| Budget Amount *help |
¥19,500,000 (Direct Cost: ¥15,000,000、Indirect Cost: ¥4,500,000)
Fiscal Year 2010: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2009: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2008: ¥11,440,000 (Direct Cost: ¥8,800,000、Indirect Cost: ¥2,640,000)
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| Research Abstract |
Deficiency of vitamin C accelerated presbyacusis (ARHL), whereas supplementation of vitamin C did not attenuate ARHL in C57BL/6 mice. The onset of ARHL was delayed when catalase was over-expressed in mitochondria in C57BL/6 mice. Such attenuation of ARHL was also observed when C57BL/6 mice were given alpha-lipoic acid, CoQ10, or NAC. Expression of Bak significantly decreased in the cochleae of the mice showing attenuation of ARHL. ARHL was significantly attenuated in Bak-deficient mice, but not in Bax-deficient mice. These findings suggest that chronic oxidative stress induced Bak-dependent apoptosis in the cochlear cells, resulting in the development of ARHL.
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