|Budget Amount *help
¥19,110,000 (Direct Cost: ¥14,700,000、Indirect Cost: ¥4,410,000)
Fiscal Year 2012: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2011: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2010: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2009: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2008: ¥8,450,000 (Direct Cost: ¥6,500,000、Indirect Cost: ¥1,950,000)
We electrophysiologically showed direction-independent gap-junctionalcommunication between odontoblasts and direction dependent gap-junction betweenodontoblasts and underneath pulpal cells for the first time. These communicationsmay form a functional syncytium in the odontoblastic layer.
So-called “the hydrodynamic theory” is based on the fluid movement in the dentinaltubules. However, their inner diameters are much larger than those in the enamel side.That is, hydrodynamic pressure could not be elevated due to this large diameter oftubules. We measured the functional space between odontoblast processes and the wallof dentinal tubules using fluorescent microspheres with different diameters andexcitation wave lengths. Small microspheres (<0.04μm) could reach the pulp. Thissmall space may contribute to the high hydrodynamic pressure that trigger actionpotentials in afferent terminals and activate mechanosensitive ion channels inodontoblast cell membrane.
Adrenergic β2 receptors are associated with bone formation. We found β2 receptorimmunoreactivity in the human odontoblastic layer. We also found theimmunoreactivity of cold sensitive TRP channels and lymphatic vessels. Thus,interactions among blood and lymphatic circulation, cold receptiveness, andsympathetic β2 receptors, and may contribute to dentinogenesis.