| Budget Amount *help |
¥19,630,000 (Direct Cost: ¥15,100,000、Indirect Cost: ¥4,530,000)
Fiscal Year 2010: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2009: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2008: ¥11,310,000 (Direct Cost: ¥8,700,000、Indirect Cost: ¥2,610,000)
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| Research Abstract |
In the embryos affected by all trans retinoic acid (ATRA) only, all of them had anorectalmalformations (ARM). In the embryos affected by ATRA and LE135, however, about 40% of the embryos had normal rectum and anus but had short tail. Therefore, these findings indicate that RA receptor antagonist prevents disturbance of the cell signaling pathway between the epithelium and the mesenchyme layers because RA receptor antagonist inhibits RA receptor from forming heterodimers with RX receptors.
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