Abnormal spermatogenesis in IgM/A receptor-deficient mice.

• Project/Area Number: 20390429
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Obstetrics and gynecology
• Research Institution: University of Tsukuba
• Principal Investigator: HONDA Shin-Ichiro University of Tsukuba, 大学院・人間総合科学研究科, 講師 (60360640)
• Research Collaborator: NAOKI Kurita 筑波大学, 大学院・人間総合科学研究科, 大学院生 ; KENTA Usui 筑波大学, 大学院・人間総合科学研究科, 大学院生
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥18,590,000 (Direct Cost: ¥14,300,000、Indirect Cost: ¥4,290,000); Fiscal Year 2010: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2009: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000); Fiscal Year 2008: ¥7,930,000 (Direct Cost: ¥6,100,000、Indirect Cost: ¥1,830,000)
• Keywords: Fc受容体 / IgM / A / 精子形成 / 精子形成異常 / 雄性不妊 / マウス系統 / 精子形戍異常

Research Abstract

Fcα/μR-/-germ cell differentiated to sperm normally after transplantation to WBB6F1-W/W^V mice testis, indicating that the defects of spermatogenesis in Fcα/μR-/- mice were caused by stromal cells of testis, but not by germ cell itself. Newly generated Fcα/μR-/- mice of BALB/c mice background showed normal spermatogenesis, suggesting that the roles of Fcα/μR in spermatogenesis were influenced by strains of mice.

Research Products

• [Journal Article] A critical role of DNAM-1 in the development of acute graft-versus-host disease in mice. (2010)
  • Author(s): Nabekura T, Shibuya K, Takenaka E, Kai H, Shibata K, Yamashita Y, Harada K, Tahara-Hanaoka S, Honda S, Shibuya A.
  • Journal Title: Proc Natl Acad Sci USA 43 Pages: 18593-18598
  • Peer Reviewed
• [Journal Article] Requirement of the cytoplasmic portion for dimer formation of Fcα/μ receptor expressed on cell surface. (2010)
  • Author(s): Cho Y, Honda S, Usui K, Yoshizawa Y, Takagaki K, Shibuya A.
  • Journal Title: Mol Immunol. 47 Pages: 878-882
  • Peer Reviewed
• [Journal Article] Critical role of DNAX accessory molecule-1 (DNAM-1) in the development of acute graft-versus-host disease in mice. (2010)
  • Author(s): Nabekura T, et.al.
  • Journal Title: Proc Natl Acad Sci USA Volume: 107 Pages: 18593-18598
  • Peer Reviewed
• [Journal Article] Enhanced humoral immune responses against T-independent antigens in FcαμR-deficient mice. (2009)
  • Author(s): Honda S, Kurita N, Miyamoto A, Cho Y, Usui K, Takeshita K, Takahashi S, Yasui T, Kikutani H, Kinoshita T, Fujita T, Tahara-Hanaoka S, Shibuya K, Shibuya A.
  • Journal Title: Proc Natl Acad Sci.USA 27 Pages: 11230-11235
  • NAID: 130006949816
  • Peer Reviewed
• [Journal Article] Identification of the Fcα/μR isoform specifically expressed in the kidney tubules. (2009)
  • Author(s): Kurita N, Honda S, Usui K, Shimizu Y, Miyamoto A, Tahara-Hanaoka S, Shibuya K, Shibuya A.
  • Journal Title: Mol Immunol. 46 Pages: 749-753
  • NAID: 120007138354
  • Peer Reviewed
• [Journal Article] Enhanced humoral immune responses against T-independent antigens in Fcα/μR-deficient mice. (2009)
  • Author(s): HONDA S., et al.
  • Journal Title: Proc Natl Acad Sci.USA 27 Pages: 11230-11235
  • NAID: 130006949816
  • Peer Reviewed
• [Journal Article] Requirement of the cytoplasmic portion for dimer formation of Fcα/μ receptor expressed on cell surface. (2009)
  • Author(s): CHO Y., et al.
  • Journal Title: Mol Immunol. 47 Pages: 878-882
  • Peer Reviewed
• [Journal Article] Identification of the Fcα/μ isoform specifically expressed in the kidney, tubules. (2009)
  • Author(s): Kurita N and Honda S, et al
  • Journal Title: Mol. Immunol 46 Pages: 749-753
  • Peer Reviewed
• [Journal Article] Accelerated tumor growth in mice deficient in DNAM-1 receptor. (2008)
  • Author(s): Iguchi-Manaka A, Kai H, Yamashita Y, Shibata K, Tahara-Hanaoka S, Honda S, Yasui T, Kikutani H, Shibuya K, Shibuya A.
  • Journal Title: J Exp Med. 13 Pages: 2959-2964
  • NAID: 120007138364
  • Peer Reviewed
• [Journal Article] Accelerated tumor growth in mice deficient in DNAM-1 receptor. (2008)
  • Author(s): Iguchi-Manaka A, et al
  • Journal Title: J. Exp. Med. 13 Pages: 2959-2964
  • Peer Reviewed
• [Presentation] Regulation of serum IgA production by the Fca/μ, an Fc receptor for IgA and IgM (2010)
  • Author(s): Shin-ichiro Honda
  • Organizer: 第14回国際免疫学会議
  • Place of Presentation: 神戸ポートピアホテル
  • Year and Date: 2010-08-26
• [Presentation] Regulation of serum IgA production by the Fcα/μ, an Fc receptor for IgA and IgM (2010)
  • Author(s): 本多伸一郎, 他
  • Organizer: 第14回国際免疫学会議
  • Place of Presentation: 神戸
• [Presentation] Regulation of serum IgA production by the Fcα/μR, an Fc receptor for IgA and IgM (2009)
  • Author(s): 本多伸一郎, 他
  • Organizer: 第39回 日本免疫学会総会・学術集会
  • Place of Presentation: 大阪
• [Presentation] Regulation of serum IgA production by the Fcα/μR, an Fc receptor for IgA and IgM. (2009)
  • Author(s): HONDA S.
  • Organizer: 第39回 日本免疫学会総会・学術集会
  • Place of Presentation: 大阪
• [Presentation] Immunere sponses by the family of activating and inhibitory myeloid associated-immunoglobulin-like receptors (MAIR). (2008)
  • Author(s): ShibuyaA
  • Organizer: 57th fall Colnference of Korean Association of Immunologists
  • Place of Presentation: Seoul, Korea
  • Year and Date: 2008-11-13
• [Presentation] Accelerated tumor growth in mice deficient in DNAM-1 receptor. (2008)
  • Author(s): ShibuyaA
  • Organizer: 11th meeting of the Society for Natural Immunity
  • Place of Presentation: Fremantle, Australia
  • Year and Date: 2008-08-27
• [Presentation] Enhanced humoral Immune responses against T-independent antigens in Fcα/μR-deficient mice. (2008)
  • Author(s): 渋谷彰、本多伸一郎
  • Organizer: FASEB Summer Research Conference
  • Place of Presentation: New Heaven, USA
  • Year and Date: 2008-08-07
• [Presentation] A novel role of CD155 as a co-stimulatory molecule on CD4+ helper T cells in mice (2008)
  • Author(s): Yumi Yamashita
  • Organizer: 第38回日本免疫学会総会・学術集会
  • Place of Presentation: 京都
  • Year and Date: 2008-08-07
• [Presentation] Enhanced humoral Immune responses against T-independent antigens in Fcα/μR-deficient mice. (2008)
  • Author(s): ShibuyaA
  • Organizer: FASEB Summer Research Conference
  • Place of Presentation: NewHaven, USA
  • Year and Date: 2008-08-07
• [Presentation] Increased anti-PC natural IgM production and resistance against Streptococcus pneuoniae infection in mice deficient in Fcα/μR, an Fc receptor for IgA and IgM (2008)
  • Author(s): 本多伸一郎, 他
  • Organizer: 第38回 日本免疫学会総会・学術集会
  • Place of Presentation: 京都
• [Presentation] Enhanced humoral Immune responses against T-independent a ntigens in Fcα/μ-deficient mice. (2008)
  • Author(s): Shibuya A
  • Organizer: 第38回日本免疫学会総会・学術集会
  • Place of Presentation: 京都
• [Presentation] HONDA Shin-ichiro Iucreased anti-PC natural IgM production and resistance agai nst Streptococcus pneuonige infection in mice deficient in Fcα/μ. an Fc receptor for IgA- and IgM (2008)
  • Author(s): HONDA Shin-ichiro
  • Organizer: 第38回日本免疫学会総会・学術集会
  • Place of Presentation: 京都
• [Presentation] Identification and characterization of a novel inhibitory immunoglobulin-iike renentor, MBIR (2008)
  • Author(s): Satoko Tahara-Hanaoka
  • Organizer: 第38回日本免疫学会総会・学術集会
  • Place of Presentation: 京都
• [Presentation] Prolonged survival of MAIR-I (CD300a)-deficient mice from acute septic peritonitis (2008)
  • Author(s): Chigusa Nakahashi-Oda
  • Organizer: 第38回日本免疫学会総会・学術集会
  • Place of Presentation: 京都
• [Presentation] Involvement of DNAM-1 (CD226) in development of graft-ve rsus-host disease (2008)
  • Author(s): Tsukasa Nabekura
  • Organizer: 第38回日本免疫学会総会・学術集会
  • Place of Presentation: 京都
• [Presentation] Negative regulation of IgA production by the Fcα/μR, an Fcreceptor for IgA and IgM. (2008)
  • Author(s): Naolki: Kurita
  • Organizer: 第38回日本免疫学会総会・学術集会
  • Place of Presentation: 京都
• [Presentation] MAIR - II (CD300d) amplifies TLRs-mediated inflammation and is crucial mediator of murine sepsis model. (2008)
  • Author(s): Naoya Totsuka
  • Organizer: 第38回日本免疫学会総会・学術集会
  • Place of Presentation: 京都
• [Remarks] ホームページ等
  • URL: http://www.md.tsukuba.ac.jp/basic-med/immunology/immunol.index.html
• [Remarks] リポジトリ論文
  • URL: http://www.tulips.tsukuba.ac.jp/dspace/handle/2241/97904/browse-title
• [Remarks] リポジトリ論文URL
  • URL: http://www.tulips.tsukuba.ac.jp/dspace/handle/2241/97904/browse-title
• [Remarks] リポジトリ論文 URL
  • URL: http://www.tulips.tsukuba.acjp/dspace/handle/2241/97904/browse-title
• [Patent(Industrial Property Rights)] Fcα/μレセプターを介する生体機能調節物質のスクリーニング方法 (2008)
  • Inventor(s): 渋谷彰、本多伸一郎
  • Industrial Property Rights Holder: 渋谷彰、本多伸一郎
  • Industrial Property Number: 2008-263584
  • Filing Date: 2008-10-10
• [Patent(Industrial Property Rights)] Fca/uレセプタ-を介する生体機能調節物質のスクリーニング方法 (2008)
  • Inventor(s): 渋谷彰本多伸一郎
  • Industrial Property Rights Holder: 渋谷彰本多伸一郎
  • Industrial Property Number: 2008-263584
  • Acquisition Date: 2008-10-10
  • Overseas