| Project/Area Number |
20390427
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Urology
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| Research Institution | Kagoshima University |
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Principal Investigator |
NAKAGAWA Masayuki Kagoshima University, 医歯学総合研究科, 教授 (90164144)
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| Co-Investigator(Kenkyū-buntansha) |
ENOKIDA Hideki 鹿児島大学, 医歯学総合研究科, 講師 (80347103)
SEKI Naohiko 千葉大学, 機能ゲノム学, 准教授 (50345013)
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| Co-Investigator(Renkei-kenkyūsha) |
千代丸 剛 鹿児島大学, 医歯科総合研究科, 大学院生
鑪野 秀一 鹿児島大学, 医歯科総合研究科, 大学院生
吉野 裕史 鹿児島大学, 医歯科総合研究科, 大学院生
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| Project Period (FY) |
2008 – 2010
|
| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥19,760,000 (Direct Cost: ¥15,200,000、Indirect Cost: ¥4,560,000)
Fiscal Year 2010: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2009: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2008: ¥13,260,000 (Direct Cost: ¥10,200,000、Indirect Cost: ¥3,060,000)
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| Keywords | マイクロRNA / 尿路上皮癌 / 腫瘍マーカー / 膀胱癌 / 癌抑制遺伝子 / microRNA / FSCN1 / 診断マーカー / がん抑制遺伝子 |
|---|
| Research Abstract |
We screened 667 microRNAs in urothelial carcinoma specimens and identified the profile of down-regulated miRNAs, such as miR-1, miR-133a, and miR-145, which have tumor suppressive function. These miRNAs directly repressed the expression levels of novel oncogenic genes, such as FSCN1, LASP1, and GSTP1. On the other hand, miR-96 and miR-183, which were the top two up-regulated miRNAs in the profile, were subjected to tests for evaluating their ability as urine markers.
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