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Translational research of animal study and clinical trial for the mechanisms of weather-dependent pain aggravation.

Research Project

Project/Area Number 20390415
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Anesthesiology/Resuscitation studies
Research InstitutionNagoya University

Principal Investigator

SATO Jun  Nagoya University, 環境医学研究所, 准教授 (00235350)

Co-Investigator(Kenkyū-buntansha) USHIDA Takahiro  愛知医科大学, 医学部, 教授 (60304680)
Co-Investigator(Renkei-kenkyūsha) SAKURAI Hiroki  浜松大学, 保健医療学部, 講師 (60454419)
Project Period (FY) 2008 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥19,110,000 (Direct Cost: ¥14,700,000、Indirect Cost: ¥4,410,000)
Fiscal Year 2010: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2009: ¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
Fiscal Year 2008: ¥10,270,000 (Direct Cost: ¥7,900,000、Indirect Cost: ¥2,370,000)
Keywords慢性疼痛 / 気象 / うつ病 / 自律神経 / 内耳前庭 / 慢性痛 / 大気圧 / うつ
Research Abstract

The authors have clarified underlying mechanisms of weather-sensitive diseases, such as chronic pain and depression in the basic animal research. In the present research project, we have further progressed the animal study and had clinical study using chronic pain patients with their pain to be sensitive to weather change. This translational study succeeded to product human model of weather-sensitive pain and provided a scientific link between laboratory research and human trials, and the beginning of discovery of therapeutic strategies for this syndrome.

Report

(4 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (53 results)

All 2011 2010 2009 2008 Other

All Journal Article (17 results) (of which Peer Reviewed: 11 results) Presentation (30 results) Book (2 results) Remarks (2 results) Patent(Industrial Property Rights) (2 results)

  • [Journal Article] 天気変化と痛み2011

    • Author(s)
      佐藤純
    • Journal Title

      Anesthesia Network

      Volume: 15(1) Pages: 32-34

    • Related Report
      2010 Annual Research Report
  • [Journal Article] 天候変化と気分障害2011

    • Author(s)
      佐藤純
    • Journal Title

      日本生気象学会雑誌

      Volume: 48(1)(印刷中,未定)

    • NAID

      10028193999

    • Related Report
      2010 Annual Research Report
  • [Journal Article] Lowering barometric pressure aggravates depression-like behavior in rats2010

    • Author(s)
      MIZOGUCHI Hiroyuki, FUKAYA Kanoko, MORI Rarami, ITOH Mariko, FUNAKUBO Megumi, SATO Jun
    • Journal Title

      Behavioural Brain Research Vol.218

      Pages: 190-193

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Increases in neuronal activity in rat spinal trigeminal nucleus following changes in barometric pressure-relevance for weather-associated headache2010

    • Author(s)
      MESSLINGER Karl, FUNAKUBO Megumi, SATO Jun, MIZUMURA Kazue
    • Journal Title

      Headache Vol.50, No.9

      Pages: 1449-1463

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] The inner ear is involved in the aggravation of nociceptive behavior induced by lowering barometric pressure of nerve injured rats2010

    • Author(s)
      FUNAKUBO Megumi, SATO Jun HONDA Takashi, MIZUMURA Kazue
    • Journal Title

      European Journal of Pain Vol.14, No.1

      Pages: 32-39

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Behavior of children emerging from general anesthesia correlates with their heart rate variability2010

    • Author(s)
      Arai P Young-Chang
    • Journal Title

      Journal of Anesthesia

      Volume: 24(2) Pages: 317-318

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Development of comprehensive diagnostic criteria for complex regional pain syndrome in the Japanese population2010

    • Author(s)
      Sumitani Masahiko
    • Journal Title

      Pain

      Volume: 150(2) Pages: 243-249

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Increases in neuronal activity in rat spinal trigeminal nucleus following changes in barometric pressure-relevance for weather-associated2010

    • Author(s)
      Messlinger Karl
    • Journal Title

      Headaches

      Volume: 50(9) Pages: 1449-1443

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Lowering barometric pressure aggravates depression-like behavior in rats2010

    • Author(s)
      Mizoguchi Hiroyuki
    • Journal Title

      Behavioural Brain Research

      Volume: 218(1) Pages: 190-193

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The inner ear is involved in the aggravation of nociceptive behavior induced by lowering barometric pressure of nerve injured rats2010

    • Author(s)
      Megumi Funakubo
    • Journal Title

      European Journal of Pain 14(1)

      Pages: 32-39

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 神経障害性疼痛に関する基礎研究 交感神経が関与する痛み2009

    • Author(s)
      佐藤純
    • Journal Title

      ペインクリニック 30

      Pages: 65-72

    • Related Report
      2009 Annual Research Report
  • [Journal Article] 自律神経2009

    • Author(s)
      佐藤純
    • Journal Title

      複合性局所疼痛症候群

      Pages: 37-40

    • Related Report
      2009 Annual Research Report
  • [Journal Article] 基礎 : 痛みと自律系2009

    • Author(s)
      佐藤純
    • Journal Title

      理学療法 26

      Pages: 326-333

    • Related Report
      2008 Annual Research Report
  • [Journal Article] Changes in cardiovascular parameters and plasma norepinephrine level in rats after chronic constriction injury on the sciatic nerve2008

    • Author(s)
      Yu Jin
    • Journal Title

      PAIN 135

      Pages: 221-231

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 慢性痛と交感神経系2008

    • Author(s)
      佐藤純
    • Journal Title

      理学療法MOOK3疼痛の理学療法 第2版

      Pages: 41-49

    • Related Report
      2008 Annual Research Report
  • [Journal Article] The rate and magnitude of atmospheric pressure change that aggravate pain-related behavior of nerve injured rats

    • Author(s)
      Funakubo Megumi
    • Journal Title

      International Journal of Biometeorology

      Volume: (印刷中,未定)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Comparative effects of acupressure at local and distal acupuncture points on pain conditions and autonomic function in females with chronic neck pain

    • Author(s)
      Matsubara Takako
    • Journal Title

      Evidence-Based Complementary and Alternative Medieine

      Volume: (印刷中,未定)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] Transplantation of bone marrow-derived mononuclear cells ameliorates hyperalgesia observed in the early stage of diabetes in rats2011

    • Author(s)
      Sato Jun
    • Organizer
      第88回日本生理学会大会
    • Place of Presentation
      The Journal of Physiological Sciences
    • Year and Date
      2011-03-28
    • Related Report
      2010 Annual Research Report
  • [Presentation] The effect of treadmill exercise on the long-lasting mechanical hypera lgesia induced by cast immobilization in rats2011

    • Author(s)
      Morimoto Atsuko
    • Organizer
      第88回日本生理学会大会
    • Place of Presentation
      The Journal of Physiological Sciences
    • Year and Date
      2011-03-28
    • Related Report
      2010 Annual Research Report
  • [Presentation] 意志決定の行動学的解析:放射状迷路を用いた小動物用ギャンブルテスト2010

    • Author(s)
      溝口博之
    • Organizer
      第118回日本薬理学会近畿部会
    • Place of Presentation
      千里ライフセンタービル(大阪府)
    • Year and Date
      2010-11-19
    • Related Report
      2010 Annual Research Report
  • [Presentation] 寒冷ストレスによる気分障害および慢性痛モデルラットの血中ノルアドレナリン量の変化2010

    • Author(s)
      佐藤純
    • Organizer
      第49回日本生気象学会
    • Place of Presentation
      東京
    • Year and Date
      2010-11-05
    • Related Report
      2010 Final Research Report
  • [Presentation] 痛みと自律神経,痛みと環境・気象2010

    • Author(s)
      佐藤純
    • Organizer
      痛みを基礎と臨床から考える会
    • Place of Presentation
      阪急グランドビル(大阪府)
    • Year and Date
      2010-09-12
    • Related Report
      2010 Annual Research Report
  • [Presentation] Impairments of subjective sensitivity and thermoregulatory function in chronic pain patients exposed to ambient temperature change2010

    • Author(s)
      Sakurai Hiroki
    • Organizer
      13th World Congress on Pain
    • Place of Presentation
      Palais des Congres de Mont real (Canada)
    • Year and Date
      2010-09-01
    • Related Report
      2010 Annual Research Report
  • [Presentation] Chronic mechanical hyperalgesia and local extravasation induced by two-week cast immobilization in rats2010

    • Author(s)
      Ohmichi Yusuke
    • Organizer
      13th World Congress on Pain
    • Place of Presentation
      Palais des Congres de Montreal (Canada)
    • Year and Date
      2010-09-01
    • Related Report
      2010 Annual Research Report
  • [Presentation] ストレス誘発性抑うつモデルマウスにみられた神経障害性疹痛の増強2010

    • Author(s)
      大宮康次郎
    • Organizer
      第32回日本終痛学会
    • Place of Presentation
      京都国際会館(京都府)
    • Year and Date
      2010-07-03
    • Related Report
      2010 Annual Research Report
  • [Presentation] 寒さを感じなくなった慢性痛患者に対する環境温暴露試験2010

    • Author(s)
      櫻井博紀
    • Organizer
      第32回日本痺痛学会
    • Place of Presentation
      京都国際会館(京都府)
    • Year and Date
      2010-07-03
    • Related Report
      2010 Annual Research Report
  • [Presentation] 気象病における自律神経系の関与2010

    • Author(s)
      佐藤純
    • Organizer
      第39回日本脊椎脊髄病学会
    • Place of Presentation
      三翠園(高知県)
    • Year and Date
      2010-04-23
    • Related Report
      2010 Annual Research Report
  • [Presentation] 気圧低下曝露がラットの抑うつ状態に与える影響2010

    • Author(s)
      佐藤純
    • Organizer
      第13回バイオクリマ研究成果発表会
    • Place of Presentation
      東京
    • Year and Date
      2010-03-13
    • Related Report
      2009 Annual Research Report
  • [Presentation] 慢性疼痛と自律神経機能2010

    • Author(s)
      佐藤純
    • Organizer
      第39回日本慢性疼痛学会
    • Place of Presentation
      東京
    • Year and Date
      2010-02-26
    • Related Report
      2009 Annual Research Report
  • [Presentation] 短時間の環境圧力の変化が疼痛感覚に与える影響2009

    • Author(s)
      佐藤純
    • Organizer
      第55回日本宇宙航空環境医学会大会
    • Place of Presentation
      岐阜
    • Year and Date
      2009-11-14
    • Related Report
      2009 Annual Research Report
  • [Presentation] 気圧低下曝露がラットの抑うつ行動に与える影響2009

    • Author(s)
      佐藤純
    • Organizer
      第48回日本生気象学会大会
    • Place of Presentation
      つくば
    • Year and Date
      2009-10-30
    • Related Report
      2010 Final Research Report 2009 Annual Research Report
  • [Presentation] Exposure to low atmospheric pressure increases activity of rat spinal trigeminal nucleus neurons- relevance for weather-related headaches?2009

    • Author(s)
      SATO Jun
    • Organizer
      14th Congress of the International Headache Society
    • Place of Presentation
      USA
    • Year and Date
      2009-10-01
    • Related Report
      2010 Final Research Report
  • [Presentation] 痛みと天気、その不思議な関係2009

    • Author(s)
      佐藤純
    • Organizer
      第3回先端医療ヘルスケアセミナー
    • Place of Presentation
      名古屋
    • Year and Date
      2009-09-19
    • Related Report
      2009 Annual Research Report
  • [Presentation] Lowering barometric pressure aggravates anxiety/depression-like behavior in rats2009

    • Author(s)
      佐藤純
    • Organizer
      第32回日本神経科学大会
    • Place of Presentation
      名古屋
    • Year and Date
      2009-09-18
    • Related Report
      2009 Annual Research Report
  • [Presentation] Exposure to low atmospheric pressure increases activity of rat spinal trigeminal nucleus neurons-relevance for weather-related headaches?2009

    • Author(s)
      Karl Messlinger
    • Organizer
      4th Congress of the International Headache Society
    • Place of Presentation
      フィラデルフィア (アメリカ)
    • Year and Date
      2009-09-10
    • Related Report
      2009 Annual Research Report
  • [Presentation] Existence of the Neurons Responding to Barometric Pressure Decrease in the Vestibular Nuclei of Rats2009

    • Author(s)
      舟久保恵美
    • Organizer
      XXXVI International Congress of Physiological Sciences (IPUS2009)
    • Place of Presentation
      京都
    • Year and Date
      2009-08-01
    • Related Report
      2009 Annual Research Report
  • [Presentation] 気圧低下曝露によって生じる健常者の感覚変化2009

    • Author(s)
      舟久保恵美
    • Organizer
      第31回日本疼痛学会
    • Place of Presentation
      名古屋
    • Year and Date
      2009-07-17
    • Related Report
      2009 Annual Research Report
  • [Presentation] 天候変化による疼痛悪化のメカニズムに関する研究-低気圧曝露がヒトの慢性痛に及ぼす影響2009

    • Author(s)
      佐藤純
    • Organizer
      第31回日本疼痛学会
    • Place of Presentation
      名古屋
    • Year and Date
      2009-07-17
    • Related Report
      2009 Annual Research Report
  • [Presentation] 慢性痛患者の全身寒冷曝露に対する痛み感覚と血行動態の変化についての検討2009

    • Author(s)
      櫻井博紀
    • Organizer
      第31回日本疼痛学会
    • Place of Presentation
      名古屋
    • Year and Date
      2009-07-17
    • Related Report
      2009 Annual Research Report
  • [Presentation] 筋の役割に着目した運動器慢性痛に対するリハビリテーション介入の効果2009

    • Author(s)
      森本温子
    • Organizer
      第31回日本疼痛学会
    • Place of Presentation
      名古屋
    • Year and Date
      2009-07-17
    • Related Report
      2009 Annual Research Report
  • [Presentation] 慢性疼痛と自律神経機能2009

    • Author(s)
      佐藤純
    • Organizer
      第38回日本慢性疼痛学会
    • Place of Presentation
      神戸
    • Year and Date
      2009-02-28
    • Related Report
      2008 Annual Research Report
  • [Presentation] 気圧低下曝露がヒトの慢性痛と心循環パラメータに及ぼす影響2008

    • Author(s)
      佐藤純
    • Organizer
      第47回日本生気象学会大会
    • Place of Presentation
      奈良
    • Year and Date
      2008-11-24
    • Related Report
      2008 Annual Research Report
  • [Presentation] Weather change and pain : An animal study of the influences of simulated meteorological changes on automatic nervous system and chronic pain2008

    • Author(s)
      Sato Jun
    • Organizer
      18th International Congress of Biometeorology
    • Place of Presentation
      東京
    • Year and Date
      2008-09-25
    • Related Report
      2008 Annual Research Report
  • [Presentation] Weather change and pain : an animal study of the influences of simulated meteorological changes on automatic nervous system and chronic pain2008

    • Author(s)
      SATO Jun
    • Organizer
      18th International Congress of Biometeorology
    • Place of Presentation
      Tokyo
    • Year and Date
      2008-09-23
    • Related Report
      2010 Final Research Report
  • [Presentation] Lowering barometric pressure at rates and magnitudses in the rangeof natural weather change aggravates neuropathic pain-related behaviors in rats2008

    • Author(s)
      Funakubo Megumi
    • Organizer
      12th World Congress on Pain
    • Place of Presentation
      グラスゴー(スコットランド)
    • Year and Date
      2008-08-18
    • Related Report
      2008 Annual Research Report
  • [Presentation] 天気痛を増強する気圧低下量・速度-神経因性疼痛モデルラットでの検討-.2008

    • Author(s)
      佐藤純
    • Organizer
      第30回日本疼痛学会
    • Place of Presentation
      福岡
    • Year and Date
      2008-07-19
    • Related Report
      2008 Annual Research Report
  • [Presentation] 天気痛を増強する気圧低下量・速度-神経因性疼痛モデルラットでの検討-.2008

    • Author(s)
      佐藤純
    • Organizer
      日本ペインクリニック学会第42回大会
    • Place of Presentation
      福岡
    • Year and Date
      2008-07-18
    • Related Report
      2008 Annual Research Report
  • [Book] からだと温度の辞典2010

    • Author(s)
      佐藤純, 他
    • Total Pages
      640
    • Publisher
      朝倉書店
    • Related Report
      2010 Final Research Report
  • [Book] からだと温度の辞典2010

    • Author(s)
      佐藤純
    • Publisher
      朝倉書店
    • Related Report
      2010 Annual Research Report
  • [Remarks] 佐藤純,読売新聞,くらし教育・健康プフス,2009.6.16

    • Related Report
      2010 Final Research Report
  • [Remarks] 佐藤純,読売新聞,くらし学び・健康プフス,2009.8.13

    • Related Report
      2010 Final Research Report
  • [Patent(Industrial Property Rights)] 人体の雰囲気の気圧を昇圧する方法及びその装置2010

    • Inventor(s)
      佐藤純, 櫻井博紀, 斎藤愛子
    • Industrial Property Rights Holder
      名古屋大学
    • Filing Date
      2010-06-30
    • Related Report
      2010 Final Research Report
  • [Patent(Industrial Property Rights)] 人体の雰囲気の気圧を昇圧する方法及びその装置2010

    • Inventor(s)
      佐藤純櫻井博紀齋藤愛子
    • Industrial Property Rights Holder
      名古屋大学
    • Industrial Property Number
      2010-148903
    • Filing Date
      2010-06-30
    • Related Report
      2010 Annual Research Report

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Published: 2008-04-01   Modified: 2016-04-21  

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