Effects of hypoxia-targeted therapies combined with chemo-radio therapy in oral squamous cell carcinoma cells
| Project/Area Number |
20390480
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Pathobiological dentistry/Dental radiology
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| Research Institution | Kochi University |
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Principal Investigator |
YAMAMOTO Tetsuya Kochi University, 教育研究部・医療学系, 教授 (00200824)
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| Co-Investigator(Kenkyū-buntansha) |
SASABE ERI 高知大学, 教育研究部・医療学系, 助教 (40363288)
SATAKE Hidetaka 高知大学, 教育研究部・医療学系, 助教 (10304685)
UEDA Eisaku 高知大学, 教育研究部・医療学系, 講師 (10203431)
TATEISHI Yoshihisa 高知大学, 教育研究部・医療学系, 助教 (20372732)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥19,370,000 (Direct Cost: ¥14,900,000、Indirect Cost: ¥4,470,000)
Fiscal Year 2010: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2009: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
Fiscal Year 2008: ¥8,190,000 (Direct Cost: ¥6,300,000、Indirect Cost: ¥1,890,000)
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| Keywords | 低酸素 / 口腔癌 / 一酸化窒素 / 口腔扁平上皮癌 / VEGF / 5-FU / Hypoxia-inducible factor-1 / 放射線感受性 / 薬剤耐性 / 活性酸素 |
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| Research Abstract |
We investigated the effect of the nitric oxide (NO) donor on the antitumor activity of chemotherapeutic drugs to oral squamous cell carcinoma (OSC) cells. The antitumor effect of 5-FU to OSC cells was enhanced by the combination with NO donor, NOC-18 under both normoxic and hypoxic conditions. The growth rates of tumor xenografts implanted into the subcutaneous tissues of back of the nude mice were moderately attenuated by the treatment with 5-FU or nitroglycerin (NTG) alone and the rates were strongly reduced by the combination of 5-FU and NTG. The expression levels of HIF-1α protein and its target gene products (VEGF and GLUT-1) were significantly decreased by the combination with 5-FU and NTG. Furthermore, clinical effects of chemoradiotherapy in patients with OSC were enhanced by the combination with NTG. These results suggest that the combination with NO donor and chemotherapeutic drugs is considerable in the treatment of OSC.
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Report
(4 results)
Research Products
(17 results)
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[Journal Article] ビスフォスフォネート投与と関連性があると考えられた顎骨骨髄炎ならびに顎骨壊死30症例に関する追跡調査～2年後の現状について～2009
Author(s)
浦出雅裕, 田中徳昭, 嶋田淳, 柴田孝典, 古澤清文, 桐田忠昭, 山本哲也, 渡辺哲郎, 北川善政, 倉科憲治, 瀬戸宗一, 福田仁一
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Journal Title
日本口腔外科学会雑誌 55巻
Pages: 553-561
NAID
Related Report
Peer Reviewed
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