Molecular mechanism of urothelium regulating bladder function

• Project/Area Number: 20390425
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Urology
• Research Institution: Kyoto University
• Principal Investigator: NISHIYAMA Hiroyuki Kyoto University, 大学院・医学研究科, 准教授 (20324642)
• Co-Investigator(Kenkyū-buntansha): OGAWA Osamu 京都大学, 大学院・医学研究科, 教授 (90260611) ; NAKAMURA Eijiro 京都大学, 大学院・医学研究科, 講師 (90293878) ; KANEMATSU Akihiro 京都大学, 大学院・医学研究科, 講師 (90437202) ; YOSHIMURA Kouji 京都大学, 大学院・医学研究科, 講師 (40397542) ; SODA Takeshi 京都大学, 大学院・医学研究科, 助教 (50422928)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥17,420,000 (Direct Cost: ¥13,400,000、Indirect Cost: ¥4,020,000); Fiscal Year 2010: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2009: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2008: ¥7,800,000 (Direct Cost: ¥6,000,000、Indirect Cost: ¥1,800,000)
• Keywords: 排尿障害 / 膀胱機能 / 尿路上皮 / 分子生物学

Research Abstract

In this project, we engaged in clarification of the mechanism underlying change in bladder function with the molecules secreted from urothelium under stimuli. We demonstrated the physiological role of urothelium and the clinical condition of the bladder disease related with dysfunctional urothelium with combination of conventional pharmacological analysis, molecular biological analysis and new voiding behavior analysis.

Research Products

• [Journal Article] Regulation of Connexin 43 by Basic Fibroblast Grwoth Factor in the Bladder : Transcriptional and Behavioral Implications. (2011)
  • Author(s): Negoro H, Kanematsu A, Ogawa O, et al.
  • Journal Title: J Urol. 185 Pages: 2398-2404
  • Peer Reviewed
• [Journal Article] Regulation of connexin 43 by basic fibroblast growth factor in the bladder : transcriptional and behavioral implications (2011)
  • Author(s): H Negoro, et al.
  • Journal Title: The Journal of Urology Volume: In press
  • Peer Reviewed
• [Journal Article] Basic fibroblast growth factor causes urinary bladder overactivity through gap junction generation in the smooth muscle. (2009)
  • Author(s): Imamura M, Kanematsu A, Ogawa O, et al.
  • Journal Title: Am J Physiol Renal Physiol 297 Pages: 46-54
  • Peer Reviewed
• [Journal Article] Basic fibroblast growth factor causes urinary bladder overactivity through gap junction generation in the smooth muscle (2009)
  • Author(s): Masaaki Imamura, et al.
  • Journal Title: American Journal of Physiology and Renal Physiology 297 Pages: 46-54
  • Peer Reviewed
• [Journal Article] Basic fibroblast growth factor modulates proliferation and collagen expression in urinary bladder smooth muscle cells. (2007)
  • Author(s): Imamura M, Kanematsu A, Ogawa O, et al.
  • Journal Title: Am J Physiol Renal Physiol 293
  • Peer Reviewed
• [Presentation] Basic fibroblast growth factor (bFGF) could be a key regulator for myogenic bladder overactivity through gap junction generation in the smooth muscle. (2010)
  • Author(s): Imamura M, Kanematsu A, Ogawa O, et al.
  • Organizer: International Continence Society annual meeting
  • Place of Presentation: Toronto Ontario
• [Presentation] bFGFによる平滑筋gap junction発現を介した過活動膀胱発症機序の解明 (2009)
  • Author(s): 根来宏光
  • Organizer: 第97回日本泌尿器科学会総会
  • Place of Presentation: 岡山
  • Year and Date: 2009-04-17
• [Presentation] BALB/c-Fcgr2b-/-Pdcd1-/- mouse expressing anti-urothelial antibody is a model of autoimmune cystitis (2009)
  • Author(s): Sugino Y, Kanematsu A, Yoshimura K, Ogawa O, et al.
  • Organizer: American Urological Association annual meeting
  • Place of Presentation: Chicago
• [Presentation] Basic fibroblast growth factor (bFGF) could be a key regulator of matrix remodeling and hypersensitivity in obstructed bladder. (2008)
  • Author(s): Imamura M, Kanematsu A, Ogawa O, et al.
  • Organizer: American Academy of Pediatrics annual meeting
  • Place of Presentation: Boston Massachusetts
• [Presentation] Basic fibroblast growth factor (bFGF) promotes bladder smooth muscle cell proliferation and matrix remodeling through ERK1/2 pathway. (2007)
  • Author(s): Imamura M, Kanematsu A, Ogawa O, et al.
  • Organizer: American Urological Association annual meeting
  • Place of Presentation: Anaheim California
• [Remarks] ホームページ等
  • URL: http://www.urology.kuhp.kyoto-u.ac.jp/
• [Remarks]
  • URL: http://www.urology.kuhp.kyoto-u.ac.jp/
• [Remarks]
  • URL: http://www.urology.kuhp.kyoto-u.ac.jp/