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Can we detect the invasive keloid fibroblasts for the effective treatment?

Research Project

Project/Area Number 20390454
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Plastic surgery
Research InstitutionHokkaido University

Principal Investigator

HAYASHI Toshihiko (2009-2010)  Hokkaido University, 北海道大学病院, 助教 (00432146)

佐々木 了 (2008)  Hokkaido University, 大学院・医学研究科, 非常勤講師 (40301907)

Co-Investigator(Kenkyū-buntansha) YAMAMOTO Yuhei  北海道大学, 大学院・医学研究科, 教授 (70271674)
FURUKAWA Hiroshi  北海道大学, 大学院・医学研究科, 講師 (00399924)
OYAMA Akihiko  北海道大学, 大学病院, 講師 (70374486)
FUNAYAMA Emi  北海道大学, 大学院・医学研究科, 助教 (10533630)
SEKIDO Mitsuru  筑波大学, 大学院・人間総合科学研究科, 教授 (40372255)
TSUTSUMIDA Arata  国立がん研究センター中央病院, 皮膚腫瘍科, 医長 (00374489)
SAITO Akira  北海道大学, 大学院・医学研究科, 非常勤講師 (70507574)
林 利彦  北海道大学, 病院, 医員 (00432146)
Project Period (FY) 2008 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥19,630,000 (Direct Cost: ¥15,100,000、Indirect Cost: ¥4,530,000)
Fiscal Year 2010: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2009: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2008: ¥12,220,000 (Direct Cost: ¥9,400,000、Indirect Cost: ¥2,820,000)
Keywordsケロイド / ケロイド線維芽細胞 / 免疫細胞 / 共培養 / Tリンパ球
Research Abstract

In a keloid lesion, T lymphocytes are found around activated and invasive keloid fibroblasts whose levels of type 1 collagen production, transforming growth factor-beta expression and α-SMA expression are very high. So we co-cultured keloid fibroblasts with T lymphocytes to establish the keloid in vitro model. But the levels of type 1 collagen and transforming growth factor-beta of the keloid fibroblasts co-cultured with T lymphocytes tended to rather decrease. Some subset of T lymphocytes might suppress keloid fibroblasts.

Report

(4 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (3 results)

All 2011 2010

All Presentation (3 results)

  • [Presentation] Tリンパ球とケロイド線維芽細胞の相互作についての検証2011

    • Author(s)
      村尾尚規,林利彦,齋藤亮,舟山恵美,小山明彦,古川洋志,山本有平
    • Organizer
      第81回日本形成外科学会北海道地方会
    • Place of Presentation
      札幌市
    • Year and Date
      2011-02-19
    • Related Report
      2010 Final Research Report
  • [Presentation] Tリンパ球とケロイド線維芽細胞の相互作用についての検証2011

    • Author(s)
      村尾尚規, 林利彦
    • Organizer
      第81回日本形成外科学会北海道地方会
    • Place of Presentation
      札幌市
    • Year and Date
      2011-02-19
    • Related Report
      2010 Annual Research Report
  • [Presentation] ケロイド線維芽細胞とTリンパ球共培養モデル構築の試み2010

    • Author(s)
      村尾尚規,林利彦,小山明彦,舟山恵美,山本有平
    • Organizer
      第19回日本形成外科学会基礎学術集会
    • Place of Presentation
      横浜市
    • Year and Date
      2010-09-16
    • Related Report
      2010 Annual Research Report 2010 Final Research Report

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Published: 2008-04-01   Modified: 2016-04-21  

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