| Project/Area Number |
20390434
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | Kyoto University |
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Principal Investigator |
FUJIWARA Hiroshi Kyoto University, 医学研究科, 准教授 (30252456)
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| Co-Investigator(Kenkyū-buntansha) |
FUJITA Jun 京都大学, 医学研究科, 教授 (50173430)
NISHI Eiichiro 京都大学, 医学研究科, 准教授 (30362528)
NISHIO Takeshi 京都大学, 医学研究科, 助教 (70303790)
HATTORI Akira 京都大学, 薬学研究科, 准教授 (50300893)
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| Co-Investigator(Renkei-kenkyūsha) |
TAKAO Yumi 京都大学, 医学研究科, 助教 (20447957)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥19,110,000 (Direct Cost: ¥14,700,000、Indirect Cost: ¥4,410,000)
Fiscal Year 2010: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2009: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000)
Fiscal Year 2008: ¥7,280,000 (Direct Cost: ¥5,600,000、Indirect Cost: ¥1,680,000)
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| Keywords | 組織再構築 / 黄体形成 / 胎盤形成 / 胚着床 / 妊娠 / 末梢血単核球 / 血小板 / 子宮内膜 / 絨毛外栄養膜細胞 |
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| Research Abstract |
Although it has been widely accepted that adequate endometrial differentiation for embryo implantation is induced by ovarian sex steroid hormones, the precise molecular mechanism(s) concerning human embryo attachment to endometrial epithelium remains unclear. Accordingly, implantation failure in patients treated with in vitro fertilization and embryo transfer has been increasingly focused on in the field of assisted reproductive technology. On the other hand, during the past several decades the mechanisms for establishing maternal immune tolerance against embryo have been investigated in reproductive immunology. Recently, accumulating evidence suggests that activated immune cells actively contribute to establishment of pregnancy. In accordance with it, we found that peripheral blood immune cells positively affect function and differentiation of maternal endometrium and corpus luteum of pregnancy to facilitate embryo implantation during early pregnancy. In addition, platelets were shown to regulate vascular remodeling process in corpus luteum and placental formation. Based on these findings, we have successfully developed a new therapy for patients with implantation failure using autologous peripheral blood immune cells.
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