Proteomic analysis of ischemic cochlear damage as a diagnostic tool of sudden sensorineural hearing loss
| Project/Area Number |
20390442
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (B)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Otorhinolaryngology
|
|---|
| Research Institution | Ehime University |
|---|
Principal Investigator |
GYO Kiyofumi Ehime University, 大学院・医学系研究科, 教授 (00108383)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
HATA Ryuji 愛媛大学, 大学院・医学系研究科, 准教授 (90258153)
HATO Naohito 愛媛大学, 大学院・医学系研究科, 准教授 (60284410)
HAKUBA Nobuhiro 愛媛大学, 医学部附属病院, 講師 (70304623)
|
|---|
| Project Period (FY) |
2008 – 2010
|
| Project Status |
Completed (Fiscal Year 2010)
|
| Budget Amount *help |
¥18,330,000 (Direct Cost: ¥14,100,000、Indirect Cost: ¥4,230,000)
Fiscal Year 2010: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2009: ¥7,410,000 (Direct Cost: ¥5,700,000、Indirect Cost: ¥1,710,000)
Fiscal Year 2008: ¥8,190,000 (Direct Cost: ¥6,300,000、Indirect Cost: ¥1,890,000)
|
|---|
| Keywords | 突発性難聴 / 虚血関連遺伝子 / 虚血関連タンパク / 内耳低温療法 / ischemic tolerance / 虚血再発の防御 / 虚血耐性 / 再発の防御 / 虚血関連蛋白 / 一過性内耳虚血 / スナネズミ / 遺伝子発現 / 虚血関連蛋白質 / 先行虚血 / 致死的虚血 / GPCR / microarray法 / 突発難聴 / 内耳虚血 / 有毛細胞障害 / 活性酸素 |
|---|
| Research Abstract |
Pathology of transient cochlear ischemia as a cause of sudden deafness was investigated in gerbils. 1) Proteomic analysis showed that two genes, encoding GPCRs Class A and Peptide GPCRs, were dominantly expressed, suggesting needs for clinical study. 2) Cochlear damage was ameliorated by applying minor ischemia 2 days before major ischemia 3) Administration of AM-111, an apoptosis inhibitor, on the round window membrane was proved effective in decreasing damage of the cochlea.
|
Report
(4 results)
Research Products
(47 results)
-
-
-
-
-
-
[Journal Article] Delayed neuronal cell death in brainstem after transient brainstem ischemia in gerbils2010
Author(s)
Cao, F., Hata, R., Zhu, P., Takeda, S., Yoshida, T., Hakuba, N., Sakanaka, M., Gyo, K
-
Journal Title
BMC Neurosci
Volume: 20(14)
Pages: 1-11
Related Report
Peer Reviewed
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
