The basic research for elucidation of molecular mechanism of the prostate cancer recurrence and the treatment strategy construction

• Project/Area Number: 20390421
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Urology
• Research Institution: Kanazawa University
• Principal Investigator: NAMIKI Mikio Kanazawa University, 医学系, 教授 (70155985)
• Co-Investigator(Kenkyū-buntansha): MIZOKAMI Atsushi 金沢大学, 附属病院, 講師 (50248580) ; KYO Satoru 金沢大学, 医学系, 講師 (50272969) ; HIGASHI Tatuya 静岡県立大学, 薬学部, 准教授 (90272963)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥19,500,000 (Direct Cost: ¥15,000,000、Indirect Cost: ¥4,500,000); Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2009: ¥6,760,000 (Direct Cost: ¥5,200,000、Indirect Cost: ¥1,560,000); Fiscal Year 2008: ¥11,180,000 (Direct Cost: ¥8,600,000、Indirect Cost: ¥2,580,000)
• Keywords: 前立腺癌 / DHEA / 間質細胞 / トラニラスト / CTEN / パクリタキセル耐性 / 再燃 / アンドロゲン / 再燃前立腺癌 / TGFβ

Research Abstract

1. Adrenal androgen, DHEA, is important for recurrence of prostate cancer. Prostate cancer stromal cells and prostate cancer cells coordinately activate the androgen receptor through synthesis of T and DHT from DHEA. 2. Tranilast inhibits hormone refractory prostate cancer cell proliferation and suppresses TGF-β-associated osteoblastic changes. 3. We identified CTEN, one of important genes that is associated with paclitaxel resistance. Expression of CTEN recovered paclitacel-resistance.

Research Products

• [Journal Article] CTEN/tensin 4 expression induces sensitivity to paclitaxel in prostate cancer. (2010)
  • Author(s): Li, Y., Mizokami, A., izumi, K., Narimoto, K., Namiki , M.(他4名)
  • Journal Title: Prostate 70 Pages: 48-60
  • NAID: 120001828357
  • Peer Reviewed
• [Journal Article] Preliminary results of tranilast treatment for patients with advanced castration-resistant prostate cancer. (2010)
  • Author(s): Izumi, K, Mizokami, A.Namiki, M, et al.
  • Journal Title: Anticancer Research Volume: 30 Pages: 3077-3081
  • Peer Reviewed
• [Journal Article] Tranilast inhibits hormone refractory prostate cancer cell proliferation and suppresses transforming growth factor betal-associated osteoblastic changes. (2009)
  • Author(s): Izumi, K.Mizokami, A.Li, Y.Q.Narimoto, K.Namiki, M.(他6名)
  • Journal Title: Prostate 69 Pages: 1222-1234
  • Peer Reviewed
• [Journal Article] Prostate cancer stromal cells and LNCaP cells coordinately activate the androgen receptor through synthesis of T and DHT from DHEA. (2009)
  • Author(s): Mizokami, A.Kohl E.Izumi, K.Narimoto, K.Takeda, M.Honma, S.Dai, J.Keller, E.Namiki, M.
  • Journal Title: Endocr Relat Cancer 16 Pages: 1139-1155
  • Peer Reviewed
• [Journal Article] Prostate cancer stromal cells and LNCaP cells coordinately activate the androgen receptor through synthesis of T and DHT from DHEA (2009)
  • Author(s): 溝上敦, 並木幹夫, ら
  • Journal Title: Endocrine-Related Cancer 16 Pages: 1139-1155
  • Peer Reviewed
• [Presentation] 再燃前立腺癌に対するトラニラストによる抗腫瘍効果の臨床的検討 (2010)
  • Author(s): 溝上敦、泉浩二、並木幹夫
  • Organizer: 第60回日本泌尿器科学会中部総会
  • Place of Presentation: 愛知県産業労働センター(名古屋) 招待講演
  • Year and Date: 2010-12-01
• [Presentation] 前立腺癌の再燃に対する副腎性アンドロゲンDHEAと前立腺癌間質細胞の役割 (2009)
  • Author(s): 溝上敦、高栄哲、泉浩二、成本一隆、小中弘之、角野佳史、北川育秀、並木幹夫
  • Organizer: 第97回日本泌尿器科学会総会
  • Place of Presentation: 岡山コンベンションセンター(岡山県)
  • Year and Date: 2009-04-17
• [Presentation] 前立腺癌の再燃に対する副腎性アンドロゲンDHEAと前立腺癌間質細胞の役割 (2009)
  • Author(s): 溝上敦, 並木幹夫, ら
  • Organizer: 第97回日本泌尿器科学会総会
  • Place of Presentation: 岡山コンベンションセンター (岡山県)
  • Year and Date: 2009-04-17
• [Presentation] 前立腺癌間質細胞は副腎性アンドロゲンDHEAを変換し、アンドロゲン受容体を活性化する (2009)
  • Author(s): 溝上敦、高栄哲、小中弘之、角野佳史、成本一隆、泉浩二、島崇、並木幹夫
  • Organizer: 第18回泌尿器分子細胞研究会
  • Place of Presentation: 鹿児島大学鶴陵会館(鹿児島県)
  • Year and Date: 2009-02-14
• [Presentation] 前立腺癌間質細胞は副腎性アンドロゲンDHEAを変換し、アンドロゲン受容体を活性化する (2009)
  • Author(s): 溝上敦
  • Organizer: 第18回泌尿器科分子・細胞研究会
  • Place of Presentation: 鹿児島
  • Year and Date: 2009-02-14
• [Presentation] CTEN, A Gene Related with Paclitaxel-resistance and Tumor Progression in Prostate Cancer. (2009)
  • Author(s): 李友強, 溝上敦, 泉浩二, 成本一隆, 並木幹夫
  • Organizer: Advances in Prostate Cancer Research
  • Place of Presentation: The Westin San Diego Hotel (USA)
  • Year and Date: 2009-01-22
• [Presentation] 前立腺癌に対するトラニラストの抗腫瘍効果の検討 (2008)
  • Author(s): 泉浩二、溝上敦、李友強、成本一隆、杉本和宏、北川育秀、角野佳史、小中弘之、高栄哲、並木幹夫
  • Organizer: 第24回前立腺シンポジウム
  • Place of Presentation: 東京コンファレンスセンター(東京都)
  • Year and Date: 2008-12-14
• [Patent(Industrial Property Rights)] 様々な細胞でのDHEAからDHTに変換する酵素の活性測定法 (2008)
  • Inventor(s): 溝上敦,並木幹夫
  • Industrial Property Rights Holder: 金沢大学
  • Filing Date: 2008-07-16
• [Patent(Industrial Property Rights)] 様々な細胞でのDHEAからDHTに変換する酵素の活性測定法 (2008)
  • Inventor(s): 溝上敦, 並木幹夫
  • Industrial Property Rights Holder: 溝上敦, 並木幹夫
  • Filing Date: 2008-07-16