Abnormal spermatogenesis in IgM/A receptor-deficient mice.
Project/Area Number |
20390429
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Research Category |
Grant-in-Aid for Scientific Research (B)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Obstetrics and gynecology
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Research Institution | University of Tsukuba |
Principal Investigator |
HONDA Shin-Ichiro University of Tsukuba, 大学院・人間総合科学研究科, 講師 (60360640)
|
Research Collaborator |
NAOKI Kurita 筑波大学, 大学院・人間総合科学研究科, 大学院生
KENTA Usui 筑波大学, 大学院・人間総合科学研究科, 大学院生
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Project Period (FY) |
2008 – 2010
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Project Status |
Completed (Fiscal Year 2010)
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Budget Amount *help |
¥18,590,000 (Direct Cost: ¥14,300,000、Indirect Cost: ¥4,290,000)
Fiscal Year 2010: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2009: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
Fiscal Year 2008: ¥7,930,000 (Direct Cost: ¥6,100,000、Indirect Cost: ¥1,830,000)
|
Keywords | Fc受容体 / IgM / A / 精子形成 / 精子形成異常 / 雄性不妊 / マウス系統 / 精子形戍異常 |
Research Abstract |
Fcα/μR-/-germ cell differentiated to sperm normally after transplantation to WBB6F1-W/W^V mice testis, indicating that the defects of spermatogenesis in Fcα/μR-/- mice were caused by stromal cells of testis, but not by germ cell itself. Newly generated Fcα/μR-/- mice of BALB/c mice background showed normal spermatogenesis, suggesting that the roles of Fcα/μR in spermatogenesis were influenced by strains of mice.
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Report
(4 results)
Research Products
(33 results)
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[Journal Article] Enhanced humoral immune responses against T-independent antigens in FcαμR-deficient mice.2009
Author(s)
Honda S, Kurita N, Miyamoto A, Cho Y, Usui K, Takeshita K, Takahashi S, Yasui T, Kikutani H, Kinoshita T, Fujita T, Tahara-Hanaoka S, Shibuya K, Shibuya A.
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Journal Title
Proc Natl Acad Sci.USA 27
Pages: 11230-11235
NAID
Related Report
Peer Reviewed
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