| Budget Amount *help |
¥15,470,000 (Direct Cost: ¥11,900,000、Indirect Cost: ¥3,570,000)
Fiscal Year 2010: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2009: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2008: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
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| Research Abstract |
Homozygote RAMP-2 knockout(KO) mice are fatal before delivery, but heterozygote RAMP-2 KO mice show largely normal development except for systemic edema. We found these mice have marked retinal edema. Diabetic retinal edema is a leading cause of legal blindness. There has been no animal model for retinal edema.(RAMP)-2 knockout mice are new and the only existing animal model of retinal edema. Using this model, we reported that insufficient formation of tight junction and disruption of Bruch' s membrane are potential causes of breakdown of blood-retinal barrier.
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