Study on the mechanism of the age-related hearing loss and establishment of its preventive treatment
| Project/Area Number |
20390440
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Otorhinolaryngology
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| Research Institution | The University of Tokyo |
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Principal Investigator |
YAMASOBA TATSUYA The University of Tokyo, 医学部附属病院, 教授 (60251302)
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| Co-Investigator(Kenkyū-buntansha) |
KONDO Kenji 東京大学, 医学部附属病院, 講師 (40334370)
SAKAMOTO Takashi 東京大学, 医学部附属病院, 講師 (50323548)
鈴木 光也 東邦大学, 医学部, 准教授 (50302724)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥19,500,000 (Direct Cost: ¥15,000,000、Indirect Cost: ¥4,500,000)
Fiscal Year 2010: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2009: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2008: ¥11,440,000 (Direct Cost: ¥8,800,000、Indirect Cost: ¥2,640,000)
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| Keywords | 老化 / 蝸牛 / ミトコンドリア / アポトーシス / 難聴 / 酸化ストレス |
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| Research Abstract |
Deficiency of vitamin C accelerated presbyacusis (ARHL), whereas supplementation of vitamin C did not attenuate ARHL in C57BL/6 mice. The onset of ARHL was delayed when catalase was over-expressed in mitochondria in C57BL/6 mice. Such attenuation of ARHL was also observed when C57BL/6 mice were given alpha-lipoic acid, CoQ10, or NAC. Expression of Bak significantly decreased in the cochleae of the mice showing attenuation of ARHL. ARHL was significantly attenuated in Bak-deficient mice, but not in Bax-deficient mice. These findings suggest that chronic oxidative stress induced Bak-dependent apoptosis in the cochlear cells, resulting in the development of ARHL.
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Report
(4 results)
Research Products
(31 results)
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[Journal Article] Establishment of mice expressing EGFP in the placode-derived inner ear sensory cell lineage and FACS-array analysis focused on the regional specificity of the otocyst.2010
Author(s)
Fujimoto C, Ozeki H, Uchijima Y, Suzukawa K, Mitani A, Fukuhara S, Nishiyama K, Kurihara Y, Kondo K, Aburatani H, Kaga K, Yamasoba T
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Journal Title
J Comp Neurol
Volume: 518
Pages: 4702-4722
Related Report
Peer Reviewed
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[Journal Article] Age-related hearing loss in C57BL/6J mice is mediated by Bak-dependent mitochondrial apoptosis.2009
Author(s)
Someya S, Xu J, Kondo K, Ding D, Salvi RJ, Yamasoba T, Rabinovitch PS, Weindruch R, Leeuwenburgh C, Tanokura M, Prolla TA
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Journal Title
Proc Natl Acad Sci USA. 106
Pages: 19432-19437
Related Report
Peer Reviewed
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