| Project/Area Number |
20390463
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (B)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Morphological basic dentistry
|
|---|
| Research Institution | Tokyo Medical and Dental University |
|---|
Principal Investigator |
NAKAHAMA Kenichi Tokyo Medical and Dental University, 大学院・医歯学総合研究科, 准教授 (60281515)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
MORITA Ikuo 東京医科歯科大学, 教授 (60100129)
YOKOYAMA Chieko 東京医科歯科大学, COE特任教授 (90200914)
SATO Takahiro 東京医科歯科大学, 寄付講座職員 (20397003)
ICHINOSE Shizuko 東京医科歯科大学, 助教 (60015146)
市野瀬 志津子 東京医科歯科大学, 先端研究支援センター, 助教 (60014156)
|
|---|
| Co-Investigator(Renkei-kenkyūsha) |
AKIYAMA Masako 東京医科歯科大学, 特任助教 (30436646)
|
|---|
| Project Period (FY) |
2008 – 2010
|
| Project Status |
Completed (Fiscal Year 2010)
|
| Budget Amount *help |
¥19,110,000 (Direct Cost: ¥14,700,000、Indirect Cost: ¥4,410,000)
Fiscal Year 2010: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2009: ¥7,540,000 (Direct Cost: ¥5,800,000、Indirect Cost: ¥1,740,000)
Fiscal Year 2008: ¥6,760,000 (Direct Cost: ¥5,200,000、Indirect Cost: ¥1,560,000)
|
|---|
| Keywords | 骨芽細胞 / 骨細胞 / 破骨細胞 / コネキシン43 / cAMP / ギャップジンクション / ギャップジャンクション / RAW細胞 / 破骨細胞前駆細胞 / 破骨細胞分化 / 接着分子 / CD11b |
|---|
| Research Abstract |
We aimed to find the roles of cell communication in bone remodeling. We found an important role of cell communication between osteoclast precursors in osteoclastogenesis via adhesion molecule. Next, we showed the possibility that the gap junctional intercellular communication between osteoblasts and osteocytes controlled osteoclastogenesis via cyclic AMP signaling.
|
