| Budget Amount *help |
¥19,240,000 (Direct Cost: ¥14,800,000、Indirect Cost: ¥4,440,000)
Fiscal Year 2010: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2009: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2008: ¥10,400,000 (Direct Cost: ¥8,000,000、Indirect Cost: ¥2,400,000)
|
|---|
| Research Abstract |
The aim of this study is to development of new materials and method for deep-caries treatment which is reliable and safe. First, we synthesized peptide including RGD existing in N-terminal of phosphophoryn (dentin phosphoprotein) that possesses dentin induction activity. As a carrier of phosphophoryn, we used type I collagen indicating biocompatibility in this study. As a result, peptide I was found to induce large amount of reparative dentin having high density. Therefore, it was suggested that peptide I/collagen composite may be possible to be used as a new material for deep-caries treatment.
|
