| Budget Amount *help |
¥18,200,000 (Direct Cost: ¥14,000,000、Indirect Cost: ¥4,200,000)
Fiscal Year 2011: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2010: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2009: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2008: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
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| Research Abstract |
Using SELDI-TOF MS, we performed protein mass profiling of the sera from the patients with castration-resistant prostate cancer and identified apolipoprotein C-I (ApoC-I), which level increased with disease progression. MicroRNAs (miRNAs) are small non-coding RNAs that regulate gene expression. We examined the functional significance of such miRNAs (miR-145, miR-1 and miR-133a) in prostate cancer cells and identified the novel molecular targets, purine nucleoside phosphorylase (PNP) and Fascin homolog 1 (FSCN1). We showed that lung metastases were suppressed by the use of dendritic cells (DCs) activated by replication-competent, as well as nontransmissible-type, recombinant Sendai viruses (rSeV), in both rat and mouse prostate cancer models.
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