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Targeted drug delivery to tumor endothelial surface.

Research Project

Project/Area Number 20390433
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Obstetrics and gynecology
Research InstitutionHamamatsu University School of Medicine

Principal Investigator

SUGIHARA Kazuhiro  Hamamatsu University School of Medicine, 医学部, 准教授 (00265878)

Co-Investigator(Kenkyū-buntansha) KANAYAMA Naohiro  浜松医科大学, 医学部, 教授 (70204550)
ITOH Hiroaki  浜松医科大学, 医学部附属病院, 准教授 (70263085)
MAGATA Yasuhiro  浜松医科大学, 光量子医学研究センター, 教授 (20209399)
KOUMURA Yasuhiro  浜松医科大学, 医学部附属病院, 助教 (50332995)
森島 賀子  浜松医科大学, 医学部, 特任研究員 (70464112)
Project Period (FY) 2008 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥19,890,000 (Direct Cost: ¥15,300,000、Indirect Cost: ¥4,590,000)
Fiscal Year 2010: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2009: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2008: ¥12,220,000 (Direct Cost: ¥9,400,000、Indirect Cost: ¥2,820,000)
Keywords婦人科腫瘍学 / 分子標的治療薬 / 腫瘍新生血管 / Annexin 1 / 糖鎖をmimicするペプチド / イメージングシステム / DDS型悪腫瘍治療薬 / 分子標的治療 / 糖鎖 / スプライシングファクター / 腫瘍血管内皮細胞 / ペプチド / リボゾーム / 肺転移 / リポゾーム
Research Abstract

Among previously identified carbohydrate-mimicry peptides, we found one peptide (Proc Natl Acad Sci USA. 2009), designated as IF7, binds to Annexin 1 (Anxa1), a highly specific tumor endothelial cell surface marker. A synthetic IF7 peptide conjugated with fluorescent Alexa 488 targeted the tumor within several minutes of intravenous injection, which was inhibited by anti-Anxa1 antibody. IF7 conjugated with the anti-cancer drug was injected intravenously into nude mice carrying luciferase-positive tumors produced by human cancer cells. IVIS[○!R] Living 3D Image System showed that IF7-anticancer drug treatment substantially suppressed tumor growth, while in some cases the tumor disappeared. IF7-anticancer drug was effective at low dosages, and mice showed no apparent side effects following drug treatment. Given its extremely specific tumor-targeting activity, IF7 therefore represent a clinically relevant vehicle for anticancer drugs.

Report

(4 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (31 results)

All 2010 2009 2008 Other

All Journal Article (9 results) (of which Peer Reviewed: 9 results) Presentation (20 results) Remarks (1 results) Patent(Industrial Property Rights) (1 results)

  • [Journal Article] Identification of mRNA splicing factors as the endothelial receptor for carbohydrate-dependent lung colonization of cancer cells.2009

    • Author(s)
      Hatakeyama S, Sugihara K, Nakayama J, Akama T, Wong S-M, Kawashima H, Zhang J, Smith D, Ohyarna C, Fukuda M, Fukuda NM
    • Journal Title

      Proc Natl Acad Sci USA.3 106(9)

      Pages: 3095-3100

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Antitumor effect of photodynamic therapy in mice using direct application of Photofrin dissolved in lidocaine jelly2009

    • Author(s)
      Murakami H, Kohno E, Kohmura Y, Ozawa H, Itoh H, SuQihara K, Horiuchi K, Hirano T, Kanavama N
    • Journal Title

      Photodermatol Photoimmunol Photomed. 25(5)

      Pages: 259-263

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] A rare form of extraovarian peritoneal serous papillary carcinoma with solitary tumor in the abdominal wall : a case report and literature review.2009

    • Author(s)
      Matsuura T, Sugihara K, Kohmura Y, Sugimura H, Kanavama N
    • Journal Title

      J Obstet Gynaecol Res. 35(6)

      Pages: 1142-1147

    • NAID

      10027209627

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Inactivation of plasminogen activator inhibitor type 1 by activated factor XII plays a role in the enhancement of fibrinolysis by contact factors in-vitro.2009

    • Author(s)
      Tanaka A, Suzuki Y, SuQihara K, Kanavama N, Urano T
    • Journal Title

      Life Sci.1 85(5-6)

      Pages: 220-225

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Chorangiosis and placental oxygenation.2009

    • Author(s)
      Suzuki K, Itch H, Kimura S, SuQihara K, Yaguchi C, Kobayashi Y, Hirai K, Takeuchi K, Sugimura M, Kanavama N
    • Journal Title

      Congenit Anom. 49(2)

      Pages: 71-76

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Identification of mRNA splicing factors as the endothelial receptor for carbohydrate-dependent lung colonization of cancer cells2009

    • Author(s)
      Hatakeyama S., Sugihara K., et al.
    • Journal Title

      Proc.Natl.Acad.Sci. USA 106(9)

      Pages: 3095-3100

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A rare form of extraovarian peritoneal serous papillary carcinoma with solitary tumor in the abdominal wall : a case report and literature review2009

    • Author(s)
      Matsuura T., Sugihara K., et al.
    • Journal Title

      J Obstet Gynaecol Res. 35(6)

      Pages: 1142-1147

    • NAID

      10027209627

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Antitumor effect of photodynamic therapy in mice using direct application of Photofrin dissolved in lidocaine jelly2009

    • Author(s)
      Murakami H, Sugihara K., et al.
    • Journal Title

      Photodermatol Photoimmunol Photomed. 25(5)

      Pages: 259-263

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Identification of mRNA splicing factors as the endothelial receptor for carbohydrate-dependent lung colonization of cancer cells.2009

    • Author(s)
      Hatakeyama S
    • Journal Title

      Proc. Natl. Acad. Sci. USA 106(9)

      Pages: 3095-3100

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Presentation] 癌治療への新しい取り組み2010

    • Author(s)
      杉原一廣
    • Organizer
      第8回静岡がん治療フォーラム
    • Place of Presentation
      浜松
    • Year and Date
      2010-10-08
    • Related Report
      2010 Final Research Report
  • [Presentation] 癌治療への新しい取り組み2010

    • Author(s)
      杉原一廣
    • Organizer
      第8回静岡がん治療フォーラム
    • Place of Presentation
      ホテルクラウンパレス浜松
    • Year and Date
      2010-10-08
    • Related Report
      2010 Annual Research Report
  • [Presentation] 糖鎖をmimicするペプチドIF7を用いた新規DDS型悪性腫瘍治療薬2010

    • Author(s)
      杉原一廣
    • Organizer
      第69回日本癌学会学術総会(シンポジウム)
    • Place of Presentation
      大阪国際会議場
    • Year and Date
      2010-09-23
    • Related Report
      2010 Annual Research Report
  • [Presentation] 糖鎖をmimicするペプチドを用いた新規DDS型悪性腫瘍治療薬の開発2010

    • Author(s)
      杉原一廣
    • Organizer
      第9回日本婦人科がん分子標的研究会学術集会
    • Place of Presentation
      大津
    • Year and Date
      2010-09-10
    • Related Report
      2010 Final Research Report
  • [Presentation] 糖鎖をmimicするペプチドを用いた新規DDS型悪性腫瘍治療薬の開発2010

    • Author(s)
      杉原一廣
    • Organizer
      第9回日本婦人科がん分子標的研究会学術集会
    • Place of Presentation
      大津プリンスホテル
    • Year and Date
      2010-09-10
    • Related Report
      2010 Annual Research Report
  • [Presentation] 糖鎖をmimicするペプチドを用いた新規DDS型悪性腫瘍治療薬の開発2010

    • Author(s)
      杉原一廣
    • Organizer
      第20回日本サイトメトリー学会学術集会(ワークショップ)
    • Place of Presentation
      東京慈恵会医科大学大学
    • Year and Date
      2010-06-26
    • Related Report
      2010 Annual Research Report
  • [Presentation] 糖鎖をmimicするペプチドを用いた新規DDS型悪性腫瘍治療薬の開発ワークショップ:蛋白質および糖鎖解析によるバイオマーカー探索2010

    • Author(s)
      杉原一廣
    • Organizer
      第20回日本サイトメトリー学会学術集会東京
    • Place of Presentation
      東京
    • Related Report
      2010 Final Research Report
  • [Presentation] 糖鎖をmimicするペプチドIF7を用いた新規DDS型悪性腫瘍治療薬2010

    • Author(s)
      杉原一廣
    • Organizer
      第69回日本癌学会学術総会
    • Place of Presentation
      大阪
    • Related Report
      2010 Final Research Report
  • [Presentation] 糖鎖と糖鎖をリガンドとする受容体を標的とする癌治療薬の開発2009

    • Author(s)
      杉原一廣
    • Organizer
      Recent Advance in Tumor Angiogenesis 2009
    • Place of Presentation
      浜松
    • Year and Date
      2009-10-31
    • Related Report
      2010 Final Research Report
  • [Presentation] 分子をmimicするペプチドを用いた研究2009

    • Author(s)
      杉原一廣
    • Organizer
      第27回周産期医療研究会
    • Place of Presentation
      秋田
    • Year and Date
      2009-10-02
    • Related Report
      2010 Final Research Report
  • [Presentation] 基礎研究から創薬へ2009

    • Author(s)
      杉原一廣
    • Organizer
      平成21年キッセイ薬品工業中央研究所講演会
    • Place of Presentation
      長野
    • Year and Date
      2009-08-20
    • Related Report
      2010 Final Research Report
  • [Presentation] 糖鎖をmimicするペプチドを用いた分子標的研究2009

    • Author(s)
      杉原一廣
    • Organizer
      第8回日本婦人科がん分子標的研究会
    • Place of Presentation
      福岡
    • Year and Date
      2009-07-03
    • Related Report
      2010 Final Research Report
  • [Presentation] 糖鎖を mimic するペプチドを用いた分子標的研究2009

    • Author(s)
      杉原一廣, 他
    • Organizer
      第8回日本婦人科がん分子標的研究会
    • Place of Presentation
      福岡・博多エクセルホテル東急
    • Year and Date
      2009-07-03
    • Related Report
      2009 Annual Research Report
  • [Presentation] 「新たな治療を求めて」教育セミナー:糖鎖をmimicするペプチドをtargeting-vehicleとした新規分子標的治療薬2009

    • Author(s)
      杉原一廣
    • Organizer
      第47回日本癌治療学会学術集会
    • Place of Presentation
      横浜
    • Related Report
      2010 Final Research Report
  • [Presentation] 「新たな治療を求めて」教育セミナー糖鎖を mimic するペプチドを targeting vehicle とした新規分子標的治療薬2009

    • Author(s)
      杉原一廣
    • Organizer
      第47回日本癌治療学会学術集会
    • Place of Presentation
      横浜・パシフィコ横浜
    • Related Report
      2009 Annual Research Report
  • [Presentation] 糖鎖をmimicするペプチドを用いた分子標的治療薬2008

    • Author(s)
      杉原一廣
    • Organizer
      第46回日本癌治療学会総会
    • Place of Presentation
      名古屋国際会議場
    • Year and Date
      2008-10-30
    • Related Report
      2008 Annual Research Report
  • [Presentation] 糖鎖をmimicするペプチドを用いた分子標的癌治療薬2008

    • Author(s)
      杉原一廣
    • Organizer
      第60回日本産科婦人科学会・総会・学術講演会
    • Place of Presentation
      横浜
    • Related Report
      2010 Final Research Report
  • [Presentation] Targeted apoptosis of tumor vasculature by carbohydrate-mimicy peptide.2008

    • Author(s)
      Hatakeyama S, Sugihara K, et al.
    • Organizer
      The 6th International Glyco T 2008 meeting in Atlanta.
    • Place of Presentation
      Georgia, USA.
    • Related Report
      2010 Final Research Report
  • [Presentation] 糖鎖をmimicするペプチドを用い腫瘍血管内皮を標的とする分子標的治療薬2008

    • Author(s)
      杉原一廣
    • Organizer
      第44回日本婦人科腫瘍学会学術集会・第7回日本婦人科がん分子標的研究会
    • Place of Presentation
      名古屋
    • Related Report
      2010 Final Research Report
  • [Presentation] 糖鎖をmimicするペプチドを用いた分子標的治療薬2008

    • Author(s)
      杉原一廣
    • Organizer
      第46回日本癌治療学会総会
    • Place of Presentation
      名古屋
    • Related Report
      2010 Final Research Report
  • [Remarks] ホームページ

    • URL

      http://www.hama-med.ac.jp/uni_introduction_report_souran_07161504.hhnl

    • Related Report
      2010 Final Research Report
  • [Patent(Industrial Property Rights)] 「METHODS AND COMPOSITIONS RELATED TO ANNEXIN 1-BINDING COMPOUNDS」(腫瘍新生血管内皮を標的とする新規抗癌剤)2009

    • Inventor(s)
      杉原一廣, 他
    • Industrial Property Rights Holder
      杉原一廣, 他
    • Filing Date
      2009-12-23
    • Related Report
      2010 Final Research Report

URL: 

Published: 2008-04-01   Modified: 2016-04-21  

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