Elucidation of functional significance of caveola in periodontal mechanoreceptor
| Project/Area Number |
20390464
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Morphological basic dentistry
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| Research Institution | Niigata University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
IZUMI Kenji 新潟大学, 医歯学系, 准教授 (80242436)
INOUE Kayoko 新潟大学, 医歯学系, 特任准教授 (90303130)
KAWANO Yoshiro 新潟大学, 医歯学系, 助教 (60303129)
SUZUKI Akiko 新潟大学, 医歯学系, 特任助教 (70509538)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥18,980,000 (Direct Cost: ¥14,600,000、Indirect Cost: ¥4,380,000)
Fiscal Year 2010: ¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
Fiscal Year 2009: ¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
Fiscal Year 2008: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
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| Keywords | カベオラ / カベオリン / 機械受容 / 歯根膜ルフィニ神経終末 / カルシウムイオン / 歯根膜 / ルフィニ神経終末 / 末梢神経再生 / 軸索-シュワン細胞相互作用 / 終末シュワン細胞 / GDNF / 機械受容器 |
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| Research Abstract |
The Ruffini endings, a primary mechanoreceptor in the periodontal ligament, well-develop caveolae in their cell membrane. The present study examined the functional significance of caveolae in the periodontal Ruffini endings. The caveolae were consisted of caveolin-1 with diverse functions. A unique immuno-localization pattern of caveolin-1 and Ca^<2+>-pump suggested caveolae is involved in the quick elimination of intracellular Ca^<2+> which influx into the axon terminals in mechanotransduction.
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Report
(4 results)
Research Products
(22 results)
