| Project/Area Number |
20390442
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Otorhinolaryngology
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| Research Institution | Ehime University |
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Principal Investigator |
GYO Kiyofumi Ehime University, 大学院・医学系研究科, 教授 (00108383)
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| Co-Investigator(Kenkyū-buntansha) |
HATA Ryuji 愛媛大学, 大学院・医学系研究科, 准教授 (90258153)
HATO Naohito 愛媛大学, 大学院・医学系研究科, 准教授 (60284410)
HAKUBA Nobuhiro 愛媛大学, 医学部附属病院, 講師 (70304623)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥18,330,000 (Direct Cost: ¥14,100,000、Indirect Cost: ¥4,230,000)
Fiscal Year 2010: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2009: ¥7,410,000 (Direct Cost: ¥5,700,000、Indirect Cost: ¥1,710,000)
Fiscal Year 2008: ¥8,190,000 (Direct Cost: ¥6,300,000、Indirect Cost: ¥1,890,000)
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| Keywords | 突発性難聴 / 虚血関連遺伝子 / 虚血関連タンパク / 内耳低温療法 / ischemic tolerance / 虚血再発の防御 / 虚血耐性 / 再発の防御 / 虚血関連蛋白 / 一過性内耳虚血 / スナネズミ / 遺伝子発現 / 虚血関連蛋白質 / 先行虚血 / 致死的虚血 / GPCR / microarray法 / 突発難聴 / 内耳虚血 / 有毛細胞障害 / 活性酸素 |
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| Research Abstract |
Pathology of transient cochlear ischemia as a cause of sudden deafness was investigated in gerbils. 1) Proteomic analysis showed that two genes, encoding GPCRs Class A and Peptide GPCRs, were dominantly expressed, suggesting needs for clinical study. 2) Cochlear damage was ameliorated by applying minor ischemia 2 days before major ischemia 3) Administration of AM-111, an apoptosis inhibitor, on the round window membrane was proved effective in decreasing damage of the cochlea.
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