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The study on stressful lesion suppression mechanism of the BDNF derived from a salivary gland

Research Project

Project/Area Number 20390467
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Morphological basic dentistry
Research InstitutionKanagawa Dental College

Principal Investigator

TSUKINOKI Keiichi  Kanagawa Dental College, 歯学部, 教授 (00298233)

Co-Investigator(Kenkyū-buntansha) SAITO Ichiro  鶴見大学, 歯学部, 教授 (60147634)
Co-Investigator(Renkei-kenkyūsha) SARUTA Juri  神奈川歯科大学, 歯学部, 講師 (30454151)
Project Period (FY) 2008 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥19,630,000 (Direct Cost: ¥15,100,000、Indirect Cost: ¥4,530,000)
Fiscal Year 2010: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2009: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2008: ¥12,220,000 (Direct Cost: ¥9,400,000、Indirect Cost: ¥2,820,000)
Keywords唾液腺 / BDNF / マウス / ストレス性病変 / 血漿BDNF / Tgマウス / PSPプロモーター / 血漿 / 水深拘束ストレス / TrkB / p75 / トランスジェニックマウス / ストレス / 胃潰瘍
Research Abstract

We developed the Tg mouse with high BDNF expression in the salivary gland. We manufactured the construct composed of PSP parotid gland-specific for the promoter, mouse BDNF and HA tag. Because the BDNF produced with a salivary gland is composed as the protein which an HA tag was added to as for the characteristic of this Tg mouse, it is the epoch-making Tg mouse which it is possible for intrinsic BDNF and distinction, and can prove in vivo behavior of the salivary gland production BDNF. This Tg mouse had a defense tendency for stress load.

Report

(4 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (54 results)

All 2011 2010 2009 2008 2006 Other

All Journal Article (22 results) (of which Peer Reviewed: 10 results) Presentation (27 results) Book (3 results) Remarks (2 results)

  • [Journal Article] The role of neurotrophins related to stress in saliva and salivary glands.2010

    • Author(s)
      Saruta J, Sato S, Tsukinoki K
    • Journal Title

      Histol Histopathol. 25(10)

      Pages: 1317-30

    • Related Report
      2010 Final Research Report
  • [Journal Article] Salivary glands as the source of plasma BDNF in stressed rats engaged in biting behavior.2010

    • Author(s)
      Saruta J, Kondo Y, Sato C, Shiiki N, Tsukinoki K, Sato S
    • Journal Title

      Stress 13(3)

      Pages: 238-247

    • Related Report
      2010 Final Research Report
  • [Journal Article] Chronic stress affects the expression of BDNF in rat submandibular glands.2010

    • Author(s)
      Saruta J, Lee T, Shirasu M, Takahashi T, Sato C, Sato S, Tsukinoki K
    • Journal Title

      Stress 13(1)

      Pages: 53-60

    • Related Report
      2010 Final Research Report
  • [Journal Article] Expression and role of the BDNF receptor-TrkB in rat adrenal gland under acute immobilization stress.2010

    • Author(s)
      Kondo Y, Saruta J, Tsukinoki K
    • Journal Title

      Acta Histochem Cytochem

    • NAID

      130000395318

    • Related Report
      2010 Final Research Report
  • [Journal Article] The role on neurotrophins related to stress in saliva and salivary glands.2010

    • Author(s)
      Saruta J, Sato S, Tsukinoki K.
    • Journal Title

      Histol Histopathol.

      Volume: 25 Pages: 1317-1330

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Salivary glands as the source of plasma brain-derived neurotrophic factor in stressed rats engaged in biting behavior.2010

    • Author(s)
      Saruta J, Kondo Y, Sato C, Shiiki N, Tsukinoki K, Sato S.
    • Journal Title

      Stress.

      Volume: 13 Pages: 238-247

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Chronic stress affects the expression of brain-derived neurotrophic factor in rat salivary glands.2010

    • Author(s)
      Saruta J, Lee T, Shirasu M, Takahashi T, Sato C, Tsukinoki K.
    • Journal Title

      Stress.

      Volume: 13 Pages: 53-60

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Chronic stress affects the expression of BDNF in rat submandibular glands2010

    • Author(s)
      Juri S, 他
    • Journal Title

      Stress 13

      Pages: 53-60

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Salivary glands as the source of plasma BDNF in stressed rats engaged in biting behavior2010

    • Author(s)
      Juri S, 他
    • Journal Title

      Stress 13

      Pages: 238-247

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Restoration of BRAK/CXCL14 gene expression by gefitinib is associated with antitumor efficacy of the drug in head and neck squamous cell carcinoma.2009

    • Author(s)
      Ozawa S, Kate Y, Ito S, Komori R, Shiiki N, Tsukinoki K
    • Journal Title

      Cancer Science. 100(11)

      Pages: 2202-9

    • NAID

      10027197383

    • Related Report
      2010 Final Research Report
  • [Journal Article] Cervical sympathectomy causes alveolar bone loss in an experimental rat model.2009

    • Author(s)
      Kim Y, Hamada N, Takahashi Y, Sasaguri K, Tsukinoki K, Onozuka M, Sato S
    • Journal Title

      J Periodontal Res. 44(6)

      Pages: 695-703

    • Related Report
      2010 Final Research Report
  • [Journal Article] Restoration of BRAK/CXCL14 gene expression by gefitinib is associated with antitumor efficacy of the drug in head and neck squamous cell carcinoma.2009

    • Author(s)
      Ozawa S, 他
    • Journal Title

      Cancer Sci 100

      Pages: 2202-2209

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Detection of salivary peroxidase specific mRNA expression in healthy parotid gland by in situ hybridization2009

    • Author(s)
      Jun O, 他
    • Journal Title

      The Bulletin of Kanagawa Dental College 37

      Pages: 89-93

    • Related Report
      2009 Annual Research Report
  • [Journal Article] Role of certain saliva proteins as a biomarker under conditions of stress2009

    • Author(s)
      Juri S, 他
    • Journal Title

      The Bulletin of Kanagawa Dental College 37

      Pages: 65-68

    • Related Report
      2009 Annual Research Report
  • [Journal Article] Cervical sympathectomy causes alveolar bone loss in an experimental rat model.2009

    • Author(s)
      Kim Y, 他
    • Journal Title

      J Periodontal Res. 44

      Pages: 695-703

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Peripheral keratocystic odontogenic tumor : a case report2009

    • Author(s)
      Jinbu Y, 他
    • Journal Title

      Oral Surgery 2

      Pages: 95-98

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Allowing animals to bite reverses the effects of immobilization stress on hippocampal neurotrophin expression.2008

    • Author(s)
      Lee T, Saruta J, Sasaguri K, Sato S, Tsukinoki K
    • Journal Title

      Brain Res 1195

      Pages: 43-49

    • Related Report
      2010 Final Research Report
  • [Journal Article] Effect of bruxism-like activity on the salivary Chromogranin A as a stress marker.2008

    • Author(s)
      Okamura M, Yoshida A, Saruta J, Tsukinoki K, Sasaguri K, Sato S
    • Journal Title

      Stomatologie 105

      Pages: 33-39

    • Related Report
      2010 Final Research Report
  • [Journal Article] p63(TP63) elicits strong trans-activation of the MFG-E8/lactadherin/BA46 gene through interactions between the TA and DeltaN isoforms.2008

    • Author(s)
      Okuyama T, Kurata S, Tomimori Y, Fukunishi N, Sato S, Osada M, Tsukinoki K
    • Journal Title

      Oncogene, 10 27(3)

      Pages: 308-317

    • Related Report
      2010 Final Research Report
  • [Journal Article] Loss of 14-3-3 sigma protein expression and presence of human papillomavirus type 16 E6 in oral squamous cell carcinoma.2008

    • Author(s)
      Bhawal UK, Sugiyama M, Nomura Y, Kuniyasu H, Tsukinoki K
    • Journal Title

      Arch Otolaryngol Head and Neck Surg 134(10)

      Pages: 1055-1059

    • Related Report
      2010 Final Research Report
  • [Journal Article] Loss of 14-3-3 sigma protein expression and presence of humanpapillomavirus type 16 E6 in oral squamous cell carcinoma.2008

    • Author(s)
      Bhawal UK, et al
    • Journal Title

      Arch Otolaryngol Head Neck Surg. 134(10)

      Pages: 1055-9

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Allowing animals to bite reverses the effects of immobilization stresson hippocampal neurotrophin expression.2008

    • Author(s)
      Lee T, et al
    • Journal Title

      Brain Res 2l ; ll95

      Pages: 43-9

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Presentation] 唾液腺産生物質の血中移行による全身への影響についての検討2011

    • Author(s)
      佐藤允俊,東雅啓,近藤裕介,猿田樹理,槻木恵一
    • Organizer
      第134回神奈川歯科大学学会例会
    • Place of Presentation
      横須賀
    • Year and Date
      2011-01-13
    • Related Report
      2010 Final Research Report
  • [Presentation] 唾液腺BDNFの病態生理学的意義についての研究第9報:In vivoにおけるストレス応答に対するTrkBの役割について2011

    • Author(s)
      近藤裕介,猿田樹理,佐藤允俊,東雅啓,吉野文彦,小林杏,吉田彩佳,李昌一,槻木恵一
    • Organizer
      第134回神奈川歯科大学学会例会
    • Place of Presentation
      横須賀
    • Year and Date
      2011-01-13
    • Related Report
      2010 Final Research Report
  • [Presentation] 唾液腺BDNFの病態生理学的意義についての研究第8報:ラット副腎におけるBDNFとTrkBの役割2010

    • Author(s)
      近藤裕介,東雅啓,椎木直人,佐藤允俊,猿田樹理,槻木恵一
    • Organizer
      第133回神奈川歯科大学学会例会
    • Place of Presentation
      横須賀
    • Year and Date
      2010-10-14
    • Related Report
      2010 Final Research Report
  • [Presentation] 唾液腺BDNF の病態生理学的意義についての研究・第8報:ラット副腎におけるBDNFとTrkBの役割2010

    • Author(s)
      近藤裕介,猿田樹理,佐藤允俊,東雅啓,槻木恵一
    • Organizer
      第133回神奈川歯科大学学会例会
    • Place of Presentation
      横須賀
    • Year and Date
      2010-10-14
    • Related Report
      2010 Final Research Report
  • [Presentation] 唾液腺から考える全身の健康-唾液腺健康医学の創生に向けて-2010

    • Author(s)
      槻木恵一
    • Organizer
      第52回日本歯科基礎医学会総会サテライトシンポジウム
    • Place of Presentation
      タワーホール船堀展示ホール1
    • Year and Date
      2010-09-20
    • Related Report
      2010 Annual Research Report
  • [Presentation] 咀嚼器官活性化によるストレス緩和についての研究2010

    • Author(s)
      佐藤允俊, 猿田樹理, 笹栗健一, 槻木恵一, 佐藤貞雄
    • Organizer
      第131回 神奈川歯科大学学会例会
    • Place of Presentation
      横須賀
    • Year and Date
      2010-01-14
    • Related Report
      2009 Annual Research Report
  • [Presentation] Basic studies about development of metabolic syndrome diagnostic method to using saliva.2010

    • Author(s)
      Saruta J, Sato C, Kondo Y, Shiiki N, Sasaguri K, Tsukinoki K, Sato S
    • Organizer
      Iaaid-Asia 3rd
    • Place of Presentation
      Kyoto, Japan
    • Related Report
      2010 Final Research Report
  • [Presentation] In vivo experimental model of human gingival mucosa using immunodeficient mice.2010

    • Author(s)
      Kamata Y, Saruta J, Onozawa N, Kondo Y, Tsukinoki K, Yamaguchi S, Tamura T
    • Organizer
      96th Annual Meeting American Academy of Periodontology in collaboration with the Japanese Society of Periodontology.
    • Place of Presentation
      Honolulu, HI, America
    • Related Report
      2010 Final Research Report
  • [Presentation] 噛むことはラット唾液腺においてストレスで誘導されたBDNFを増加させる2010

    • Author(s)
      猿田樹理,近藤裕介,佐藤貞雄,槻木恵一
    • Organizer
      第21回日本臨床口腔病理学会総会・学術集会
    • Place of Presentation
      大阪
    • Related Report
      2010 Final Research Report
  • [Presentation] 噛むことは拘束ストレスによる海馬のニュートロフィン発現減少を抑制する2010

    • Author(s)
      猿田樹理,近藤裕介,椎木直人,佐藤貞雄,槻木恵一
    • Organizer
      第64回日本口腔科学会学術集会
    • Place of Presentation
      札幌
    • Related Report
      2010 Final Research Report
  • [Presentation] ストレス性病変におけるBDNFの役割2010

    • Author(s)
      近藤裕介,猿田樹理,李昌一,佐藤貞雄,槻木恵一
    • Organizer
      第64回日本口腔科学会学術集会
    • Place of Presentation
      札幌
    • Related Report
      2010 Final Research Report
  • [Presentation] Basic studies about development of metabolic syndrome diagnostic method to using saliva.2010

    • Author(s)
      Saruta J, 他
    • Organizer
      Iaaid-Asia 3^<rd>
    • Place of Presentation
      Kyoto
    • Related Report
      2009 Annual Research Report
  • [Presentation] 唾液腺BDNFの病態生理学的意義についての研究-第7報:ストレス性病変におけるBDNFの役割2009

    • Author(s)
      近藤裕介,猿田樹理,佐藤貞雄,槻木恵一
    • Organizer
      第130回神奈川歯科大学学会例会
    • Place of Presentation
      横須賀
    • Year and Date
      2009-10-15
    • Related Report
      2010 Final Research Report
  • [Presentation] 唾液腺BDNFの病態生理学的意義についての研究-第7報:ストレス性病変におけるBDNFの役割2009

    • Author(s)
      近藤裕介, 猿田樹理, 佐藤貞雄, 槻木恵一
    • Organizer
      第130回 神奈川歯科大学学会例会
    • Place of Presentation
      横須賀
    • Year and Date
      2009-10-15
    • Related Report
      2009 Annual Research Report
  • [Presentation] 急性拘束ストレスモデルはラット副腎のTrkB発現に影響を与える2009

    • Author(s)
      猿田樹理,佐藤允俊,近藤裕介,笹栗健一,槻木恵一,佐藤貞雄
    • Organizer
      第68回日本矯正歯科学会大会
    • Place of Presentation
      福岡
    • Related Report
      2010 Final Research Report 2009 Annual Research Report
  • [Presentation] ヒト唾液腺におけるBDNF発現と局在2009

    • Author(s)
      猿田樹理,近藤裕介,笹栗健一,槻木恵一,佐藤貞雄
    • Organizer
      第51回日本歯科基礎医学会総会・学術集会
    • Place of Presentation
      新潟
    • Related Report
      2010 Final Research Report 2009 Annual Research Report
  • [Presentation] 慢性拘束ストレスはラット唾液腺において神経栄養因子の発現に影響を与える2009

    • Author(s)
      猿田樹理,近藤裕介,槻木恵一
    • Organizer
      第20回日本臨床口腔病理学会総会・学術集会
    • Place of Presentation
      札幌
    • Related Report
      2010 Final Research Report 2009 Annual Research Report
  • [Presentation] 刺激性線維種における発生由来についての免疫組織学的検討2009

    • Author(s)
      槻木恵一,佐藤一芳,窪田展久,三好代志子,猿田樹理,近藤裕介
    • Organizer
      第20回日本臨床口腔病理学会総会・学術集会
    • Place of Presentation
      札幌
    • Related Report
      2010 Final Research Report 2009 Annual Research Report
  • [Presentation] ヒト唾液腺および唾液におけるBDNF発現2009

    • Author(s)
      近藤裕介,猿田樹理,佐藤貞雄,槻木恵一
    • Organizer
      第20回日本臨床口腔病理学会総会・学術集会
    • Place of Presentation
      札幌
    • Related Report
      2010 Final Research Report 2009 Annual Research Report
  • [Presentation] 噛むことはラット唾液腺においてストレスで誘導されたBDNFを増加させる2009

    • Author(s)
      猿田樹理,近藤裕介,佐藤貞雄,槻木恵一
    • Organizer
      第63回日本口腔科学会学術集会
    • Place of Presentation
      浜松
    • Related Report
      2010 Final Research Report 2009 Annual Research Report
  • [Presentation] ヒト唾液腺におけるBDNF 発現と局在2009

    • Author(s)
      近藤裕介,猿田樹理,椎木直人,佐藤貞雄,槻木恵一
    • Organizer
      第63回日本口腔科学会学術集会
    • Place of Presentation
      浜松
    • Related Report
      2010 Final Research Report
  • [Presentation] Allowing animals to bite reverses the effects of immobilization stress on hippocampal neurotrophin expression.2009

    • Author(s)
      Saruta J, Sasaguri K, Tsukinoki K, Sato S
    • Organizer
      Iaaid-Asia 2^<nd>
    • Place of Presentation
      Tokyo, Japan
    • Related Report
      2010 Final Research Report
  • [Presentation] ヒト唾液腺におけるBDNF発現と局在2009

    • Author(s)
      近藤裕介, 猿田樹理, 椎木直人, 佐藤貞雄, 槻木恵一
    • Organizer
      第63回日本口腔科学会学術集会
    • Place of Presentation
      浜松
    • Related Report
      2009 Annual Research Report
  • [Presentation] 急性拘束ストレスは唾液腺由来血中BDNFを増加させる2008

    • Author(s)
      槻木恵一
    • Organizer
      日本ストレス学会
    • Place of Presentation
      大阪
    • Year and Date
      2008-10-31
    • Related Report
      2008 Annual Research Report
  • [Presentation] 唾液腺BDNFの病態生理学的意義についての研究・第5報:急性拘束ストレスモデルにおけるラット全身臓器のBDNFrecepter,TrkBmRNA発現の変動についての検討2008

    • Author(s)
      槻木恵一、猿田樹理、椎木直人、近藤裕介、佐藤貞雄
    • Organizer
      神奈川歯科大学学会第126回例会
    • Place of Presentation
      神奈川
    • Year and Date
      2008-06-12
    • Related Report
      2010 Final Research Report
  • [Presentation] 拘束ストレスはラット顎下腺においてBDNFのmRNAとタンパクの産生を誘導する2008

    • Author(s)
      槻木恵一
    • Organizer
      日本口腔科学会
    • Place of Presentation
      福岡
    • Year and Date
      2008-04-17
    • Related Report
      2008 Annual Research Report
  • [Presentation] 急性拘束ストレスモデルにおけるラット全身臓器のBDNF receptor、TrkB mRNA発現について(第3報)2008

    • Author(s)
      槻木恵一
    • Organizer
      日本歯科基礎医学会
    • Place of Presentation
      東京
    • Related Report
      2008 Annual Research Report
  • [Book] 歯科国歯完全攻略わかる病理組織像 第3版(東京)2011

    • Author(s)
      槻木恵一
    • Publisher
      学建書院
    • Related Report
      2010 Final Research Report
  • [Book] スタンダード口腔病態病理学2009

    • Author(s)
      槻木恵一
    • Total Pages
      298
    • Publisher
      学建書院
    • Related Report
      2009 Annual Research Report
  • [Book] 歯科国試完全攻略 わかる病理組織像2006

    • Author(s)
      槻木恵一
    • Total Pages
      165
    • Publisher
      学建書院
    • Related Report
      2010 Annual Research Report
  • [Remarks] ホームページ

    • URL

      http://www.kdcnet.ac.jp/college/byouri/index.html

    • Related Report
      2010 Final Research Report
  • [Remarks] WEB

    • URL

      http://www.kdcnet.ac.jp/college/byouri/index.html

    • Related Report
      2010 Annual Research Report

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Published: 2008-04-01   Modified: 2016-04-21  

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