| Project/Area Number |
20390426
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Urology
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| Research Institution | Okayama University |
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Principal Investigator |
KUMON Hiromi Okayama University, 大学院・医歯薬学総合研究科, 教授 (30144760)
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| Co-Investigator(Kenkyū-buntansha) |
HUH Namho 岡山大学, 大学院・医歯薬学総合研究科, 教授 (70142023)
MASAKIYO Sakaguchi 岡山大学, 大学院・医歯薬学総合研究科, 准教授 (70379840)
NASU Yasutomo 岡山大学, 病院, 教授 (20237572)
TSUTSUI Ken 岡山大学, 自然生命科学研究センター, 教授 (70108158)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥17,550,000 (Direct Cost: ¥13,500,000、Indirect Cost: ¥4,050,000)
Fiscal Year 2010: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2009: ¥6,630,000 (Direct Cost: ¥5,100,000、Indirect Cost: ¥1,530,000)
Fiscal Year 2008: ¥7,540,000 (Direct Cost: ¥5,800,000、Indirect Cost: ¥1,740,000)
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| Keywords | 不死化関連遺伝子 / Ras / Ras-GTP / Akt / BiP / GRP78 / 前立腺分化 / Bip/GRP78 / 前立腺 / 癌化 |
|---|
| Research Abstract |
We analyzed the molecular function of novel immortalization-related genes, which were identified at Okayama University, in the intracellular Ras signaling and cell growth of prostate normal and cancer cells. In particular, we disclosed that the expression of REIC/Dkk-3, one of the immortalization-related genes, inactivated Akt signaling by down-regulating activated Ras. We also elucidated that the expression of BiP/GRP78, one of molecular chaperones, suppresses the REIC/Dkk-3-induced apoptotic signaling.
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