| Project/Area Number |
20390461
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Emergency medicine
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| Research Institution | Showa University |
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Principal Investigator |
SHIODA Seiji Showa University, 医学部, 教授 (80102375)
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| Co-Investigator(Kenkyū-buntansha) |
OHTAKI Hirokazu 昭和大学, 医学部, 助教 (20349062)
NAKANACHI Tomoya 昭和大学, 遺伝子組換え実験室, 助教 (30433840)
荒田 悟 昭和大学, 遺伝子組換え実験室, 准教授 (20159502)
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| Co-Investigator(Renkei-kenkyūsha) |
ARATA Satoru 昭和大学, 遺伝子組換え実験室, 准教授 (20159502)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
|
| Budget Amount *help |
¥19,370,000 (Direct Cost: ¥14,900,000、Indirect Cost: ¥4,470,000)
Fiscal Year 2010: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Fiscal Year 2009: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2008: ¥12,740,000 (Direct Cost: ¥9,800,000、Indirect Cost: ¥2,940,000)
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| Keywords | PACAP / PAC1-R / IL-6 / 神経細胞死 / 神経再生 / PAC-1R |
|---|
| Research Abstract |
We have studied to clarify the molecular basis for PACAP on protection of delayed neuronal cell death after brain ischemia in mice and to make a translational study for humans. I n addition, we have also studied the molecular mechanism of PACAP on stimulating differentiation from neural stem cells into neurons and/or glial cells. Moreover, we developed a new drug delivery system (DDS) of PACAP by use of intranasal infusion to protect delayed neuronal cell death after brain ischemia. The present study will have a strong impact for protection of brain ischemia and it will open a new avenue to use of PACAP and its related peptides for clinical use for patients who will be suffered from neurodegeneration after brain ischemia with a new developed DDS.
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