| Project/Area Number |
20390471
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Functional basic dentistry
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| Research Institution | Osaka University |
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Principal Investigator |
KAMISAKI Yoshinori Osaka University, 大学院・歯学研究科, 教授 (40116017)
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| Co-Investigator(Kenkyū-buntansha) |
WADA Koichiro 大阪大学, 大学院・歯学研究科, 准教授 (90263467)
SAEKI Makio 大阪大学, 大学院・歯学研究科, 講師 (30273692)
NAKAHARA Hirokazu 大阪大学, 大学院・歯学研究科, 准教授 (70324796)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥19,240,000 (Direct Cost: ¥14,800,000、Indirect Cost: ¥4,440,000)
Fiscal Year 2010: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2009: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2008: ¥8,840,000 (Direct Cost: ¥6,800,000、Indirect Cost: ¥2,040,000)
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| Keywords | アポトーシス / 口腔腫瘍 / Monad / 情報伝達 / R2TP複合体 / ユビキチン化 / NEMO / NF-・Ba / Reptin / 情報伝達系 / WD40リピート |
|---|
| Research Abstract |
Monad, a newly discovered protein, promotes apoptosis induced by anti-tumor agents. Monad exists as protein complex with RPAP3, PIH1D1, Reptin, and Pontin, similarly to that in yeast. In addition, cell survival or death is revealed to be regulated by the balance of these components. These results are useful for the treatment of oral tumors by predicting and potentiating the efficiency of anti-tumor agents.
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