| Project/Area Number |
20390481
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Conservative dentistry
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| Research Institution | Tohoku University |
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Principal Investigator |
SASANO Takashi Tohoku University, 大学院・歯学研究科, 教授 (10125560)
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| Co-Investigator(Kenkyū-buntansha) |
SUGAWARA Yumiko 東北大学, 病院, 助教 (30235866)
SHOJI Noriaki 東北大学, 病院, 講師 (70250800)
SAKAMOTO Maya 東北大学, 病院, 講師 (90157686)
IIKUBO Masahiro 東北大学, 大学院・歯学研究科, 講師 (80302157)
SATOH Shizuko 東北大学, 大学院・歯学研究科, 助教 (60225274)
杉本 是明 東北福祉大学, 総合福祉学部, 教授 (30361158)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥7,930,000 (Direct Cost: ¥6,100,000、Indirect Cost: ¥1,830,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2008: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
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| Keywords | 歯痛 / 交感神経 / 歯髄炎 / 疼痛制御 / hnRNA遺伝子発現 / 三叉神経刺激 / HPA axis / Corticotropin releasing hormone |
|---|
| Research Abstract |
This study was designed to determine the crosstalk between sensory and sympathetic nerves in pulpitis. The sympathetic nerve fibers were demonstrated to sprout in the inflamed pulp tissues. In the second place, the P2X4 gene expression was shown to be the most suitable noticeptive marker because of its sensitive response to pain stimuli.
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