| Budget Amount *help |
¥19,370,000 (Direct Cost: ¥14,900,000、Indirect Cost: ¥4,470,000)
Fiscal Year 2010: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2009: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
Fiscal Year 2008: ¥8,190,000 (Direct Cost: ¥6,300,000、Indirect Cost: ¥1,890,000)
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| Research Abstract |
We investigated the effect of the nitric oxide (NO) donor on the antitumor activity of chemotherapeutic drugs to oral squamous cell carcinoma (OSC) cells. The antitumor effect of 5-FU to OSC cells was enhanced by the combination with NO donor, NOC-18 under both normoxic and hypoxic conditions. The growth rates of tumor xenografts implanted into the subcutaneous tissues of back of the nude mice were moderately attenuated by the treatment with 5-FU or nitroglycerin (NTG) alone and the rates were strongly reduced by the combination of 5-FU and NTG. The expression levels of HIF-1α protein and its target gene products (VEGF and GLUT-1) were significantly decreased by the combination with 5-FU and NTG. Furthermore, clinical effects of chemoradiotherapy in patients with OSC were enhanced by the combination with NTG. These results suggest that the combination with NO donor and chemotherapeutic drugs is considerable in the treatment of OSC.
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