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Clarification of mechanisms of antineoplastic drug-induced painful peripheral neuropathy in human patients with cancer

Research Project

Project/Area Number 20390418
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Anesthesiology/Resuscitation studies
Research InstitutionSapporo Medical University

Principal Investigator

NAMIKI Akiyoshi  Sapporo Medical University, 名誉教授 (00136954)

Co-Investigator(Kenkyū-buntansha) KAWAMATA Tomoyuki  信州大学, 医学部, 准教授 (80336388)
KIYA Tomohiro  札幌医科大学, 医学部, 研究員 (10438046)
NIIYAMA Yukitoshi  札幌医科大学, 医学部, 講師 (90423764)
SAWADA Atsushi  札幌医科大学, 医学部, 研究員 (10551492)
Project Period (FY) 2008 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥18,200,000 (Direct Cost: ¥14,000,000、Indirect Cost: ¥4,200,000)
Fiscal Year 2010: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2009: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2008: ¥10,790,000 (Direct Cost: ¥8,300,000、Indirect Cost: ¥2,490,000)
Keywords悪性腫瘍 / 疼痛 / 化学療法 / L-セリン / L-serine / TRPM8
Research Abstract

Paclitaxel is one of the most commonly used antineoplastic drugs for the treatment of solid tumors. It is often associated with painful peripheral neuropathy. However, the mechanisms have been elucidated. In this study, we examined the involvement of L-serine in paclitaxel-induced peripheral neuropathy. This study suggests that a decrease in satellite cell-derived in the dorsal root ganglion contributed to paclitaxel-induced painful peripheral neuropathy. And intraperitoneal administration of L-serine improved both paclitaxel-induced mechanical allodynia/hyperalgesia. The findings of this study may lead to novel strategies for the treatment of paclitaxel-induced painful peripheral neuropathy in human patients with cancer.

Report

(4 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (12 results)

All 2011 2010 2009 2008

All Journal Article (5 results) (of which Peer Reviewed: 5 results) Presentation (6 results) Book (1 results)

  • [Journal Article] Role of satellite cell-derived L-serine in dorsal root ganglion in paclitaxel-induced painful peripheral neuropathy.2011

    • Author(s)
      Kiya T, Kawamarta T, Namiki A, Yamakage M
    • Journal Title

      Neuroscience 174

      Pages: 190-199

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Role of satellite cell-derived L-serine in dorsal root ganglion in paclitaxel-induced painful peripheral neuropathy.2011

    • Author(s)
      Kiya T, Kawamarta T, Namiki A, et.al.
    • Journal Title

      Neuroscience

      Volume: 174 Pages: 190-9

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Involvement of TRPV1 in endothelin-I-induced pain-like behavior2009

    • Author(s)
      Kawamata T
    • Journal Title

      Neuroreport 20

      Pages: 233-237

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] SB366791, a TRPV1 antagonist, potentiates analgesic effects of systemic morphine on bone cancer pain2009

    • Author(s)
      Niiyama Y
    • Journal Title

      Brit J Anaesth 102

      Pages: 251-258

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Contribution of transient receptor potential vanilloid subfamily I to endothelin-I-induced thermal hyperalgesia2008

    • Author(s)
      Kawamata T
    • Journal Title

      Neuroscience 154

      Pages: 1067-1076

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Presentation] Role of satellite cell-derived L-serine in dorsal root ganglion in paclitaxel-induced painful peripheral neuropathy.2011

    • Author(s)
      Kiya T, Kawamarta T, Yamakage M
    • Organizer
      The 2010 ASA Annual Meeting
    • Place of Presentation
      San Diego, USA
    • Related Report
      2010 Final Research Report
  • [Presentation] Role of satellite cell-derived L-serine in dorsal root ganglion in paclitaxel-induced painful peripheral neuropathy.2010

    • Author(s)
      Kiya T, Kawamarta T, Yamakage M
    • Organizer
      The annual meeting of American Society of Anest hesiologists.
    • Place of Presentation
      San Diego, USA
    • Related Report
      2010 Annual Research Report
  • [Presentation] Analgesic effects of a novel TRPV1 antagonist and its interaction with morphine on bone cancer pain2008

    • Author(s)
      Niiyama Y
    • Organizer
      12th World Congress of Pain
    • Place of Presentation
      Glasgow, U. K.
    • Related Report
      2008 Annual Research Report
  • [Presentation] Expression of phospholipase Cβ3 and β4 in the spinal cord2008

    • Author(s)
      Kawamata T
    • Organizer
      12th World Congress of Pain
    • Place of Presentation
      Glasgow, U. K.
    • Related Report
      2008 Annual Research Report
  • [Presentation] Effects of activat ion of spinal cannabinoid system on bone cancer pain2008

    • Author(s)
      Furuse S
    • Organizer
      Society for Neuroscience 38th Annual Meeting
    • Place of Presentation
      Washington D. C., U.S.A.
    • Related Report
      2008 Annual Research Report
  • [Presentation] Change of TRPM8 expression in a rat model of paclitaxel-induced peripheral neuropathy2008

    • Author(s)
      Kiya T
    • Organizer
      Society for Neuroscience 38th Annual Meeting
    • Place of Presentation
      Washington D. C., U.S.A.
    • Related Report
      2008 Annual Research Report
  • [Book] すぐに役立つ がん患者の症状コントロールに用いられる薬の使い方と注意点2008

    • Author(s)
      並木昭義
    • Total Pages
      137
    • Publisher
      真興交易(株)医書出版部
    • Related Report
      2008 Annual Research Report

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Published: 2008-04-01   Modified: 2016-04-21  

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