| Project/Area Number |
20390454
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Plastic surgery
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| Research Institution | Hokkaido University |
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Principal Investigator |
HAYASHI Toshihiko (2009-2010) Hokkaido University, 北海道大学病院, 助教 (00432146)
佐々木 了 (2008) Hokkaido University, 大学院・医学研究科, 非常勤講師 (40301907)
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| Co-Investigator(Kenkyū-buntansha) |
YAMAMOTO Yuhei 北海道大学, 大学院・医学研究科, 教授 (70271674)
FURUKAWA Hiroshi 北海道大学, 大学院・医学研究科, 講師 (00399924)
OYAMA Akihiko 北海道大学, 大学病院, 講師 (70374486)
FUNAYAMA Emi 北海道大学, 大学院・医学研究科, 助教 (10533630)
SEKIDO Mitsuru 筑波大学, 大学院・人間総合科学研究科, 教授 (40372255)
TSUTSUMIDA Arata 国立がん研究センター中央病院, 皮膚腫瘍科, 医長 (00374489)
SAITO Akira 北海道大学, 大学院・医学研究科, 非常勤講師 (70507574)
林 利彦 北海道大学, 病院, 医員 (00432146)
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| Project Period (FY) |
2008 – 2010
|
| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥19,630,000 (Direct Cost: ¥15,100,000、Indirect Cost: ¥4,530,000)
Fiscal Year 2010: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2009: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2008: ¥12,220,000 (Direct Cost: ¥9,400,000、Indirect Cost: ¥2,820,000)
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| Keywords | ケロイド / ケロイド線維芽細胞 / 免疫細胞 / 共培養 / Tリンパ球 |
|---|
| Research Abstract |
In a keloid lesion, T lymphocytes are found around activated and invasive keloid fibroblasts whose levels of type 1 collagen production, transforming growth factor-beta expression and α-SMA expression are very high. So we co-cultured keloid fibroblasts with T lymphocytes to establish the keloid in vitro model. But the levels of type 1 collagen and transforming growth factor-beta of the keloid fibroblasts co-cultured with T lymphocytes tended to rather decrease. Some subset of T lymphocytes might suppress keloid fibroblasts.
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