New therapeutic approach for glaucoma via drug-mediated bleb regulation

• Project/Area Number: 20390449
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Ophthalmology
• Research Institution: Kumamoto University
• Principal Investigator: TANIHARA Hidenobu Kumamoto University, 大学院・生命科学研究部, 教授 (60217148)
• Co-Investigator(Kenkyū-buntansha): INATANI Masaru 熊本大学, 医学部附属病院, 講師 (40335245) ; KAWAJI Takahiro 熊本大学, 医学部附属病院, 講師 (30423677)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥19,240,000 (Direct Cost: ¥14,800,000、Indirect Cost: ¥4,440,000); Fiscal Year 2010: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000); Fiscal Year 2009: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000); Fiscal Year 2008: ¥6,760,000 (Direct Cost: ¥5,200,000、Indirect Cost: ¥1,560,000)
• Keywords: 眼薬理学 / 創傷治癒

Research Abstract

We identified risk factors for surgical failure of trabeculectomy, a major surgery for glaucoma patients. In open-glaucoma patients, previous cataract surgery is a significant risk factor for the surgical failure while previous cataract surgery and granulomatous uveitis-type are risk factors in uveitic glaucoma patients. An anti-VEGF drug, bevacizumab, reduces surgical complications, and improves the short-term surgical success of trabeculectomy.

Research Products

• [Journal Article] on behalf of the Japanese Steroid-Induced Glaucoma Multicenter Study Group. Success rates of trabeculotomy for steroid-induced glaucoma : a comparative, multicenter, retrospective, cohort study. (2011)
  • Author(s): Iwao K, Inatani M, Tanihara H
  • Journal Title: American Journal of Ophthalmology in press
• [Journal Article] ROCK inhibitors : a novel approach to glaucoma therapy. (2011)
  • Author(s): Inoue T, Tanihara H.
  • Journal Title: Progress in Retinal and Eye Research in press
• [Journal Article] Combined intravitreal bevacizumab and trabeculectomy with mitomycin C versus trabeculectomy with mitomycin C alone for neovascular glaucoma. (2011)
  • Author(s): Takihara Y, Inatani M, Kawaji T, Fukushima M, Iwao K, Iwao M, Tanihara H.
  • Journal Title: Journal of Glaucoma 20(3) Pages: 196-201
• [Journal Article] Trabeculectomy with mitomycin C for open-angle glaucoma in phakic eyes vs pseudophakic eyes after phacoemulsification. (2011)
  • Author(s): Takihara Y, et al.
  • Journal Title: Archives of Ophthalmology Volume: 129 Pages: 152-157
  • Peer Reviewed
• [Journal Article] ROCK inhibitors : a novel approach to glaucoma therapy. (2011)
  • Author(s): Inoue T, Tanihara H
  • Journal Title: Progress in Retinal and Eye Research Volume: (印刷中)
  • Peer Reviewed
• [Journal Article] Combined intravitreal bevacizumab and trabeculectomy with mitomycin C versus trabeculectomy with mitomycin C alone for neovascular glaucoma. (2011)
  • Author(s): Takihara Y, et al.
  • Journal Title: Journal of Glaucoma Volume: 120 Pages: 196-201
  • Peer Reviewed
• [Journal Article] Trabeculectomy with mitomycin C for neovascular glaucoma : Prognostic factors for surgical failure. (2009)
  • Author(s): Takihara Y, Inatani M, Fukushima M, Iwao K, Iwao M, Tanihara H.
  • Journal Title: American Journal of Ophthalmology 147(5) Pages: 912-918
• [Journal Article] Restricted post-trabeculectomy bleb formation by conjunctival scarring. (2009)
  • Author(s): Iwao K, Inatani M, Ogata-Iwao M, Takihara Y, Tanihara H.
  • Journal Title: Graefe's Archive for Clinical and Experimental Ophthalmology 247(8) Pages: 1095-1101
• [Journal Article] Trabeculectomy with mitomycin C for neovascular glaucoma : Prognostic factors for surgical failure (2009)
  • Author(s): Takihara Y, Inatani M, Fukushima M, Iwao K, Iwao M, Tanihara H.
  • Journal Title: American Journal of Ophthalmology 147 Pages: 912-918
  • Peer Reviewed
• [Journal Article] Restricted post-trabeculectomy bleb formation by conjunctival scarring (2009)
  • Author(s): Iwao K, Inatani M, Ogata-Iwao M, Takihara Y, Tanihara H.
  • Journal Title: Graefe's Archive for Clinical and Experimental Ophthalmology 247 Pages: 1095-1101
  • Peer Reviewed
• [Journal Article] Trabeculectomy with mitomycin C for neovascular glaucoma : Prognostic factors for surgical failure. (2009)
  • Author(s): Takihara Y
  • Journal Title: American Journal of Ophthalmology (印刷中)
  • Peer Reviewed
• [Journal Article] ROCK Inhibitor Clinical Study Group. Intraocular pressure-lowering effects and safety of topical administration of a selective ROCK inhibitor (2008)
  • Author(s): Tanihara H, Inatani M, Honjo M, Tokushige H, Azuma J, Araie M
  • Journal Title: SNJ-1656, in normal volunteers. Archives of Ophthalmology 126 Pages: 309-315
• [Journal Article] Combined intravitreal bevacizumab and trabeculectomy with mitomycin C versus trabeculectomy with mitomycin C alone for neovascular glaucoma
  • Author(s): Takihara Y, Inatani M, Kawaji T, Fukushima M, Iwao K, Iwao M, Tanihara H.
  • Journal Title: Journal of Glaucoma (印刷中)
  • Peer Reviewed
• [Journal Article] Restricted post-trabeculectomy bleb formation by conjunctival scarring.
  • Author(s): Iwao K
  • Journal Title: Graefe's Archive for Clinical and Experimental Ophthalmology (印刷中)
  • Peer Reviewed
• [Presentation] 線維柱帯切除術の白内障手術が眼圧経過に与える影響の検討 (2010)
  • Author(s): 笠岡奈々子、井上俊洋、川口淳、瀧原祐史、瀬戸孝彦、稲谷大、岩尾美奈子、布田龍佑、谷原秀信
  • Organizer: 第64回日本臨床眼科学会
  • Place of Presentation: 兵庫県神戸市国際会議場
• [Presentation] 緑内障房水サンプルに対するサイトカインの多項目同時解析 (2010)
  • Author(s): 井上俊洋、稲谷大、亀田隆範、笠岡奈々子、井上みゆき、藤本智和、吉村長久、谷原秀信
  • Organizer: 第64回日本臨床眼科学会
  • Place of Presentation: 兵庫県神戸市国際会議場
• [Presentation] 開放隅角緑内障に対するトラベクレクトミーの術後早期前房内炎症の前向き調査 (2010)
  • Author(s): 岩尾美奈子、稲谷大、瀧原祐史、岩尾圭一郎、井上俊洋、笠岡奈々子、谷原秀信
  • Organizer: 第21回日本緑内障学会
  • Place of Presentation: 福岡市アクロス福岡
• [Presentation] 外眼手術による結膜瘢痕のある症例への線維柱帯切除術の術後成績 (2010)
  • Author(s): 小島みほ、稲谷大、井上俊洋、谷原秀信
  • Organizer: 第80回九州眼科学会
  • Place of Presentation: 佐賀市ホテルマリターレ創世
• [Presentation] Intraocular pressure elevation after intraocular lens suture fixation for ectopia of crystalline or intraocular lenses. (2010)
  • Author(s): Eiki D, Inatani M, Inoue T, Kasaoka Y, Takihara Y, Tanihara H
  • Organizer: The Annual Meeting of the Association for Research in Vision and Ophthalmology (ARVO) Convention Center
  • Place of Presentation: Fort Lauderdale, Florida, USA
• [Presentation] Trabeculectomy with mitomyci C for open-angle glaucoma in phakic eyes vs. pseudophakic eyes after phacoemulsification. (2010)
  • Author(s): Takihara Y, Inatani M, Seto T, Iwao K, Iwao M, Inoue T, Kasaoka N, Murakami A, Futa R, Tanihara H
  • Organizer: The Annual Meeting of the Association for Research in Vision and Ophthalmology (ARVO) Convention Center
  • Place of Presentation: Fort Lauderdale, Florida, USA
• [Presentation] Risk factors for secondary glaucoma after vitrectomy for proliferative diabetic retinopathy. (2010)
  • Author(s): Tanaka A, Inatani M, Inoue T, Kasaoka Y, Takihara Y, Ito Y, Fukushima M, Tanihara H
  • Organizer: The Annual Meeting of the Association for Research in Vision and Ophthalmology (ARVO) Convention Center
  • Place of Presentation: Fort Lauderdale, Florida, USA
• [Presentation] The long-term outcome and pronostic factors for trabeculecotmy in uveitis-related glaucoma eyes : retrospective cohort study at 2 clinical centers. (2010)
  • Author(s): Iwao K, Inatani M, Seto T, Takihra Y, Ogata-Iwao M, Okinami S, Tanihara H
  • Organizer: The Annual Meeting of the Association for Research in Vision and Ophthalmology (ARVO) Convention Center
  • Place of Presentation: Fort Lauderdale, Florida, USA
• [Presentation] トラベクレクトミー術後に濾過胞再建術を施行した8眼についての術後検討 (2010)
  • Author(s): 岩尾美奈子、稲谷大、岩尾圭一郎、瀧原祐史、瀬戸孝彦、谷原秀信
  • Organizer: 第19回日本緑内障学会
  • Place of Presentation: 大阪市 国際会議場
• [Presentation] 落屑緑内障と原発開放隅角緑内障に対する初回トラベクレクトミー術後成績の比較 (2010)
  • Author(s): 瀬戸孝彦、稲谷大、瀧原祐史、岩尾圭一郎、岩尾美奈子、村上晶、谷原秀信
  • Organizer: 第19回日本緑内障学会
  • Place of Presentation: 大阪市 国際会議場
• [Presentation] Potential new drugs acting on the conventional outflow system. (2010)
  • Author(s): Inatani M
  • Organizer: A Joint Meeting of APAO/AAO
  • Place of Presentation: 国家会議中心 中華人民共和国北京
• [Presentation] 緑内障手術既往眼へのトラベクレクトミーの術後予後因子の検討 (2009)
  • Author(s): 笠岡奈々子、井上俊洋、稲谷大、瀧原祐史、岩尾美奈子、谷原秀信
  • Organizer: 第20回日本緑内障学会
  • Place of Presentation: 沖縄県宜野湾市
• [Presentation] 硝子体切除術既往のあるトラベクレクトミー症例の予後因子の検討 (2009)
  • Author(s): 井上俊洋、稲谷大、瀧原祐史、笠岡奈々子、岩尾美奈子、谷原秀信
  • Organizer: 第20回日本緑内障学会
  • Place of Presentation: 沖縄県宜野湾市コンベンションセンター
• [Presentation] 血管新生緑内障に対する線維柱帯切除術予後不良群への術後ベバシズマブ硝子体内複数回投与の検討 (2009)
  • Author(s): 瀧原祐史、稲谷大、井上俊洋、岩尾圭一郎、岩尾美奈子、笠岡奈々子、谷原秀信
  • Organizer: 第20回日本緑内障学会
  • Place of Presentation: 沖縄県宜野湾市コンベンションセンター
• [Presentation] 開放隅角緑内障に対するトラベクレクトミー単独手術と白内障同時手術との前向き比較研究 (2009)
  • Author(s): 岩尾美奈子、稲谷大、瀧原祐史、岩尾圭一郎、井上俊洋、笠岡奈々子、谷原秀信
  • Organizer: 第20回日本緑内障学会
  • Place of Presentation: 沖縄県宜野湾市コンベンションセンター
• [Presentation] Trabeculectomy with mitomycin C for neovascular glaucoma : Prognostic factors for surgical failure. (2009)
  • Author(s): Inatani M, Takihara H, Fukushima M, Iwao K, Iwao M, Tanihara H
  • Organizer: Convention Center
  • Place of Presentation: The World Glaucoma Congress Boston, MA
• [Presentation] 円蓋部基底結膜切開トラベクレクトミーを6時方向に施行した5眼の術後検討 (2009)
  • Author(s): 大平さおり、稲谷大、井上俊洋、谷原秀信
  • Organizer: 第79回九州眼科学会
  • Place of Presentation: 福岡市アクロス福岡
• [Presentation] Steroid-induced Glaucoma Multicenter Study Group. Prognostic factors and long-term outcome of trabeculotomy for steroid-induced glaucoma : Multicenter retrospective case-control study. (2009)
  • Author(s): 岩尾圭一郎, 稲谷大
  • Organizer: The Annual Meeting of the Association for Research in Vision and Ophthalmology (ARVO) Convention Center
  • Place of Presentation: Fort Lauderdale, Florida, USA, 2009 May3-7.
• [Presentation] Combined intravitreal bevacizumab and trabeculectomy with mitomycin C versus trabeculectomy with mitomycin C for neovascular glaucoma. (2009)
  • Author(s): Takihara Y, Inatani M, Kawaji T, Fukushima M, Iwao K, Iwao M, Tanihara H
  • Organizer: The Annual Meeting of the Association for Research in Vision and Ophthalmology (ARVO) Convention Center
  • Place of Presentation: Fort Lauderdale, Florida, USA
• [Presentation] ステロイド緑内障多施設調査グループ ステロイド緑内障に対するトラベクロトミーの多施設調査 (2009)
  • Author(s): 尾圭一郎、稲谷大
  • Organizer: 第113回日本眼科学会総会
  • Place of Presentation: 東京都 国際フォーラム
• [Presentation] 血管新生緑内障に対する Bevacizumab 併用線維柱帯切除術の効果 (2009)
  • Author(s): 瀧原祐史, 稲谷大, 川路隆博, 福島美紀子, 岩尾圭一郎, 岩尾奈子, 谷原秀信
  • Organizer: 第113回日本眼科学会総会
  • Place of Presentation: 東京都、東京国際フォーラム
• [Presentation] ぶどう膜炎に伴う続発緑内障と原発開放隅角緑内障への初回トラベクレクトミーの予後比較とリスクファクター (2008)
  • Author(s): 岩尾圭一郎、稲谷大、瀬戸孝彦、瀧原祐史、岩尾美奈子、谷原秀信
  • Organizer: 第19回日本緑内障学会
  • Place of Presentation: 大阪市 国際会議場
• [Presentation] 有水晶体眼と偽水晶体眼間のトラベクレクトミー術後成績の比較:開放隅角緑内障での予後因子の検討 (2008)
  • Author(s): 瀧原祐史、稲谷大、瀬戸孝彦、岩尾圭一郎、岩尾美奈子、谷原秀信
  • Organizer: 第19回日本緑内障学会
  • Place of Presentation: 大阪市 国際会議場
• [Presentation] 血管新生緑内障に対する濾過手術 眼科手術と生体反応 (2008)
  • Author(s): 稲谷 大
  • Organizer: 第112回日本眼科学会総会
  • Place of Presentation: 神奈川県横浜市西区みなみらいパシフィコ横浜
• [Book] 虹彩ルベオーシス対するBevacizumab (2010)
  • Author(s): 稲谷大
  • Total Pages: 1
  • Publisher: メディカル葵出版
• [Book] あたらしい眼科 (2009)
  • Author(s): 稲谷 大
  • Publisher: メディカル葵出版(印刷中)