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Functional analysis for molecular interaction through a new member of the immunoglobulin superfamily in tooth germ development

Research Project

Project/Area Number 20390466
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Morphological basic dentistry
Research InstitutionKyushu University

Principal Investigator

SAKAI Hidetaka  九州大学, 歯学研究院, 教授 (80136499)

Co-Investigator(Kenkyū-buntansha) KOBAYASHI Ieyoshi  九州大学, 歯学研究院, 准教授 (40243951)
KIYOSHIMA Tamotsu  九州大学, 歯学研究院, 講師 (20264054)
NAGATA Kengo  九州大学, 歯学研究院, 助教授 (90189134)
Project Period (FY) 2008 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥19,240,000 (Direct Cost: ¥14,800,000、Indirect Cost: ¥4,440,000)
Fiscal Year 2011: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Fiscal Year 2010: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2009: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2008: ¥9,750,000 (Direct Cost: ¥7,500,000、Indirect Cost: ¥2,250,000)
Keywords口腔病理学 / 歯の発生・再生 / 歯原性幹細胞 / 器官培養 / 歯胚 / 発生・再生 / cDNAサブトラクション / in situ hybridization / 免疫組織化学 / アンチセンス法 / in situ hybhdization
Research Abstract

Protogenin(Prtg) has been identified as a gene that is highly expressed in the mouse mandible at embryonic day 10. 5(E10. 5). Prtg is a new member of the deleted in colorectal carcinoma(DCC) family. This study examined the functional implications of Prtg in the developing tooth germ of the mouse lower first molar. Ptrg is preferentially expressed in the early stage of organogenesis. Prtg was widely expressed in the mesenchymal and oral epithelial cells in the E10. 5 mandible. The expression of Prtg after E12. 0 was markedly reduced in the mandible, and was restricted to the area where the tooth bud was likely to be formed. An antisense inhibition assay for Prtg in cultured E10. 5 mandibles showed a significant growth inhibition in the tooth germ. Bmp-4 expression had significantly been decreased in the mouse E10. 5 mandible at 24 hr after Prtg inhibition. These results indicated that the Prtg might be related to the initial morphogenesis of the tooth germ in the mouse lower first molar. In addition, in situ expression of Ifrg15, L21 and ATPase6 genes suggest that these genes participate in the initiation and the development of the tooth germ as well as those of the other craniofacial organs. Other examination results also demonstrated that Tβ4 is involved in the early stage of tooth germ development by regulation of the odontogenesis-related gene expression.

Report

(6 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report   Self-evaluation Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (62 results)

All 2011 2010 2009 2008 Other

All Journal Article (23 results) (of which Peer Reviewed: 20 results) Presentation (37 results) Remarks (2 results)

  • [Journal Article] 左側上顎に発生した石灰化嚢胞性歯原性腫瘍の1例2011

    • Author(s)
      藤原弘明、小林家吉、清島保、永田健吾、和田裕子、大隈由紀子、塩塚真帆、木原槇子、坂井英隆
    • Journal Title

      診断病理

      Volume: 28巻1号 Pages: 117-121

    • NAID

      10029411792

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] In situ expression of the mitochondrial ATPase6 gene in the developing tooth germ of the mouse lower first molar2011

    • Author(s)
      Honda JY, Kobayashi I, Kiyoshima T, Nagata K, Wada H, Ookuma Y, Fujiwara H, Shiotsuka M, Takahashi I, Sakai H
    • Journal Title

      Journal Molecular Histology

      Volume: Vol.42 Pages: 83-90

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Antimicrobial and antifungal effects of tissue conditioners containing a2011

    • Author(s)
      Uchimaru M, Sakai T, Moroi R, Shiota S, Shibata Y, Deguchi M, Sakai H, Yamashita Y and Yoshihiro Terada Y
    • Journal Title

      photocatalyst Dent Mater J

      Volume: Vol.30 No.5 Pages: 691-699

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Shobuike T The transcription factor FBI-1/OCZF/LRF is expressed in osteoclasts and regulates RANKL-induced osteoclast formation in vitro and in vivo2011

    • Author(s)
      Kukita A, Kukita T, Nagata K, Teramachi J, Li YJ, Yoshida H, Miyamoto H, Gay S, Pessler F
    • Journal Title

      Arthritis Rheum

      Volume: Vol.63 No.9 Pages: 2744-2754

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] In situ expression of the mitochondrial ATPase6 gene in the developing tooth germ of the mouse lower first molar2011

    • Author(s)
      J.Honda, H.Sakai, et al
    • Journal Title

      Journal of Molecular Histology

      Volume: 42 Issue: 1 Pages: 83-90

    • DOI

      10.1007/s10735-010-9309-z

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Antimicrobial and antifungal effects of tissue conditioners containing a photocatalyst2011

    • Author(s)
      M.Uchimaru, H.Sakai, et al
    • Journal Title

      Dental Materials Journal

      Volume: 30 Issue: 5 Pages: 691-699

    • DOI

      10.4012/dmj.2010-203

    • NAID

      10029480766

    • ISSN
      0287-4547, 1881-1361
    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 左側上顎に発生した石灰化嚢胞性歯原性腫瘍の1例2011

    • Author(s)
      藤原弘明、坂井英隆, 他
    • Journal Title

      診断病理

      Volume: 28 Pages: 117-121

    • NAID

      10029411792

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The transcription factor FBI-1/OCZF/LRF is expressed in osteoclasts and regulates RANKL-induced osteoclast formation in vitro and in vivo2011

    • Author(s)
      A.Kukita, K.Nagata, et al
    • Journal Title

      Arthritis & Rheumatism

      Volume: 63 Issue: 9 Pages: 2744-2754

    • DOI

      10.1002/art.30455

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] In situ expression of the mitochondrial ATPase6 gene in the developing tooth germ of the mouse lower first molar.2011

    • Author(s)
      Jun-ya Honda, Ieyoshi Kobayashi, Tamotsu Kiyoshima, Kengo Nagata, Hiroko Wada, Yukiko Ookuma, Hiroaki Fujiwara, Maho Shiotsuka, Ichiro Takahashi, Hidetaka Sakai
    • Journal Title

      Journal of Molecular Histology 42

      Pages: 83-90

    • Related Report
      2010 Self-evaluation Report
  • [Journal Article] In situ expression of the mitochondrial ATPase6 gene in the developing tooth germ of the mouse lower first molar.2011

    • Author(s)
      Jun-ya Honda, et al
    • Journal Title

      Journal of Molecular Histology

      Volume: 42 Pages: 83-90

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Protogenin, a new member of the immunoglobulin superfamily2010

    • Author(s)
      Takahashi KF, Kobayashi I, Xie Kiyoshima M, Yamaza T, H, Fujiwara H, Ookuma Y, Nagata K, Wada H, Sakai T, Terada Y, and Sakai H
    • Journal Title

      BMC Dev Biol

      Volume: Vol.10 No.115

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] In situ expression of 15 kDa interferon alpha responsive gene in the developing tooth germ of the mouse lower first molar2010

    • Author(s)
      Akhter M, Kobayashi I, Kiyoshima T, Nagata K, Wada H, Ookuma Y, Fujiwara H, Honda JY and Sakai H
    • Journal Title

      J Mol Histol

      Volume: Vol.41 No.4-5 Pages: 185-191

    • NAID

      120005227146

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] In situ expression of 15kDa interferon alpha responsive gene in the developing tooth germ of the mouse lower first molar.2010

    • Author(s)
      Merina Akhter, Ieyoshi Kobayashi, Tamotsu Kiyoshima, Kengo Nagata, Hiroko Wada, Yukiko Ookuma, Hiroaki Fujiwara, Jyun-ya Honda, Hidetaka Sakai
    • Journal Title

      Journal of Molecular Histology 41

      Pages: 185-191

    • NAID

      120005227146

    • Related Report
      2010 Self-evaluation Report
  • [Journal Article] Protogenin, a new member of the immunoglobulin superfamily, is implicated in the development of the mouse lower first molar.2010

    • Author(s)
      Keiko F Takahashi, Tamotsu Kiyoshima, Ieyoshi Kobayashi, Ming Xie, Haruyoshi Yamaza, Hiroaki Fujiwara, Yukiko Ookuma, Kengo Nagata, Hiroko Wada, Takako Sakai, Yoshihiro Terada, Hidetaka Sakai
    • Journal Title

      BMC Developmental Biology 10

      Pages: 115-115

    • Related Report
      2010 Self-evaluation Report
  • [Journal Article] In situ expression of 15kDa interferon alpha responsive gene in the developing tooth germ of the mouse lower first molar.2010

    • Author(s)
      Merina Akhter, et al
    • Journal Title

      Journal of Molecular Histology

      Volume: 41 Pages: 185-191

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Protogenin, a new member of the immunoglobulin superfamily, is implicated in the development of the mouse lower first molar.2010

    • Author(s)
      Keiko F Takahashi
    • Journal Title

      BMC Developmental Biology

      Volume: 10 Pages: 115-115

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] In situ expression of ribosomal protein L21 in developing tooth germ of the mouse lower first molar2009

    • Author(s)
      Xie M, Kobayashi I, Kiyoshima T, Nagata K, Ookuma Y, Fujiwara H and Sakai H
    • Journal Title

      J Mol Histol

      Volume: Vol.40 No.5-6 Pages: 361-367

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] In situ expression of ribosomal protein L21 in developing tooth germ of the mouse lower first molar.2009

    • Author(s)
      Ming Xie, et al.
    • Journal Title

      Journal of Molecular Histology 31

      Pages: 361-367

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A possible suppressive role of galectin-3 in upregulated osteoclasto-genesis accompanying adjuvant-induced arthritis in rats.2009

    • Author(s)
      Li, Yin-Ji, et al.
    • Journal Title

      LABORATORY INVESTIGATION 89(1)

      Pages: 26-37

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Self-cleaning Ability of a Denture Base Material containing a Photocatalys2008

    • Author(s)
      Cheng Y, Sakai T, Moroi R, Nakagawa M, Sakai H, Ogata T and Terada Y
    • Journal Title

      Dent mater J

      Volume: Vol.27 No.2 Pages: 179-186

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Glycolytic enzyme Pgk1 is strongly expressed in the developing tooth germ of the mouse2008

    • Author(s)
      Honda JY, Kobayashi I, Kiyoshima T, Yamaza H, Xie M, Takahashi K, Enoki N, Nagata K, Nakashima A and Sakai H
    • Journal Title

      lower first molar Histol Histopathol

      Volume: Vol.23 No.4 Pages: 423-432

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Glycolytic enzyme Pgk1 is strongly expressed in the developing tooth germ of the mouse lower first molar.2008

    • Author(s)
      Jun-ya Honda, et al.
    • Journal Title

      Histology and Histopathology 23

      Pages: 423-432

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Self-cleaning Ability of a Denture Base Material containing a Photocatalys.2008

    • Author(s)
      Yali CHENG, et al.
    • Journal Title

      Dental material Journal 27

      Pages: 179-186

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Presentation] 歯胚形成過程におけるThymosinβ-10の役割~Thymosinβ-4との比較検討~2011

    • Author(s)
      和田裕子、坂井英隆, 他
    • Organizer
      第100回日本病理学会総会
    • Place of Presentation
      横浜
    • Year and Date
      2011-04-28
    • Related Report
      2011 Annual Research Report
  • [Presentation] Thymosin beta 4のノックッダウンによる歯原性細胞の変化について2011

    • Author(s)
      小林家吉、坂井英隆, 他
    • Organizer
      第100回日本病理学会総会
    • Place of Presentation
      横浜
    • Year and Date
      2011-04-28
    • Related Report
      2011 Annual Research Report
  • [Presentation] Thymosin beta 4のノックダウンによる歯原性細胞の変化についてケ2011

    • Author(s)
      小林家吉、清島保、永田健吾、和田裕子、藤原弘明、塩塚真帆、坂井英隆
    • Organizer
      第100回日本病理学会総会
    • Place of Presentation
      横浜
    • Related Report
      2011 Final Research Report
  • [Presentation] 歯胚形成過程におけるThymosin b-10の役割~Thymosin b-4との比較検討~2011

    • Author(s)
      和田裕子、塩塚真帆、清島保、小林家吉、永田健吾、藤原弘明、坂井英隆
    • Organizer
      第100回日本病理学会総会
    • Place of Presentation
      横浜
    • Related Report
      2011 Final Research Report
  • [Presentation] 癌治療用アポトーシス誘導ベクターの作成と導入の試み2011

    • Author(s)
      古庄克宏、和田裕子、清島保、小林家吉、永田健吾、藤原弘明、塩塚真帆、坂井英隆
    • Organizer
      第53回歯科基礎医学会学術大会ならびに総会
    • Place of Presentation
      岐阜
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] 遺伝子Xの導入による歯原性上皮細胞誘導の試み2011

    • Author(s)
      藤原弘明、坂井英隆
    • Organizer
      第88回九大病理研究会
    • Place of Presentation
      福岡
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] Sakai Expression pattern and possible function of thymosin beta-10 in developing tooth germ compared with2011

    • Author(s)
      Y. Ookuma, I. Kobayashi, T. Kiyoshima, K. Nagata, H. Wada, K. Nonaka and H. Sakai
    • Organizer
      thymosin beta-4 The 6th International Joint Symposium on"Dental and Craniofacial Morphogenesis and Tissue Regeneration"and"Oral Health Science"
    • Place of Presentation
      福岡
    • Related Report
      2011 Final Research Report
  • [Presentation] Functional implication of thymosin beta-4 in the morphogenesis of the tooth germ via the regulation of odontogenic gene2011

    • Author(s)
      Y. Ookuma, I. Kobayashi, T. Kiyoshima, K. Nagata, H. Wada, K. Nonaka and H. Sakai
    • Organizer
      expressions The 6th International Joint Symposium on"Dental and Craniofacial Morphogenesis and Tissue Regeneration"and"Oral Health Science"
    • Place of Presentation
      福岡
    • Related Report
      2011 Final Research Report
  • [Presentation] Inter leukin-22-induced STAT3 signal transduction in oral squamous cell carcinoma.2010

    • Author(s)
      Lutfun Naher, 他3名
    • Organizer
      第5回"口腔組織の再生・再建医療研究"シンポジウム
    • Place of Presentation
      福岡
    • Year and Date
      2010-02-05
    • Related Report
      2009 Annual Research Report
  • [Presentation] マウス歯胚形成過程におけるThymosin beta 10とThymosin beta 4との発現様式の比較検討2010

    • Author(s)
      和田裕子、清島保、小林家吉、塩塚真帆、永田健吾、大隈由紀子、藤原弘明、高橋一郎、坂井英隆
    • Organizer
      第52回歯科基礎医学会学術大会
    • Place of Presentation
      東京
    • Related Report
      2011 Final Research Report
  • [Presentation] 歯胚発生期から咬合完成期におけるthymosin b-10発現様式と機能について-thymosin b-4との比較検討-2010

    • Author(s)
      塩塚真帆、和田裕子、坂井英隆
    • Organizer
      第87回九大病理研究会
    • Place of Presentation
      福岡
    • Related Report
      2011 Final Research Report
  • [Presentation] Functional implication of Thymosin beta 4 in the tooth development2010

    • Author(s)
      Y. Ookuma, I. Kobayashi, T. Kiyoshima, K. Nagata, H. Fujiwara, H. Yamaza, K. Nonaka and H. Sakai
    • Organizer
      the 88th IADR General Session
    • Place of Presentation
      バルセロナ
    • Related Report
      2011 Final Research Report
  • [Presentation] Functional implication of Thymosin beta 4 in the tooth development2010

    • Author(s)
      Y.OOKUMA, I.OBAYASHI, T.KIYOSHIMA, K.NAGATA, H.FUJIWARA, H.YAMAZA, K.NONAKA, H.SAKAI
    • Organizer
      The 88th General Session & Exhibition of the IADR)
    • Place of Presentation
      Barcelona, Spain
    • Related Report
      2010 Self-evaluation Report
  • [Presentation] マウス歯胚形成過程におけるThymosinb10とThymosinb4との発現様式の比較検討2010

    • Author(s)
      和田裕子、清島保、小林家吉、塩塚真帆、永田健吾、大隈由紀子、藤原弘明、高橋一郎、坂井英隆
    • Organizer
      第52回歯科基礎医学会学術大会ならびに総会
    • Place of Presentation
      東京
    • Related Report
      2010 Self-evaluation Report
  • [Presentation] IL-22によるヒト口腔扁平上皮癌の細胞形質に対する影響2010

    • Author(s)
      清島保, 他
    • Organizer
      第99回日本病理学会総会
    • Place of Presentation
      東京
    • Related Report
      2010 Annual Research Report
  • [Presentation] ヒト口腔扁平上皮癌細胞のヒストン脱アセチル化酵素阻害剤によるアポトーシス誘導2010

    • Author(s)
      永田健吾, 他
    • Organizer
      第99回日本病理学会総会
    • Place of Presentation
      東京
    • Related Report
      2010 Annual Research Report
  • [Presentation] マウス歯胚形成過程におけるThymosinb10とThymosinb4との発現様式の比較検討2010

    • Author(s)
      和田裕子, 他
    • Organizer
      第52回歯科基礎医学会
    • Place of Presentation
      東京
    • Related Report
      2010 Annual Research Report
  • [Presentation] ヒストン脱アセチル化酵素阻害剤suberoylanilide hydroxamic acidによるヒト口腔扁平上皮癌細胞のアポトーシス誘導2010

    • Author(s)
      永田健吾, 他
    • Organizer
      第52回歯科基礎医学会
    • Place of Presentation
      東京
    • Related Report
      2010 Annual Research Report
  • [Presentation] Functional implication of Thymosin beta 4 in the tooth development2010

    • Author(s)
      Y.OOKUMA, et al.
    • Organizer
      The 88th General Session & Exhibition of the IADR
    • Place of Presentation
      Barcelona, Spain
    • Related Report
      2010 Annual Research Report
  • [Presentation] 歯胚の形熊形成におけるThymosin beta 4の機能的役割について2009

    • Author(s)
      大隈由紀子, 他2名
    • Organizer
      第86回九大病理研究会
    • Place of Presentation
      福岡
    • Year and Date
      2009-12-12
    • Related Report
      2009 Annual Research Report
  • [Presentation] 歯胚形成過程におけるRp121およびIfrg15の発現様式について2009

    • Author(s)
      小林家吉, 他5名
    • Organizer
      第51回歯科基礎医学会学術大会
    • Place of Presentation
      新潟
    • Year and Date
      2009-09-10
    • Related Report
      2009 Annual Research Report
  • [Presentation] Tumor of the Mandible.2009

    • Author(s)
      Yoshinao Oda, 他5名
    • Organizer
      Closed Meeting of the 36^<th> International Skeletal Society
    • Place of Presentation
      Washington DC, USA
    • Year and Date
      2009-08-31
    • Related Report
      2009 Annual Research Report
  • [Presentation] IgG4関蓮硬化性疾患における生検小唾液腺の病理組織学的所見2009

    • Author(s)
      清島保, 他3名
    • Organizer
      第20回日本臨床口腔病理学会総会
    • Place of Presentation
      札幌
    • Year and Date
      2009-07-30
    • Related Report
      2009 Annual Research Report
  • [Presentation] Functional implication of thymosin beta 4 on the morphogenesis of tooth germ in the mouse lower first molar2009

    • Author(s)
      Y. Ookuma, I. Kobayashi, T. Kiyoshima, K. Nagata, K. Nonaka and H. Sakai
    • Organizer
      The 4th International Joint Symposium on"Dental and Craniofacial Morphogenesis and Tissue Regeneration"and"Oral Health Science"
    • Place of Presentation
      福岡
    • Related Report
      2011 Final Research Report
  • [Presentation] ヒト扁平上皮癌におけるIL-22シグナル経路2009

    • Author(s)
      清島 保、小林家吉、坂井英隆
    • Organizer
      第98回日本病理学会総会
    • Place of Presentation
      京都
    • Related Report
      2011 Final Research Report 2009 Annual Research Report
  • [Presentation] 歯胚形成過程におけるRpl21およびIfrg15の発現様式について2009

    • Author(s)
      小林家吉、清島保、永田健吾、大隈由紀子、藤原弘明、坂井英隆
    • Organizer
      第51回歯科基礎医学会学術大会ならびに総会
    • Place of Presentation
      新潟
    • Related Report
      2011 Final Research Report
  • [Presentation] 歯胚の形態形成におけるThymosin beta 4の機能的役割について2009

    • Author(s)
      大隈由紀子、小林家吉、坂井英隆
    • Organizer
      第86回九大病理研究会
    • Place of Presentation
      福岡
    • Related Report
      2011 Final Research Report
  • [Presentation] Possible functions of Protogenin in the tooth2009

    • Author(s)
      K. Fukiwake, T. Kiyoshima, I. Kobayashi, K. Nagata and H. Sakai
    • Organizer
      development the 86^<th> IADR/AADR
    • Place of Presentation
      トロント
    • Related Report
      2011 Final Research Report
  • [Presentation] 歯胚発生過程における膜蛋白Protogeninの発現と歯胚発育への関与2008

    • Author(s)
      清島保、小林家吉、坂井英隆
    • Organizer
      第97回日本病理学会総会
    • Place of Presentation
      金沢
    • Related Report
      2011 Final Research Report
  • [Presentation] 歯原性細胞におけるThymosin b4を介したMatrix metalloproteinaseの発現調節について2008

    • Author(s)
      大隈由紀子、小林家吉、清島保、吹譯景子、永田健吾、藤原弘明、野中和明、坂井英隆
    • Organizer
      第50回歯科基礎医学会
    • Place of Presentation
      東京
    • Related Report
      2011 Final Research Report
  • [Presentation] 久木田敏夫葉酸拮抗剤による破骨細胞形成阻害はアデノシンにより解除される2008

    • Author(s)
      寺町順平、久木田明子、李銀姫、永田健吾
    • Organizer
      第50回歯科基礎医学会
    • Place of Presentation
      東京
    • Related Report
      2011 Final Research Report
  • [Presentation] 歯原性細胞のMatrix metalloproteinase発現調節機構におけるThymosinβ4の効果について2008

    • Author(s)
      小林家吉、大隈由紀子、清島 保、永田健吾、吹譯景子、藤原弘明、Naher Lutfan、野中和明、坂井英隆
    • Organizer
      第49回日本組織細胞化学総会・学術集会
    • Place of Presentation
      長崎
    • Related Report
      2011 Final Research Report
  • [Presentation] 歯胚発生過程における膜蛋白Protogeninの発現と歯胚発育への関与2008

    • Author(s)
      清島保, 他2名
    • Organizer
      第97回日本病理学会総会
    • Place of Presentation
      石川県金沢市
    • Related Report
      2008 Annual Research Report
  • [Presentation] 歯胚形成過程におけるNucleolinおよびThymosin beta4 の関与について2008

    • Author(s)
      小林家吉, 他2名
    • Organizer
      第97回日本病理学会総会
    • Place of Presentation
      石川県金沢市
    • Related Report
      2008 Annual Research Report
  • [Presentation] Possible functions of Protogenin in the tooth development2008

    • Author(s)
      K. Fukiwake, et al.
    • Organizer
      the 86^<th> IADR/AADR
    • Place of Presentation
      Toronto (Canada)
    • Related Report
      2008 Annual Research Report
  • [Presentation] 歯原性細胞におけるThymosin β4を介したMatrix metalloproteinaseの発現調節について2008

    • Author(s)
      大隈由紀子, 他7名
    • Organizer
      第50回歯科基礎医学会
    • Place of Presentation
      東京都
    • Related Report
      2008 Annual Research Report
  • [Presentation] 歯原性細胞のMatrix metalloproteinase発現調節機構におけるThymosin β4の効果について2008

    • Author(s)
      小林家吉, 他8名
    • Organizer
      第49回日本組織細胞化学総会・学術集会
    • Place of Presentation
      長崎県長崎市
    • Related Report
      2008 Annual Research Report
  • [Remarks]

    • URL

      http://www.dent.kyushu-u.ac.jp/

    • Related Report
      2011 Annual Research Report
  • [Remarks]

    • URL

      http://www.dent.kyushu-u.ac.jp/

    • Related Report
      2010 Annual Research Report

URL: 

Published: 2008-04-01   Modified: 2016-04-21  

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