Role of ER stress response in the oral cancer

• Project/Area Number: 20390477
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Pathobiological dentistry/Dental radiology
• Research Institution: The University of Tokyo
• Principal Investigator: NISHITOH Hideki (HIDEKI Nishitoh) 東京大学, 大学院・薬学系研究科, 特任研究員 (00332627)
• Project Period (FY): 2008 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥17,160,000 (Direct Cost: ¥13,200,000、Indirect Cost: ¥3,960,000); Fiscal Year 2011: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000); Fiscal Year 2010: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000); Fiscal Year 2009: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2008: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
• Keywords: 実験腫瘍学 / 蛋白質 / ストレス / 細胞・組織

Research Abstract

It is hypothesized that endoplasmic reticulum stress-induced apoptosis may be inhibited in cancer cells and endoplasmic reticulum stress response may be enhanced to induce the cancer cell survival. In this project, we identifies the role of endoplasmic reticulum stress-induced apoptosis and endoplasmic reticulum stress response in the oral cancer cells.

Research Products

• [Journal Article] CHOP is a multifunctional transcription factor in the ER stress response (2012)
  • Author(s): Nishitoh H.
  • Journal Title: J. Biochem Volume: 151 Pages: 217-219
• [Journal Article] CHOP is a multifunctional transcription factor in the ER stress response (2012)
  • Author(s): Nishitoh, H.
  • Journal Title: J Biochem Volume: 151 Issue: 3 Pages: 217-9
  • DOI: 10.1093/jb/mvr143
  • Peer Reviewed
• [Journal Article] Apoptosis signaling kinases : from stress response to health outcomes (2011)
  • Author(s): Takeda K., Naguro I., Nishitoh H., Matsuzawa A., Ichijo H.
  • Journal Title: Antioxid Redox Signal Volume: 15 Pages: 719-761
• [Journal Article] Apoptosis signaling kinases: from stress response to health outcomes (2011)
  • Author(s): Takeda, K., Naguro, I., Nishitoh, H., Matsuzawa, A. and Ichijo, H.
  • Journal Title: Antioxid. Redox Signal. Volume: 15 Issue: 3 Pages: 719-761
  • DOI: 10.1089/ars.2010.3392
  • Peer Reviewed
• [Journal Article] ER stress-induced cell death and inflammatory signaling : a therapeutic insight into intractable diseases (2011)
  • Author(s): Shimizu, Y., et al.
  • Journal Title: Endoplasmic Reticulum Stress and Human Disease Volume: (in press)(掲載確定)
  • Peer Reviewed
• [Journal Article] Apoptosis signaling kinases : from stress response to health outcomes (2011)
  • Author(s): Takeda, K., et al.
  • Journal Title: Antioxid. Redox Signal Volume: (in press)(掲載確定)
  • Peer Reviewed
• [Journal Article] CHIP-dependent termination of MEKK2 regulates temporal ERK activation required for proper hyperosmotic response (2010)
  • Author(s): Maruyama T., Kadowaki H., Okamoto N., Nagai A., Naguro I., Matsuzawa A., Shibuya H., Tanaka K., Murata S., Takeda K., Nishitoh H., Ichijo H.
  • Journal Title: EMBO J Volume: 29 Pages: 2501-2514
• [Journal Article] CHIP-dependent termination of MEKK2 regulates temporal ERK activation required for proper hyperosmotic response. (2010)
  • Author(s): Maruyama T., Kadowaki H., Okamoto N., Nagai A., Naguro I., Matsuzawa A., Shibuya H., Tanaka K., Murata S., Takeda K., Nishitoh H., Ichijo H.
  • Journal Title: EMBO J. 29 Pages: 2501-2514
  • Peer Reviewed
• [Journal Article] CHIP-dependent termination of MEKK2 regulates temporal ERK activation required for proper hyperosmotic response (2010)
  • Author(s): Maruyama, T., et al.
  • Journal Title: EMBO J. Volume: 29 Pages: 2501-2514
  • Peer Reviewed
• [Journal Article] ER quality control, ER stress-induced apoptosis and neurodegenerative diseases (2009)
  • Author(s): Nishitoh H., Kadowaki H., Takeda K., Ichijo H.
  • Journal Title: Protein Misfolding Disorders Pages: 94-102
• [Journal Article] USP14 inhibits ER-associated degradation via interaction with IRE1alpha (2009)
  • Author(s): Nagai A., Kadowaki H., Maruyama T., Takeda K., Nishitoh H., Ichijo H.
  • Journal Title: Biochem. Biophys. Res. Commun Volume: 379 Pages: 995-1000
• [Journal Article] ASK1 and ASK2 differentially regulate the counteracting roles of apoptosis and inflammation in tumorigenesis (2009)
  • Author(s): Iriyama T., Takeda K., Nakamura H., Morimoto Y., Kuroiwa T., Mizukami J., Umeda T., Noguchi T., Naguro I., Nishitoh H., Saegusa K., Tobiume K., Homma T., Shimada Y., Tsuda H., Aiko S., Imoto I., Inazawa J., Chida K., Kamei Y., Kozuma S., Taketani Y., Mats
  • Journal Title: EMBO J Volume: 28 Pages: 843-853
• [Journal Article] Targeting ASK1 in ER stress-related Neurodegenerative Diseases (2009)
  • Author(s): Homma K., Katagiri K., Nishitoh H., Ichijo H.
  • Journal Title: Expert Opin. Ther. Targets Volume: 13 Pages: 653-664
• [Journal Article] ER quality control, ER stress-induced apoptosis and neurodegenerative diseases. (2009)
  • Author(s): Nishitoh H., Kadowaki H., Takeda K., Ichijo H.
  • Journal Title: Protein Misfolding Disorders : A Trip into the ER. Protein Misfolding Disorders : A Trip into the ER Pages: 94-102
  • Peer Reviewed
• [Journal Article] USP14 inhibits ER-associated degradation via interaction with IRE1alpha. (2009)
  • Author(s): Nagai A., Kadowaki H., Maruyama T., Takeda K., *Nishitoh H., Ichijo H.
  • Journal Title: Biochem.Biophys.Res.Commun. 379 Pages: 995-1000
  • Peer Reviewed
• [Journal Article] ASK1 and ASK2 differentially regulate the counteracting roles of apoptosis and inflammation in tumorigenesis. (2009)
  • Author(s): Iriyama T., Takeda K., Nakamura H., Morimoto Y., Kuroiwa T., Mizukami J., Umeda T., Noguchi T., Naguro I., Nishitoh H., Saegusa K., Tobiume K., Homma T., Shimada Y., Tsuda H., Aiko S., Imoto I., Inazawa J., Chida K., Kamei Y., Kozuma S., Taketani Y., Matsuzawa A., Ichijo H
  • Journal Title: EMBO J. 28 Pages: 843-853
  • Peer Reviewed
• [Journal Article] Targeting ASK1 in ER stress-related Neurodegenerative Diseases. (2009)
  • Author(s): Homma, K., et al.
  • Journal Title: Expert Opinion on Therapeutic Targets 13 Pages: 653-664
  • Peer Reviewed
• [Journal Article] ASK1 and ASK2 differentially regulate the counteracting roles of apoptosis and inflammation in tumorieenesis. (2009)
  • Author(s): Iriyama, T., et al.
  • Journal Title: EMBO J. 28 Pages: 843-853
  • Peer Reviewed
• [Journal Article] USP14 inhibits ER-associated degradation via interaction with IRElalpha. (2009)
  • Author(s): Nagai, A., et al.
  • Journal Title: Biochem.Biophys.Res.Commun. 379 Pages: 995-1000
  • Peer Reviewed
• [Journal Article] (2009)
  • Author(s): Nishitoh, H., et al.
  • Journal Title: Protein Misfolding Disorders : A Trip into the ER(ed Hetz, C.)(Bentham Science Publishers) Pages: 94-102
• [Journal Article] ASK1 and ASK2 differentially regulate the counteracting roles of apoptosis and inflammation in tumorigenesis. (2009)
  • Author(s): Iriyama, T. etal.
  • Journal Title: EMBO J. 28 Pages: 843-853
  • Peer Reviewed
• [Journal Article] USP14 inhibits ER-associated degradation via interaction with IREIalpha. (2009)
  • Author(s): Nagai, A. et al.
  • Journal Title: Biochem. Biophys. Res. Commun 379 Pages: 995-1000
  • Peer Reviewed
• [Journal Article] ALS-linked mutant SOD1 induces ER stress-and ASK1-dependent motor neuron death by targeting Derlin-1 (2008)
  • Author(s): Nishitoh H., Kadowaki H., Nagai A., Maruyama T., Yokota T., Fukutomi H., Noguchi T., Matsuzawa A., Takeda K., Ichijo H.
  • Journal Title: Genes Dev Volume: 22 Pages: 1451-1464
• [Journal Article] ALS-linked mutant SOD1 induces ER stress- and ASK1-dependent motor neuron death by targeting Derlin-1. (2008)
  • Author(s): Nishitoh H., Kadowaki H., Nagai A., Maruyama T., Yokota T., Fukutomi H., Noguchi T., Matsuzawa A., Takeda K., Ichijo H
  • Journal Title: Genes Dev 22 Pages: 1451-1464
  • Peer Reviewed
• [Journal Article] ALS-linked mutant SOD1 induces ER stress-and ASKI-dependent motorneuron death by targeting Derlin-1. (2008)
  • Author(s): Nishitoh, H. et al.
  • Journal Title: Genes Dev. 22 Pages: 1451-1464
  • Peer Reviewed
• [Journal Article] ER stress-induced cell deathand inflammatory signaling : a therapeuticinsight into intractable diseases
  • Author(s): Shimizu Y., Naguro I., Nishitoh H., Ichijo H.
  • Journal Title: Endoplasmic Reticulum Stress and Human Disease Volume: (in press)
• [Journal Article] A novel monoclonal antibody reveals a conformational alteration shared by amyotrophic lateral sclerosis-linked SOD1 mutants
  • Author(s): Fujisawa T., Homma K., Yamaguchi N., Kadowaki H., Tsuburaya N., Naguro I., Matsuzawa A., Takeda K., Takahashi Y., Goto J., Tsuji S., Nishitoh H., Ichijo H.
  • Journal Title: Ann. Neurol Volume: (in press)
• [Journal Article] STT3B-dependent posttranslational N-glycosylation as a surveillance system for secretory protein
  • Author(s): Sato T., Sako Y., Sho M., Momohara M., Suico M. A., Shuto T., Nishitoh H., Okiyoneda T., Kokame K., Kaneko M., Taura M., Miyata M., Chosa K., Koga T., Morino-Koga S., Wada I., Kai H.
  • Journal Title: Mol. Cell Volume: (in press)
• [Presentation] 筋萎縮性側索硬化症における小胞体ストレスの役割 (2012)
  • Author(s): 西頭英起,一條秀憲
  • Organizer: 日本薬学会第131年会
  • Place of Presentation: 札幌
• [Presentation] Physiological and pathophysiological roles of ER stress triggered by the interaction of SOD1 with Derlin-1 (2011)
  • Author(s): Nishitoh H.
  • Organizer: MIT
  • Place of Presentation: Boston USA
  • Year and Date: 2011-06-17
• [Presentation] 筋萎縮性側索硬化症における小胞体ストレスの役割 (2011)
  • Author(s): 西頭英起,一條秀憲
  • Organizer: 日本薬学会第131年会
  • Place of Presentation: 静岡
  • Year and Date: 2011-03-31
• [Presentation] SOD1構造変化を介した小胞体ストレス応答の生理的・病理的意義 (2011)
  • Author(s): 西頭英起
  • Organizer: 奈良先端大学院大学
  • Place of Presentation: 奈良
  • Year and Date: 2011-01-13
• [Presentation] SOD1構造変化を介した小胞体ストレス応答の生理的・病理的意義 (2011)
  • Author(s): 西頭英起
  • Organizer: 奈良先端大学院大学セミナー
  • Place of Presentation: 奈良
  • Year and Date: 2011-01-13
• [Presentation] ALSにおける変異型SOD1に共通する毒性発揮機構 (2011)
  • Author(s): 藤澤貴央,西頭英起,一條秀憲
  • Organizer: 科研費新学術「シナプス病態」夏のワークショップ
  • Place of Presentation: 神戸
• [Presentation] 筋萎縮性側索硬化症における小胞体ストレスの役割 (2011)
  • Author(s): 西頭英起,一條秀憲
  • Organizer: 第20回日本Cell Death学会学術集会
  • Place of Presentation: 東京
• [Presentation] Physiological and pathophysiological roles of ER stress triggered by the interaction of SOD1 with Derlin-1 (2011)
  • Author(s): Nishitoh H., Yamaguchi N., Fujisawa T., Homma K., Ichijo H.
  • Organizer: FASEB Summer Research Conference, From Unfolded Proteins in the Endoplasmic Reticulum to Disease
  • Place of Presentation: Vermont USA
• [Presentation] Physiological and pathophysiological roles of ER stress triggered by the interaction of SOD1 with Derlin-1 (2011)
  • Author(s): Nishitoh, H.
  • Organizer: FASEB Summer Research Conference, From Unfolded Proteins in the Endoplasmic Reticulum to Disease
  • Place of Presentation: Vermont、USA
• [Presentation] ALSにおける変異型SOD1による小胞体ストレス誘導の分子メカニズム (2010)
  • Author(s): 西頭英起
  • Organizer: 第5回小胞体ストレス研究会
  • Place of Presentation: 東京
  • Year and Date: 2010-10-29
• [Presentation] 筋萎縮性側索硬化症における小胞体ストレスを介した運動神経細胞死の分子機構 (2010)
  • Author(s): 西頭英起,一條秀憲
  • Organizer: 第19回日本Cell Death学会学術集会
  • Place of Presentation: 名古屋
  • Year and Date: 2010-07-31
• [Presentation] 小胞体ストレスを介した疾患の分子機構 (2010)
  • Author(s): 西頭英起,一條秀憲
  • Organizer: 第2回シグナルネットワーク研究会
  • Place of Presentation: 大阪
  • Year and Date: 2010-05-14
• [Presentation] 小胞体品質管理機構とその破綻による疾患-Derlinファミリーを介した新規小胞体品質管理機構- (2010)
  • Author(s): 西頭英起
  • Organizer: 宮崎大学医学部セミナー
  • Place of Presentation: 宮崎
  • Year and Date: 2010-04-01
• [Presentation] Physiological and pathophysiological roles of ER stress triggered by the interaction of SOD1 with Derlin-1 (2010)
  • Author(s): Nishitoh H., Ichijo H.
  • Organizer: 第33回日本分子生物学会年会第83回日本生化学会大会合同大会
  • Place of Presentation: 神戸
• [Presentation] Pathophysiological roles of the interaction between SOD1 and Derlin-1 in ALS (2010)
  • Author(s): Nishitoh H., Ichijo H.
  • Organizer: The 3rd International Symposium on Protein Community
  • Place of Presentation: Nara
• [Presentation] Pathophysiological roles of the interaction between SOD1 and Derlin-1 in ALS. (2010)
  • Author(s): Nishitoh H., Ichijo H.
  • Organizer: The 3rd International Symposium on Protein Community
  • Place of Presentation: Nara
• [Presentation] Pathophysiological roles of the interaction between SOD1 and Derlin-1 in ALS (2010)
  • Author(s): Nishitoh, H., et al.
  • Organizer: The 3rd International Symposium on Protein Community
  • Place of Presentation: 奈良
• [Presentation] A common mechanism for ER stress by ALS-linked SOD1 mutations (2010)
  • Author(s): Fujisawa, T., et al.
  • Organizer: The 3rd International Symposium on Protein Community
  • Place of Presentation: 奈良
• [Presentation] A common mechanism for ER stress by ALS-linked SOD1 mutations (2010)
  • Author(s): 藤澤貴央, 他
  • Organizer: 東京大学医薬連携GCOEリトリート
  • Place of Presentation: 幕張
• [Presentation] ALSにおける変異型SOD1による小胞体ストレス誘導の分子メカニズム (2010)
  • Author(s): 藤澤貴央, 他
  • Organizer: 第33回日本分子生物学会年会第83回日本生化学会大会合同大会(BMB2010)
  • Place of Presentation: 神戸
• [Presentation] SOD1-Derlin-1結合を介した小胞体ストレスの生理的意義の解明 (2010)
  • Author(s): 本間謙吾, 他
  • Organizer: 第33回日本分子生物学会年会第83回日本生化学会大会合同大会(BMB2010)
  • Place of Presentation: 神戸
• [Presentation] Pathophysiological roles of the interaction between SOD1 and Derlin-1 in ALS (2010)
  • Author(s): Nishitoh, H., et al.
  • Organizer: 第33回日本分子生物学会年会第83回日本生化学会大会合同大会(BMB2010)
  • Place of Presentation: 神戸
• [Presentation] 小胞体品質管理機構とその破綻による疾患-Derlinファミリーを介した新規小胞体品質管理機構- (2009)
  • Author(s): 西頭英起
  • Organizer: 京都大学ウィルス研究所医科学セミナー
  • Place of Presentation: 京都
  • Year and Date: 2009-10-14
• [Presentation] Derlinファミリーを介した小胞体品質管理機構 (2009)
  • Author(s): 西頭英起
  • Organizer: 第4回小胞体ストレス研究会
  • Place of Presentation: 奈良
  • Year and Date: 2009-09-25
• [Presentation] 筋萎縮性側索硬化症における小胞体ストレス誘導性神経細胞死の分子メカニズム (2009)
  • Author(s): 西頭英起
  • Organizer: 徳島大学疾患ゲノム研究センター"ゲノム制御学セミナー"
  • Place of Presentation: 徳島
  • Year and Date: 2009-03-06
• [Presentation] Derlin family-mediated novel ER quality control system (2009)
  • Author(s): 西頭英起
  • Organizer: 熊本大学グローバルCOEリエゾンラボ研究会
  • Place of Presentation: 熊本
  • Year and Date: 2009-01-28
• [Presentation] Derlinファミリーを介した新規小胞体品質管理機構 (2009)
  • Author(s): 西頭英起
  • Organizer: 科研費特定領域「タンパク質の社会」班会議
  • Place of Presentation: 伊賀
• [Presentation] The molecular mechanism of motor neuron death in ALS (2009)
  • Author(s): Nishitoh H.
  • Organizer: BioJapan 2009 "World Business Forum"
  • Place of Presentation: 横浜
• [Presentation] MEKK2活性抑制機構の解明 (2009)
  • Author(s): 西頭英起,一條秀憲
  • Organizer: 第51回歯科基礎医学会学術大会・総会
  • Place of Presentation: 新潟
• [Presentation] 筋萎縮性側索硬化症における小胞体ストレス誘導性神経細胞死の分子機構 (2009)
  • Author(s): 西頭英起,藤澤貴央,本間謙吾,一條秀憲
  • Organizer: 第18回日本アポトーシス研究会学術集会
  • Place of Presentation: 長崎
• [Presentation] ALS-linked mutant SOD1 induces ER stress-dependent motor neuron death by targeting Derlin-1 (2009)
  • Author(s): 西頭英起,藤澤貴央,一條秀憲
  • Organizer: 東京大学医薬連携GCOE疾患のケミカルバイオロジー教育研究拠点第1回リトリート・国際シンポジウム
  • Place of Presentation: 千葉
• [Presentation] The role of ER stress triggered by the SOD1-Derlin-1 interaction in neurodegenerative diseases (2009)
  • Author(s): Nishitoh H.
  • Organizer: The 4th International Congress on Stress Responses in Biology and Medicine(Cell Stress Society International)
  • Place of Presentation: Sapporo
• [Presentation] ALS-linked mutant SOD1 induces ER stress-dependent motor neuron death by targeting Derlin-1 (2009)
  • Author(s): Nishitoh H., Fujisawa T., Homma K., Kadowaki H., Ichijo H.
  • Organizer: FASEB Summer Research Conference, From Unfolded Proteins in the Endoplasmic Reticulum to Disease
  • Place of Presentation: Vermont USA
• [Presentation] Molecular mechanism of mutant SOD1-induced motor neuron death in familial ALS (2009)
  • Author(s): Nishitoh H.
  • Organizer: International Conference "Protein Folding and Neurodegenerative Disease"
  • Place of Presentation: Kyoto
• [Presentation] The role of ER stress triggered by the SOD1-Derlin-1 interaction in neurodegenerative diseases. (2009)
  • Author(s): Nishitoh H.
  • Organizer: The 4th International Congress on Stress Responses in Biology and Medicine (Cell Stress Society International),
  • Place of Presentation: Sapporo
• [Presentation] ALS-linked mutant SOD1 induces ER stress-dependent motor neuron death by targeting Derlin-1.FASEB Summer Research Conference, (2009)
  • Author(s): Nishitoh H., Fujisawa T., Homma K., Kadowaki H., Ichijo H.
  • Organizer: From Unfolded Proteins in the Endoplasmic Reticulum to Disease
  • Place of Presentation: Vermont USA
• [Presentation] Molecular mechanism of mutant SOD1-induced motor neuron death in familial ALS.International Conference (2009)
  • Author(s): Nishitoh H.
  • Organizer: Protein Folding and Neurodegenerative Disease
  • Place of Presentation: Kyoto
• [Presentation] ALS-linked mutant SOD1 proteins induce ER stress-dependent motor neuron death by targeting Derlin-1.Keystone Symposia (2009)
  • Author(s): Fujisawa T., Fukutomi H., Kadowaki H., Nishitoh H., Ichijo H.
  • Organizer: Cell death
  • Place of Presentation: Whisler Canada
• [Presentation] The role of ER stress in ALS (2009)
  • Author(s): 西頭英起
  • Organizer: International Conference "Protein folding and neurodegenerative disease"
  • Place of Presentation: 京都
• [Presentation] ALS-linked mutant SOD1 induces ER stress-dependent motor neurondeath by targeting Derlin-1 (2009)
  • Author(s): 西頭英起, et al.
  • Organizer: FASEB
  • Place of Presentation: Vermont, USA
• [Presentation] 筋萎縮性側索硬化症における小胞体ストレス誘導性神経細胞死の分子機構 (2009)
  • Author(s): 西頭英起, 他
  • Organizer: 第8回日本アポトーシス研究会学術集会
  • Place of Presentation: 長崎
• [Presentation] MEKK2活性制御機構の解明 (2009)
  • Author(s): 西頭英起, 他
  • Organizer: 第51回歯科基礎医学会学術大会
  • Place of Presentation: 横浜
• [Presentation] 小胞体品質管理機構の破綻とコンフォメーショナル病 (2008)
  • Author(s): 西頭英起
  • Organizer: 第3回小胞体ストレス研究会
  • Place of Presentation: 岐阜
  • Year and Date: 2008-10-04
• [Presentation] 筋萎縮性側索硬化症における小胞体ストレス誘導性神経細胞死の分子機構 (2008)
  • Author(s): 西頭英起,一條秀憲
  • Organizer: 東京大学生命科学研究ネットワークシンポジウム2008
  • Place of Presentation: 東京
  • Year and Date: 2008-09-23
• [Presentation] 筋萎縮性側索硬化症における変異型SOD1とDerlin-1の結合に関する検討 (2008)
  • Author(s): 藤澤貴央,西頭英起,一條秀憲
  • Organizer: 第31回日本分子生物学会年会第81回日本生化学会大会合同大会
  • Place of Presentation: 神戸
• [Presentation] Derlin family-mediated novel ER quality control system (2008)
  • Author(s): Nishitoh H., Kadowaki H., Ichijo H.
  • Organizer: 第31回日本分子生物学会年会第81回日本生化学会大会合同大会
  • Place of Presentation: 神戸
• [Presentation] 小胞体品質管理におけるタンパク質分解の新規分子メカニズムの解明 (2008)
  • Author(s): 西頭英起
  • Organizer: 特定領域班会議「タンパク質の社会」
  • Place of Presentation: 沖縄
• [Presentation] MEKK2活性抑制機構の解明 (2008)
  • Author(s): 西頭英起,一條秀憲
  • Organizer: 第50回歯科基礎医学会学術大会・総会
  • Place of Presentation: 有明
• [Presentation] 筋萎縮性側索硬化症における小胞体ストレス誘導性神経細胞死の分子機構 (2008)
  • Author(s): 西頭英起 他
  • Organizer: 第17回日本アポト一シス研究会学術集会
  • Place of Presentation: 京都
• [Presentation] MEKK2活性制御機構の解明 (2008)
  • Author(s): 西頭英起 他
  • Organizer: 第50回歯科基礎医学会学術大会ならびに総会
  • Place of Presentation: 有明
• [Presentation] Derlin family-mediated novel ER quality control system (2008)
  • Author(s): Nishitoh, H. et al.
  • Organizer: BMB2008 第31回日本分子生物学会年会第81回日本生化学会大会合同大会
  • Place of Presentation: 神戸
• [Book] 筋萎縮性側索硬化症における亜鉛と小胞体ストレスの役割Biomedical Research on Trace Elements 23 (2012)
  • Author(s): 圓谷奈保美,本間謙吾,西頭英起,一條秀憲
• [Book] ALSにおける変異型SOD1による小胞体ストレス誘導の分子メカニズムPhama Media 29 (2011)
  • Author(s): 西頭英起
• [Book] 神経変性疾患と小胞体ストレスBio Clinica 26 (2011)
  • Author(s): 渡辺毅,一條秀憲,西頭英起
• [Book] 筋萎縮性側索硬化症における小胞体ストレスを介した運動神経細胞死.蛋白質核酸酵素54 (2009)
  • Author(s): 西頭英起,一條秀憲
• [Book] 「キーワード:蛋白質の一生」アポトーシス.蛋白質核酸酵素53 (2008)
  • Author(s): 門脇寿枝,西頭英起
• [Book] 「分子シャペロン」小胞体ストレスとアポトーシス.分子細胞治療7 (2008)
  • Author(s): 西頭英起,一條秀憲
• [Book] 筋萎縮性側索硬化症における小胞体ストレスを介した運動神経細胞死の分子メカニズム.実験医学26 (2008)
  • Author(s): 西頭英起,一條秀憲
• [Book] 「シグナル伝達2008-' 09」MAPキナーゼ経路を介したストレス応答と疾患.実験医学26 (2008)
  • Author(s): 武田弘資,西頭英起,一條秀憲
• [Book] 「細胞のタンパク質品質管理機構と心血管疾患」小胞体ストレス誘導性アポトーシスの分子メカニズム」.血管医学9 (2008)
  • Author(s): 丸山剛,西頭英起,一條秀憲
• [Book] キーワードで理解するシグナル伝達イラストマップ改訂版タンパク質の品質管理
  • Author(s): 山口奈美子,西頭英起
  • Publisher: 実験医学(in press)
• [Patent(Industrial Property Rights)] 筋萎縮性側索硬化症(ALS)の診断のための抗体 (2011)
  • Inventor(s): 西頭英起、一條秀憲
  • Industrial Property Rights Holder: 東京大学
  • Filing Date: 2011-05-13
  • Overseas
• [Patent(Industrial Property Rights)] 筋萎縮性側索硬化症(ALS)の診断のための抗体 (2010)
  • Inventor(s): 西頭英起、一條秀憲
  • Industrial Property Rights Holder: 東京大学
  • Industrial Property Number: 2010-111375
  • Filing Date: 2010-05-13
• [Patent(Industrial Property Rights)] 筋萎縮性側索硬化症(ALS)の診断のための抗体 (2010)
  • Inventor(s): 西頭英起, 他
  • Industrial Property Rights Holder: 東京大学
  • Industrial Property Number: 2010-111375
  • Filing Date: 2010-05-13