| Project/Area Number |
20390443
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Otorhinolaryngology
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| Research Institution | Kagoshima University |
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Principal Investigator |
KURONO Yuichi Kagoshima University, 医歯学総合研究科, 教授 (80153427)
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| Co-Investigator(Kenkyū-buntansha) |
MATSUNE Shoji 鹿児島大学, 医歯学総合研究科, 准教授 (00253899)
YOSHIFUKU Kosuke 鹿児島大学, 医学部・歯学部附属病院, 講師 (70381168)
TANAKA Norimitsu 鹿児島大学, 医歯学総合研究科, 助教 (90404483)
OHORI Junichiro 鹿児島大学, 医歯学総合研究科, 助教 (90507162)
MAKISE Takao 鹿児島大学, 医学部・歯学部附属病院, 医員 (30585120)
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| Co-Investigator(Renkei-kenkyūsha) |
KWEON Mi-Na Mucosal Immunology Section, International Vaccine Institute, Seoul
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥19,500,000 (Direct Cost: ¥15,000,000、Indirect Cost: ¥4,500,000)
Fiscal Year 2010: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2009: ¥6,110,000 (Direct Cost: ¥4,700,000、Indirect Cost: ¥1,410,000)
Fiscal Year 2008: ¥8,970,000 (Direct Cost: ¥6,900,000、Indirect Cost: ¥2,070,000)
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| Keywords | 粘膜免疫 / 舌下免疫 / ワクチン / IgA / ホスホリルコリン / 上気道感染 / インフルエンザ菌 / 肺炎球菌 / 粘膜ワクチン / コレラキシン / 経鼻免疫 / IgE抗体 / 特異的IgA産生細胞 / IgA腎症 / 舌下ワクチン / コレラトキシン / PC特異的IgA産生細胞 / PAF受容体 / 口蓋扁桃 / 抗体産生細胞 |
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| Research Abstract |
In order to investigate the effectiveness and safety of sublingual vaccine for protecting upper respiratory infection, phosphorylcholine (PC) was sublingually administered to mice and mucosal immune responses were examined. The results showed that sublingual immunization with PC induced mucosal and systemic immune responses as strong as intranasal immunization and increased bacterial clearance from nose, indicating the immune-protective effectiveness of sublingual vaccine. Further, it was demonstrated that sublingual vaccine reduced type I allergic reaction.
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