The study on stressful lesion suppression mechanism of the BDNF derived from a salivary gland
| Project/Area Number |
20390467
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (B)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Morphological basic dentistry
|
|---|
| Research Institution | Kanagawa Dental College |
|---|
Principal Investigator |
TSUKINOKI Keiichi Kanagawa Dental College, 歯学部, 教授 (00298233)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
SAITO Ichiro 鶴見大学, 歯学部, 教授 (60147634)
|
|---|
| Co-Investigator(Renkei-kenkyūsha) |
SARUTA Juri 神奈川歯科大学, 歯学部, 講師 (30454151)
|
|---|
| Project Period (FY) |
2008 – 2010
|
| Project Status |
Completed (Fiscal Year 2010)
|
| Budget Amount *help |
¥19,630,000 (Direct Cost: ¥15,100,000、Indirect Cost: ¥4,530,000)
Fiscal Year 2010: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2009: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2008: ¥12,220,000 (Direct Cost: ¥9,400,000、Indirect Cost: ¥2,820,000)
|
|---|
| Keywords | 唾液腺 / BDNF / マウス / ストレス性病変 / 血漿BDNF / Tgマウス / PSPプロモーター / 血漿 / 水深拘束ストレス / TrkB / p75 / トランスジェニックマウス / ストレス / 胃潰瘍 |
|---|
| Research Abstract |
We developed the Tg mouse with high BDNF expression in the salivary gland. We manufactured the construct composed of PSP parotid gland-specific for the promoter, mouse BDNF and HA tag. Because the BDNF produced with a salivary gland is composed as the protein which an HA tag was added to as for the characteristic of this Tg mouse, it is the epoch-making Tg mouse which it is possible for intrinsic BDNF and distinction, and can prove in vivo behavior of the salivary gland production BDNF. This Tg mouse had a defense tendency for stress load.
|
Report
(4 results)
Research Products
(54 results)
