Development of new materials for caries treatment using human phosphophoryn-derived RGD-containing peptide
| Project/Area Number |
20390484
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Conservative dentistry
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| Research Institution | Health Sciences University of Hokkaido |
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Principal Investigator |
TAKASHI Saito Health Sciences University of Hokkaido, 歯学部, 教授 (40265070)
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| Co-Investigator(Kenkyū-buntansha) |
YASUDA Yoshiyuki 北海道医療大学, 歯学部, 准教授 (80405670)
ITO Shuichi 北海道医療大学, 歯学部, 講師 (50382495)
KEISUKE Handa 北海道医療大学, 歯学部, 講師 (40433429)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥19,240,000 (Direct Cost: ¥14,800,000、Indirect Cost: ¥4,440,000)
Fiscal Year 2010: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2009: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2008: ¥10,400,000 (Direct Cost: ¥8,000,000、Indirect Cost: ¥2,400,000)
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| Keywords | 保存修復学 / フォスフォフォリン / RGD / う蝕治療 / 象牙質再石灰化 / 象牙質再生 / 合成ペプチド / 覆髄処置 |
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| Research Abstract |
The aim of this study is to development of new materials and method for deep-caries treatment which is reliable and safe. First, we synthesized peptide including RGD existing in N-terminal of phosphophoryn (dentin phosphoprotein) that possesses dentin induction activity. As a carrier of phosphophoryn, we used type I collagen indicating biocompatibility in this study. As a result, peptide I was found to induce large amount of reparative dentin having high density. Therefore, it was suggested that peptide I/collagen composite may be possible to be used as a new material for deep-caries treatment.
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Report
(4 results)
Research Products
(94 results)
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[Journal Article] EDTAならびにNaOClによる根管洗浄後のSEM観察-超音波洗浄との比較-2008
Author(s)
島一也, 前田英史, 後藤康治, 畦森雅子, 安田善之, 和田尚久, 藤井慎介, 友清淳, 吉嶺嘉人, 斎藤隆史, 赤峰昭文
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Journal Title
日本歯内療法学雑誌 29(1)
Pages: 15-19
NAID
Related Report
Peer Reviewed
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