Development of a novel animal model of endometriosis using magnetic materials

• Project/Area Number: 20390436
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Obstetrics and gynecology
• Research Institution: Keio University
• Principal Investigator: MARUYAMA Tetsuo Keio University, 医学部, 講師 (10209702)
• Co-Investigator(Kenkyū-buntansha): UCHIDA Hiroshi 慶應義塾大学, 医学部, 助教 (90286534) ; KAJITANI Takashi 帝京大学, 医学部, 助教 (60407111)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥19,760,000 (Direct Cost: ¥15,200,000、Indirect Cost: ¥4,560,000); Fiscal Year 2010: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000); Fiscal Year 2009: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000); Fiscal Year 2008: ¥12,610,000 (Direct Cost: ¥9,700,000、Indirect Cost: ¥2,910,000)
• Keywords: 子宮内膜症 / 応用動物 / 幹細胞 / 血管新生 / 幹組胞

Research Abstract

The aim of this research project was to develop a novel animal model of endometriosis using magnetic materials which enables non-invasive and real-time of assessment of the endometriotic lesion by in vivo imaging. We first have developed a lentivirus vector enabling the expression of a non-functional surface marker and fluorescent and luminescent proteins in infected cells. We then successfully isolated the infected endometrial cells and accumulated them to the specific site in vivo using magnetic materials. Finally, we were able to assess the behavior of the reconstructed lesion in non-invasive and real-time manner using in vivo imaging system.

Research Products

• [Journal Article] ミニ・シンポジウム2「子宮内膜幹細胞と子宮内膜症」 (2011)
  • Author(s): 丸山哲夫
  • Journal Title: 第1回Asian Conference on Endometriosis Mini-symposium : Endometriosisi reseach in Japan Prog.Med.別刷り Volume: 31 Pages: 621-628
• [Journal Article] OCT4 expression in human uterine myometrial stem/progenitor cells. (2010)
  • Author(s): Ono M, Kajitani T, Uchida H, Arase T, Oda H, Nishikawa-Uchida S, Masuda H, Nagashima T, Yoshimura Y, Maruyama T
  • Journal Title: Hum Reprod. 25(8) Pages: 2059-2067
  • Peer Reviewed
• [Journal Article] Human uterine stem/progenitor cells : their possible role in uterine physiology and pathology. (2010)
  • Author(s): Maruyama T, Masuda H, Ono M, Kajitani T, Yoshimura Y
  • Journal Title: Reproduction. 140 Pages: 11-22
  • Peer Reviewed
• [Journal Article] Stem Cell-Like Properties of the Endometrial Side Population : Implication in Endometrial Regeneration. (2010)
  • Author(s): Masuda H, Matsuzaki Y, Hiratsu E, Ono M, Nagashima T, Kajitani T, Arase T, Oda H, Uchida H, Asada H, Ito M, Yoshimura Y, Maruyama T, Okano H
  • Journal Title: PLoS ONE. 5(4)
  • Peer Reviewed
• [Journal Article] Stem/progenitor cells and the regeneration potentials the human uterus. (2010)
  • Author(s): Maruyama T
  • Journal Title: Reprod Med Biol. 9 Pages: 9-16
  • NAID: 10027049934
  • Peer Reviewed
• [Journal Article] OCT4 expression in human uterine myometrial stem progenitor cells. (2010)
  • Author(s): Ono M, Kajitani T, Uchida H, Arase T, Oda H, Nishikawa-Uchida S, Masuda H, Nagashima T, Yoshimura Y, Maruyama T
  • Journal Title: Hum Reprod. Volume: 25 Pages: 2059-2067
  • Peer Reviewed
• [Journal Article] Human uterine stem/progenitor cells : their possible role in uterine physiology and pathology. (2010)
  • Author(s): Maruyama T, Masuda H, Ono M, Kajitani T, Yoshimura Y
  • Journal Title: Reproduction. Volume: 140 Pages: 11-22
  • Peer Reviewed
• [Journal Article] Stem Cell-Like Properties of the Endometrial Side Population : Implication in Endometrial Regeneration. (2010)
  • Author(s): Masuda H, Matsuzaki Y, Hiratsu E, Ono M, Nagashima T, Kajitani T, Arase T, Oda H, Uchida H, Asada H, Ito M, Yoshimura Y, Maruyama T, Okano H
  • Journal Title: PLoS ONE. Volume: 5
  • Peer Reviewed
• [Journal Article] Stem/progenitor cells and the regeneration potentials the human uterus. (2010)
  • Author(s): Maruyama T
  • Journal Title: Reprod Med Biol. Volume: 9 Pages: 9-16
  • NAID: 10027049934
  • Peer Reviewed
• [Journal Article] シンポジウム3「周産期医療と再生医学」産婦人科医療と再生医療ソース-ヒト子宮由来幹細胞- (2010)
  • Author(s): 丸山哲夫
  • Journal Title: 日本周産期・新生児医学会雑誌 Volume: 46 Pages: 1008-1010
• [Journal Article] 子宮における幹細胞 (2010)
  • Author(s): 丸山哲夫
  • Journal Title: 産婦人科の実際 Volume: 59 Pages: 1381-1387
  • NAID: 40017287076
• [Journal Article] ヒト子宮における幹細胞 (2010)
  • Author(s): 丸山哲夫
  • Journal Title: 日本生殖内分泌学会雑誌 Volume: 15 Pages: 25-27
  • NAID: 40017350216
• [Journal Article] Hypothalamic dysfunction in a female with isolated hypogonadotropic hypogonadism and compound heterozygous TACR3 mutation and clinical manifestation in her heterozygous mother. (2010)
  • Author(s): Fukami M, Maruyama T, Deteki S, Sato N, Yoshimura Y, Ogata T
  • Journal Title: Horm Res Paediatr. 73 Pages: 477-481
  • Peer Reviewed
• [Journal Article] Stem cell-like properties of the endometrial side population : implication in endometrial regeneration. (2010)
  • Author(s): Masuda H, Matsuzaki Y, Hiratsu E, Ono M, Nagashima T, Kajitani T, Arase T, Oda H, Uchida H, Asada H, Ito M, Yoshimura Y, Maruyama T, Okano H
  • Journal Title: PLoS ONE. 5
  • Peer Reviewed
• [Journal Article] Therapeutic Strategies for Implantation Failure due to Endometrial Dysfunction. (2009)
  • Author(s): Maruyama T
  • Journal Title: J Mamm Ova Res. 26(3) Pages: 129-133
  • NAID: 10026349767
  • Peer Reviewed
• [Journal Article] The UDP-glucose recepter P2RY14 triggers innate mucosal immunity in the female reproductive tract by inducing IL-8. (2009)
  • Author(s): Arase T, Uchida H, Kajitani T, Ono M, TamakiK, Oda H, Nishikawa S, Kagami M, Nagashima T, Masuda H, Asada H, Yoshimura Y, Maruyama T
  • Journal Title: J Immunol. 182(11) Pages: 7074-7084
  • Peer Reviewed
• [Journal Article] Epigenetic Treatment in Assisted Human Embryo Implantation. (2009)
  • Author(s): Uchida H, Maruyama T, Kagami M, Oda H, Nishikawa S, Kajitani T, Asada H, Yoshimura Y
  • Journal Title: J.Mamm.Ova Res. 26 Pages: 116-121
  • NAID: 130004436751
  • Peer Reviewed
• [Journal Article] Therapeutic Strategies for Implantation Failure due to Endometrial Dysfunction. (2009)
  • Author(s): Maruyama T
  • Journal Title: J.Mamm.Ova Res. 26 Pages: 129-133
  • NAID: 10026349767
  • Peer Reviewed
• [Journal Article] The UDP-glucose recepter P2RY14 triggers innate mucosal immunity in the female reproductive tract by inducing IL-8. (2009)
  • Author(s): Arase T, Uchida H, Kajitani T, Ono M, Tamaki K, Oda H, Nishikawa S, Kagami M, Nagashima T, Masuda H, Asada H, Yoshimura Y, Maruyama T
  • Journal Title: J Immunol. 182 Pages: 7074-7084
  • Peer Reviewed
• [Journal Article] The UDP-glucose receptor P2RY14 triggers innate mucosal immunity in the female reproductive tract by inducing IL-8. (2009)
  • Author(s): Arase T, Uchida H, Kajitani T, Ono M, Tamaki K, Oda H, Nishikawa S, Kagami M, Nagashima T, Masuda H, Asada H, Yoshimura Y, Maruyama T
  • Journal Title: The Journal of Immunology (In press)
  • Peer Reviewed
• [Journal Article] Molecular and cellular mechanisms for defferentiation and regeneration of the uterine endometrium. (2008)
  • Author(s): Maruyama T, Yoshimura Y
  • Journal Title: Endocrine J. 55(5) Pages: 795-810
  • Peer Reviewed
• [Journal Article] In vivo Imaging in Humanized Mice. (2008)
  • Author(s): Masuda H, Okano. J.H, Maruyama T, Yoshimura Y, Okano H, Matsuzaki Y
  • Journal Title: Current Topics in Microbiology and Immunology 324 Pages: 179-196
  • Peer Reviewed
• [Journal Article] Activation of SRC kinase and phosphorylation of STAT5 are required for decidual transformation of human endometrial stromal cells. (2008)
  • Author(s): Nagashima T, Maruyama T, Uchida H, Kajitani T, Arase T, Ono M, Oda H, Kagami M, Masuda H, Nishikawa S, Asada H, Yoshimura Y
  • Journal Title: Endocrinology. 149(3) Pages: 1227-1234
  • Peer Reviewed
• [Journal Article] Glycodelin blocks progression to S phase and inhibits cell growth : a possible progesterone-induced regulator for endometrial epithelial cell growth. (2008)
  • Author(s): Ohta K, Maruyama T, Uchida H, Ono M, Nagashima T, Arase T, Kajitani T, Oda H, Morita M, Yoshimura Y
  • Journal Title: Mol Hum Reprod. 14(1) Pages: 17-22
  • Peer Reviewed
• [Journal Article] Regeneration and adult stem cells in the human female reproductive tract. (2008)
  • Author(s): Ono M, Maruyama T, Yoshimura Y
  • Journal Title: Stem Cells and Cloning. 1 Pages: 23-29
  • NAID: 110006958167
  • Peer Reviewed
• [Journal Article] Analysis of serum FSH bioactivity in a patient with an FSH-se creting pituitary microadenoma and multicystic ovaries : A casereport. (2008)
  • Author(s): Kajitani T, Liu s, Maruyam a T, Uchida H, Sakurai R, Masuda H, Nagashima T, O no M, Arase T, Yoshimura Y
  • Journal Title: Human reproduction (Oxford, England) 23 Pages: 435-439
  • Peer Reviewed
• [Journal Article] Molecular and cellular mechanisms for differentiation and regeneration of the uterine endometrium. (2008)
  • Author(s): Maruyama T, Yoshimura Y
  • Journal Title: Endocrine iournal 55 Pages: 795-810
  • NAID: 10024422609
  • Peer Reviewed
• [Journal Article] In vivo imaging in humanized mice. (2008)
  • Author(s): Masuda H, Okano HJ, Maruyama T, Yoshimura Y, Okano H, Matsuzaki Y
  • Journal Title: Current topics in microbiology and immunology 324 Pages: 179-196
  • Peer Reviewed
• [Journal Article] Activation of SRC kinase and phosphorylation of signal transducer and activator of transcription-5 are required for decidual transformation of human endometrial stromal cells. (2008)
  • Author(s): Nagashima T, Maruyama T, Uchida H, Kajitani T, Arase T, Ono M, Oda H, Kagami M, Masuda H, Nishikawa S, Asada H, Yoshimura Y
  • Journal Title: Endocrinology 149 Pages: 1227-1234
  • Peer Reviewed
• [Journal Article] Glycodelin blocks progression to S phase and inhibits cell growth : a possible progesterone-induced regulator for endometrial epithelial cell growth. (2008)
  • Author(s): Ohta K, Maruyama T, Uchid a H, Ono M, Nagashima T, Arase T, Kajitani T, 0da H, Morita M, Yoshimura Y
  • Journal Title: Molecular human reproduction 14 Pages: 17-22
  • Peer Reviewed
• [Journal Article] Regeneration and adult stem cells in the human female reproductive tract. (2008)
  • Author(s): Ono M, Maruyama T, Yoshimura Y
  • Journal Title: Stem Cells and Cloning 1 Pages: 23-29
  • NAID: 110006958167
  • Peer Reviewed
• [Journal Article] Pregnancy outcomes of reciprocal translocation carriers who have a history of repeated pregnancy loss. (2008)
  • Author(s): Ozawa N, Maruyama T, Nagashima T, Ono M, Arase T, Ishimoto H, Yoshimura Y
  • Journal Title: Fertil Steril 90 Pages: 1301-1304
  • Peer Reviewed
• [Journal Article] Subsequent pregnancy outcomes in recurrent miscarriage patients with a paternal or maternal carrier of a structural chromosome rearrangement. (2008)
  • Author(s): Sugiura-Ogasawara M, Aoki K, Fujita T, Kawaguchi R, Maruyama T, Ozawa N, Sugi T, Takeshita T, Saito S
  • Journal Title: J Hum Genet 53 Pages: 622-628
  • NAID: 10021249730
  • Peer Reviewed
• [Journal Article] 婦人科疾患の診断・治療・管理 内分泌疾患 月経異常を伴う内分泌疾患 多嚢胞性卵巣症候群. (2008)
  • Author(s): 丸山哲夫, 吉村泰典
  • Journal Title: 日本産科婦人科学会雑誌 60
  • Peer Reviewed
• [Journal Article] 【思春期の諸問題】排卵障害. (2008)
  • Author(s): 丸山哲夫, 小田英之, 西川明花, 各務真紀, 内田 浩, 吉村泰典
  • Journal Title: 産科と婦人科 75 Pages: 529-536
  • Peer Reviewed
• [Journal Article] 【ハイポキシア生物学 酸素代謝からみる生命現象の方程式】胎盤形成と酸素分圧. (2008)
  • Author(s): 丸山哲夫, 小野政徳, 吉村泰典
  • Journal Title: 医学のあゆみ 225 Pages: 1323-1326
  • Peer Reviewed
• [Journal Article] 【産婦人科ホルモン療法マニュアル】生殖内分泌・不妊 無月経. (2008)
  • Author(s): 丸山哲夫, 西川明花, 小田英之, 荒瀬 透, 小野政徳, 各務真紀, 内田 浩, 吉村泰典
  • Journal Title: 産科と婦人科 75 Pages: 8-14
  • Peer Reviewed
• [Journal Article] 【子宮内膜の機能と生殖医療 その最前線】子宮内膜脱落膜化の機序の解明 チロシンキナーゼSRCの役割と意義. (2008)
  • Author(s): 丸山哲夫, 長島 隆, 梶谷 宇, 内田 浩, 吉村泰典
  • Journal Title: 産婦人科の実際 57 Pages: 193-198
  • Peer Reviewed
• [Journal Article] 【ホルモン療法 最近の話題】月経異常を伴う内分泌疾患. (2008)
  • Author(s): 内田 浩, 荒瀬 透, 小野政徳, 各務真紀, 小田英之, 西川明花, 丸山哲夫, 吉村泰典
  • Journal Title: 産婦人科治療 96 Pages: 163-168
  • Peer Reviewed
• [Journal Article] 精査により診断に至った重症慢性骨盤痛を伴う異所性子宮内膜症の2例. (2008)
  • Author(s): 古谷正敬, 浅田弘法, 内田 浩, 久慈直昭, 丸山哲夫, 青木大輔, 吉村泰典, 大東貴志, 木挽貢慈, 升田博隆, 青木 類, 中村修三
  • Journal Title: エンドメトリオージス研究会会誌 29 Pages: 147-151
  • Peer Reviewed
• [Journal Article] 着床期特異的蛋白glycodelinによる子宮内膜腺上皮細胞の増殖機能制御. (2008)
  • Author(s): 太田邦明, 丸山哲夫, 内田 浩, 小野政徳, 荒瀬 透, 長島隆, 青木大輔, 森田峰人, 吉村泰典
  • Journal Title: 日本生殖内分泌学会雑誌 13 Pages: 43-47
  • Peer Reviewed
• [Journal Article] 妊娠子宮における子宮筋Side Population細胞の役割. (2008)
  • Author(s): 小野政徳, 丸山哲夫, 梶谷 宇, 内田 浩, 荒瀬 透, 各務真紀, 小田英之, 西川明花, 升田博隆, 長島 隆, 太田邦明, 伊藤 守, 浅田弘法, 岡野栄之, 松崎有未, 吉村泰典
  • Journal Title: 日本生殖内分泌学会雑誌 13 Pages: 25-29
  • NAID: 10021262312
  • Peer Reviewed
• [Journal Article] 【生殖医療と再生医療における倫理】ヒト雌性生殖器官の再生とモデル動物の確立. (2008)
  • Author(s): 小野政徳, 升田博隆, 丸山哲夫, 吉村泰典, 松崎有未, 岡野栄之
  • Journal Title: 再生医療 7 Pages: 137-141
  • Peer Reviewed
• [Journal Article] 子宮内膜症・腺筋症由来疼痛に関連する遺伝子の発現解析. (2008)
  • Author(s): 梶谷 宇, 丸山哲夫, 浅田弘法, 小野政徳, 荒瀬 透, 小田英之, 西川明花, 内田 浩, 吉村泰典
  • Journal Title: エンドメトリオージス研究会会誌 29 Pages: 91-93
  • Peer Reviewed
• [Journal Article] 【子宮内膜症の診療】異所性子宮内膜症. (2008)
  • Author(s): 浅田弘法, 古谷正敬, 西尾 浩, 升田博隆, 内田 浩, 丸山哲夫, 梶谷 宇, 木挽貢慈, 吉村泰典
  • Journal Title: 産婦人科治療 96 Pages: 241-247
  • Peer Reviewed
• [Presentation] 子宮内膜症の幹細胞説 (2011)
  • Author(s): 丸山哲夫
  • Organizer: 産婦人科スプリングフォーラム
  • Place of Presentation: 京都府京都市・京都平安ホテル(招請講演)
• [Presentation] 子宮内膜症の幹細胞説 (2011)
  • Author(s): 丸山哲夫
  • Organizer: 産婦人科スプリングフォーラム
  • Place of Presentation: 京都府京都市
• [Presentation] Human uterine stem/progenitor cells. Program in Developmental biology (2010)
  • Author(s): Tetsuo Maruyama
  • Organizer: Baylor College of Medicine(BCM)
  • Place of Presentation: Huston, USA(招請講演)
  • Year and Date: 2010-10-21
• [Presentation] Human uterine stem/progenitor cells. (2010)
  • Author(s): Tetsuo Maruyama
  • Organizer: Program in Developmental biology, Baylor College of Medicine(BCM)
  • Place of Presentation: Huston, USA
  • Year and Date: 2010-10-21
• [Presentation] 幹細胞からみた子宮内膜症の発症・伸展メカニズム (2010)
  • Author(s): 丸山哲夫
  • Organizer: 第2回婦人科ホルモン依存性疾患研究会
  • Place of Presentation: 東京
  • Year and Date: 2010-05-08
• [Presentation] Possible involvement of endometrial stem/progenitor cells in the pathogenesis of endocetriosis. (2010)
  • Author(s): Tetsuo Maruyama, Hirotaka Masuda, Takashi Nagashima, Takashi Kajitani, Masanori Ono, Sayaka Nishikawa-Uchida Hideyuki Oda, Kaoru Miyazaki, Toru Arase, Maki Kagami, Hiroshi Uchida, Hironori Asada, Yasunori Yoshimura
  • Organizer: The First Asian Conference on Endometriosis(ACE).
  • Place of Presentation: Shanghai, China(招請講演)
• [Presentation] 産婦人科医療と再生医療ソース-ヒト子宮由来幹細胞- (2010)
  • Author(s): 丸山哲夫
  • Organizer: 第46回日本周産期・新生児医学会
  • Place of Presentation: 兵庫県神戸市・神戸国際会議場(招請講演/シンポジウム)
• [Presentation] Somatic Stem Cells in the myometrium and its putative implication in myoma formation. (2010)
  • Author(s): Tetsuo Maruyama
  • Organizer: 26th European Society of Human Reproduction & Enbryology(ESHRE)
  • Place of Presentation: Rome, Italy(招請講演)
• [Presentation] Possible involvement of endometrial stem/progenitor cells in the pathogenesis of endocetriosis. (2010)
  • Author(s): Tetsuo Maruyama, Hirotaka Masuda, Takashi Nagashima, Takashi Kajitani, Masanori Ono, Sayaka Nishikawa-Uchida, Hideyuki Oda, Kaoru Miyazaki, Toru Arase, Maki Kagami, Hiroshi Uchida, Hironori Asada, Yasunori Yoshimura
  • Organizer: The First Asian Conference on Endometriosis(ACE)
  • Place of Presentation: Shanghai, China(招請講演)
• [Presentation] Prospective isolation and functional analysis of stem/progenitor cells from the human uterine myometrium. (2010)
  • Author(s): Masanori Ono, Tetsuo Maruyama, Takashi Kajitani, Hiroshi Uchida, Hideyki Oda, Sayaka Nishikawa-Uchida, Kaoru Miyazaki, Takashi Nagashima, Hirotaka Masuda, Hideyuki Okano, Yumi Matsuzaki, Yasunori Yoshimura
  • Organizer: 8th International Society for Stem Cell Research(ISSCR)
  • Place of Presentation: San Francisco, CA USA
• [Presentation] 産婦人科医療と再生医療ソース-ヒト子宮由来幹細胞- (2010)
  • Author(s): 丸山哲夫
  • Organizer: 第46回日本周産期・新生児医学会
  • Place of Presentation: 兵庫県神戸市
• [Presentation] Cell surface marker-based isolation and function and functional analysis of human myometrial stem cells. (2010)
  • Author(s): Masanori Ono, Tetsuo Maruyama, Hiroshi Uchida, Hideyuki Oda, Sayaka Nishikawa, Maki Kagami, Toru Arase, Takashi Nagashima, Hirotaka Masuda, Hironori Asada, Daisuke Aoki, Yasunori Yoshimura
  • Organizer: 第62回日本産科婦人科学会International Session
  • Place of Presentation: 東京
• [Presentation] Animal model for reconstructed functional human endometrium: Potential for drug testing and gene-target validation. (2009)
  • Author(s): Tetsuo Maruyama
  • Organizer: IUPS Satellite Symposium on Endometrial Receptivity and Blastocyst.
  • Place of Presentation: Kyoto, Japan(招請講演)
  • Year and Date: 2009-07-25
• [Presentation] Animal model for reconstructed function human endometrium : Potential for drug testing and gene-target validation. (2009)
  • Author(s): Tetsuo Maruyama
  • Organizer: IUPS Satellite Symposium on Endometrial Receptivity and Blastocyst.
  • Place of Presentation: Kyoto, Japan
  • Year and Date: 2009-07-25
• [Presentation] ヒト子宮における再生と幹細胞. (2009)
  • Author(s): 丸山哲夫
  • Organizer: 第11回 RMB (生殖医学・生物学)研究会シンポジウム
  • Place of Presentation: 東京都新宿区
  • Year and Date: 2009-01-24
• [Presentation] Up-regulation of 5- and 15-lipoxygenases in endometriosis. (2009)
  • Author(s): Takashi Kajitani, Tetsuo Maruyama, Hironori Asada, Akiko Yamasaki, Hideyuki Oda, Sayaka Nishikawa, Hiroshi Uchida, Yasunori Yoshimura
  • Organizer: 25th European Society of Human Reproduction and Embryology(ESHRE).
  • Place of Presentation: Amsterdam, Netherlands
• [Presentation] UDP-glucose and its receptor P2RY14 as a novel innate immunity in the female reproductive tract. (2009)
  • Author(s): Toru Arase, Tetsuo Maruyama, Hiroshi Uchida, Takashi Kajitani, Sayaka Nishikawa, Hideyuki Oda, Maki Kagami, Hironori Asada, Yasunori Yoshimura
  • Organizer: 29th Ameican Society for Reproductive Immunology(ASRI)
  • Place of Presentation: Orlando, Florida
• [Presentation] The role of uterine smooth muscle stem cells, isolated based on cell surface markers, in myometrial remodeling in the pregnant uterus. (2009)
  • Author(s): Ono M, Maruyama T, Kajitani T, Uchida H, Oda H, Nishikawa S, Kagami M, Arase T, Nagashima T, Masuda H, Morikawa S, Mabuchi Y, Okano Y, Matsuzaki Y, Yoshimura Y
  • Organizer: 56th Society for Gynecologic Investigation
  • Place of Presentation: Glasgow, Scotland
• [Presentation] 表面抗原を用いたヒト子宮平滑筋幹細胞の新しい分離法の開発とその妊娠至急リモデリングにおける役割. (2009)
  • Author(s): 小野政徳, 丸山哲夫, 梶谷 宇, 内田 浩, 荒瀬 透, 小田英之, 西川明花, 各務真紀, 浅田弘法, 升田博隆, 岡野栄之, 松崎有未, 吉村泰典
  • Organizer: 第8回 日本再生医療学会
  • Place of Presentation: 東京都千代田区
• [Presentation] CE-TOFMSによる子宮内膜症患者腹水のメタボローム解析. (2009)
  • Author(s): 川田陽子, 浅田弘法, 杉本昌弘, 平山明山, 阿部しのぶ, 古谷正敬, 内田 浩, 浜谷敏生, 梶谷 宇, 丸山哲夫, 吉村泰典, 曽我朋義, 勝冨
  • Organizer: 第30回 日本エンドメトリオーシス学会
  • Place of Presentation: 宮城県仙台市
• [Presentation] 子宮内膜症組織におけるリポキシゲナーゼ経路関連遺伝子の発現解析 (2009)
  • Author(s): 梶谷 宇, 丸山哲夫, 浅田弘法, 内田 浩, 各務真紀, 小田英之, 西川明花, 山崎彰子, 吉村泰典
  • Organizer: 第30回 日本エンドメトリオーシス学会
  • Place of Presentation: 宮城県仙台市
• [Presentation] 腹腔鏡下ダグラス窩子宮内膜症病巣切除術の定型化と疼痛緩和効果に関する検討. (2009)
  • Author(s): 浅田弘法, 古谷正敬, 梶谷 宇, 内田 浩, 丸山哲夫, 吉村泰典, 升田博隆, 岸 郁子, 田島敏秀, 寺西貴英, 木挽貢慈
  • Organizer: 第30回 日本エンドメトリオーシス学会
  • Place of Presentation: 宮城県仙台市
• [Presentation] 子宮内膜症の発症に対して、EP300およびAHRR遺伝子多型がおよぼす影響. (2009)
  • Author(s): 辻 紘子, 浅田弘法, 浅井 哲, 古谷正敬, 内田 浩, 浜谷敏生, 丸山哲夫, 小崎健次郎, 柳橋達彦, 羽田智則, 安藤正明, 木挽貢慈, 吉村泰典
  • Organizer: 第30回 日本エンドメトリオーシス学会
  • Place of Presentation: 宮城県仙台市
• [Presentation] ヒト子宮内膜幹様細胞の同定. 分離とその幹細胞特性の機能解析. (2008)
  • Author(s): 升田博隆, 丸山哲夫, 小野政徳, 長島 隆, 梶谷 宇, 内田浩, 浅田弘法, 岡野栄之, 松崎有未, 吉村泰典
  • Organizer: 第13回 日本生殖内分泌学会
  • Place of Presentation: 大阪市北区
  • Year and Date: 2008-11-29
• [Presentation] ヒト子宮の分化・再生と幹細胞システム. (2008)
  • Author(s): 丸山哲夫
  • Organizer: 第16回 日本ステロイドホルモン学会
  • Place of Presentation: 福井県福井市
  • Year and Date: 2008-11-22
• [Presentation] Human dendometrial and myometrial stem cells. (2008)
  • Author(s): Maruyama T
  • Organizer: UCSF seminar
  • Place of Presentation: San Francisco, CA, USA
  • Year and Date: 2008-11-13
• [Presentation] Regeneration potential of stem cells systems in the human uterus. (2008)
  • Author(s): Maruyama T
  • Organizer: Instituto Universitario IVI seminar
  • Place of Presentation: Valencia, Sapin
  • Year and Date: 2008-07-11
• [Presentation] Regeneration potential of stem cell systems in the human female reproductive tract. (2008)
  • Author(s): Tetsuo Maruyama
  • Organizer: 1st World Congress on Reproductive Biology.
  • Place of Presentation: USA,Hawai(招請講演)
• [Presentation] Laparoscopic treatment of rectovaginal endometriosis(Japanese experience). (2008)
  • Author(s): Asada H, Furuya M, Uchida H, Maruyama T, Kobiki K, Kajitani T, Yoshimura Y
  • Organizer: 9th Asia Pasific Association for Gynecologic Endoscopy and Minimally Invasive Therapy (APAGE)
  • Place of Presentation: Daegu, Korea
• [Presentation] Psychosocial stress and mental health status of Japanese couples with a history of repeated pregnancy loss. (2008)
  • Author(s): Kagami M, Maruyama T, Kozumi T, Arase T, Uchida H, Yoshimura Y
  • Organizer: 64th Amerikan Society for Reproductive Medicine (ASRM)
  • Place of Presentation: San Francisco, CA, USA
• [Presentation] Regeneration potential of stem cell systems in the human female reproductive tract. (2008)
  • Author(s): Maruyama T
  • Organizer: 1st World Congress on Reproductive Biology (WCRB)
  • Place of Presentation: Kailua-Kona, Hawaii, USA
• [Presentation] Isolation and functional analysis of putative human endometria I stem/ progenitor cells. (2008)
  • Author(s): Masuda H, Maruyama T, 0no M, Kajitani T, Okano H, Yoshimura Y
  • Organizer: 24th European society of human reproduction and Embryology (ESHRE)
  • Place of Presentation: Barcelona, Spain
• [Presentation] 子宮平滑筋幹細胞の新しい分離法とその機能解析. (2008)
  • Author(s): 小野政徳, 丸山哲夫, 梶谷 宇, 内田 浩, 荒瀬 透, 小田英之, 西川明花, 長島 隆, 升田博隆, 馬渕 洋, 森川 暁, 岡野栄之, 松崎有未, 吉村泰典
  • Organizer: 第81回 日本内分泌学会学術総会
  • Place of Presentation: 青森県弘前市
• [Presentation] 染色体転座をもつ反復流産患者の生児獲得率に関する多施設共同研究 (2008)
  • Author(s): 杉浦真弓, 川口里恵, 丸山哲夫, 小郡伸晃, 杉 俊隆, 竹下俊行, 齋藤 滋
  • Organizer: 第53回 日本生殖医学会
  • Place of Presentation: 神戸市中央区
• [Presentation] 染色体転座をもつ反復流産患者の次回生児獲得率-多施設共同研究. (2008)
  • Author(s): 杉浦真弓, 青木耕治, 藤井知行, 藤田富雄, 川口里恵, 丸山哲夫, 小澤伸晃, 杉 俊隆, 竹下俊行, 齊藤 滋
  • Organizer: 第53回 日本人類遺伝学会
  • Place of Presentation: 神奈川県横浜市
• [Presentation] 腹腔鏡下ダグラス窩子宮内膜症病巣節叙述の疼痛緩和効果に関する検討. (2008)
  • Author(s): 浅田弘法, 古谷正敬, 高野光子, 内田 浩, 丸山哲夫, 青木大輔, 吉村泰典, 木挽貢慈
  • Organizer: 第48回 日本産科婦人科内視鏡学会
  • Place of Presentation: 横浜市西区
• [Presentation] 子宮内膜におけるP2RY14を介した新たな粘膜防御機構. (2008)
  • Author(s): 荒瀬 透, 丸山哲夫, 内田 浩, 梶谷 宇, 西川明花, 小田英之, 各務真紀, 浅田弘法, 吉村泰典
  • Organizer: 第23回 日本生殖免疫学会
  • Place of Presentation: 富山県富山市
• [Presentation] Chemial abortionの既往を有する反復流産患者の病院および妊娠転帰に関する検討. (2008)
  • Author(s): 西川明花, 丸山哲夫, 小田英之, 各務真紀, 荒瀬 透, 小野政徳, 長島 隆, 内田 浩, 吉村泰典
  • Organizer: 第53回 日本生殖医学会
  • Place of Presentation: 神戸市中央区
• [Book] 子宮腺筋症・子宮内膜症における最新の動向 (2011)
  • Author(s): 丸山哲夫
  • Publisher: 日本臨牀社
• [Patent(Industrial Property Rights)] 平滑筋幹細胞の単離方法 (2010)
  • Inventor(s): 丸山哲夫、小野政徳
  • Industrial Property Rights Holder: 学校法人慶應義塾
  • Industrial Property Number: 2010-507301
  • Acquisition Date: 2010-08-19
• [Patent(Industrial Property Rights)] 平滑筋幹細胞の単離方法 (2010)
  • Inventor(s): 丸山哲夫、小野政徳
  • Industrial Property Rights Holder: 学校法人慶應義塾
  • Acquisition Date: 2010-11-04
  • Overseas
• [Patent(Industrial Property Rights)] 平滑筋幹細胞の単離方法 (2010)
  • Inventor(s): 丸山哲夫、小野政徳
  • Industrial Property Rights Holder: 学校法人慶應義塾
  • Acquisition Date: 2010-10-11
  • Overseas
• [Patent(Industrial Property Rights)] 平滑筋幹細胞の単離方法 (2010)
  • Inventor(s): 丸山哲夫、小野政徳
  • Industrial Property Rights Holder: 学校法人慶應義塾
  • Acquisition Date: 2010-12-10
  • Overseas
• [Patent(Industrial Property Rights)] 平滑筋幹細胞の単離方法 (2010)
  • Inventor(s): 丸山哲夫, 小野政徳
  • Industrial Property Rights Holder: 学校法人慶應義塾
  • Industrial Property Number: 2010-507301
  • Filing Date: 2010-08-19
• [Patent(Industrial Property Rights)] 平滑筋幹細胞の単離方法 (2010)
  • Inventor(s): 丸山哲夫, 小野政徳
  • Industrial Property Rights Holder: 学校法人慶應義塾
  • Filing Date: 2010-11-04
  • Overseas
• [Patent(Industrial Property Rights)] 平滑筋幹細胞の単離方法 (2010)
  • Inventor(s): 丸山哲夫, 小野政徳
  • Industrial Property Rights Holder: 学校法人慶應義塾
  • Filing Date: 2010-10-11
  • Overseas
• [Patent(Industrial Property Rights)] 平滑筋幹細胞の単離方法 (2010)
  • Inventor(s): 丸山哲夫,小野政徳
  • Industrial Property Rights Holder: 学校法人慶應義塾
  • Filing Date: 2010-12-10
  • Overseas