  • Journal Title: 脊髄機能診断学 33巻 Pages: 12-18
  • Peer Reviewed
• [Journal Article] Bupivacaine inhibits glutamatergic transmission in spinal dorsal hornneurons (2010)
  • Author(s): Furutani K, 他4名
  • Journal Title: Anesthesiology Volume: 1121 Pages: 138-143
  • Peer Reviewed
• [Journal Article] Nitrous oxide and the inhibitory synaptic transmission in ratdorsal horn neurons (2010)
  • Author(s): Georgiev SK, 他4名
  • Journal Title: European Journal of Pain Volume: 141 Pages: 17-22
  • Peer Reviewed
• [Journal Article] Bupivacaine inhibits glutamatergic transmission in spinal dorsal horn neurons (2010)
  • Author(s): Furutani K, 他4名
  • Journal Title: Anesthesiology Volume: 1121 Pages: 138-143
  • Peer Reviewed
• [Journal Article] Nitrous oxide and the inhibitory synaptic transmission in rat dorsal horn neurons (2010)
  • Author(s): Georgiev SK, 他4名
  • Journal Title: European Journal of Pain Volume: 141 Pages: 17-22
  • Peer Reviewed
• [Journal Article] Reduced immobilizing properties of isoflurane and nitrous oxide in mutant mice lacking the N-methyl-D-aspartate receptor GluR(epsilon)1 subunit are caused by the secondary effects of gene knockout (2010)
  • Author(s): Petrenko AB, 他4名
  • Journal Title: Anesth Analg Volume: 1102 Pages: 461-465
  • Peer Reviewed
• [Journal Article] Nitrous oxide and the inhibitory synaptic transmissionin rat dorsa1 horn neurons (2009)
  • Author(s): Georgiev SK, 他4名
  • Journal Title: European Journal of Pain (印刷中)
  • Peer Reviewed
• [Journal Article] Taurine activates glycine and gamma-aminobutyric acid receptors in rat substanti a gelatinosa neurons (2008)
  • Author(s): Wu J, 他6名
  • Journal Title: Neuroreport 19 Pages: 333-337
  • Peer Reviewed
• [Journal Article] Action of dexmedetomidine on the substantia gelatinosaneurons of the rat spinal cord (2008)
  • Author(s): Ishii H, 他4名
  • Journal Title: European Journal of Neuroscience 27 Pages: 3182-3190
  • Peer Reviewed
• [Presentation] 脊髄運動ニューロンのシナプス伝達に対するキセノンの作用 (2011)
  • Author(s): 山本知裕、本田博之、河野達郎
  • Organizer: 第58回日本麻酔科学会学術集会
  • Place of Presentation: 兵庫県
  • Year and Date: 2011-05-20
• [Presentation] Xenon inhibits excitatory but not inhibitory transmission in rat spinal cord dorsal horn neurons (2010)
  • Author(s): Stefan K Georgiev、Tatsuro Kohno、Tatsuro Kohno
  • Organizer: 40^<th> Annual meeting of neuroscience
  • Place of Presentation: San Diego(CA,USA)
  • Year and Date: 2010-11-15
• [Presentation] キセノンの脊髄後角における興奮性・抑制性シナプス伝達に対する作用 (2010)
  • Author(s): 河野達郎、ゲオルギエフ ステファン
  • Organizer: 第57回日本麻酔科学会学術集会
  • Place of Presentation: 福岡県
  • Year and Date: 2010-06-04
• [Presentation] キセノンの脊髄後角における興奮性・抑制性シナプス伝達に対する作用 (2010)
  • Author(s): 河野達郎, 他1名
  • Organizer: 日本麻酔科学会第57回学術集会
  • Place of Presentation: 福岡
  • Year and Date: 2010-06-04
• [Presentation] キセノンの脊髄後角における興奮性・抑制性シナプス伝達に対する作用 (2010)
  • Author(s): ゲオルギエフ ステファン、古江秀昌、河野達郎
  • Organizer: 第32回脊髄機能診断研究会
  • Place of Presentation: 東京都
  • Year and Date: 2010-02-06
• [Presentation] キセノンの脊髄後角における興奮性・抑制性シナプス伝達に対する作用 (2010)
  • Author(s): ゲオルギエフステファン
  • Organizer: 第32回脊髄機能診断研究会
  • Place of Presentation: 東京
  • Year and Date: 2010-02-06
• [Presentation] 亜酸化窒素の脊髄第II層における抑制性シナプス伝達に対する作用 (2009)
  • Author(s): ゲオルギエフ ステファン、河野達郎
  • Organizer: 第31回脊髄機能診断研究会
  • Place of Presentation: 東京都
  • Year and Date: 2009-02-07
• [Presentation] 亜酸化窒素の脊髄第II層における抑制性シナプス伝達に対する作用 (2009)
  • Author(s): ゲオルギェフステファン
  • Organizer: 第31回脊髄機能診断研究会
  • Place of Presentation: 東京
  • Year and Date: 2009-02-07