The development of non-surgical preprosthodontic bone augmentation procedure for the strategic prosthodontic treatment

• Project/Area Number: 20390490
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Prosthetic dentistry
• Research Institution: Kyushu University
• Principal Investigator: AYUKAWA Yasunori Kyushu University, 大学病院, 講師 (50304697)
• Co-Investigator(Kenkyū-buntansha): OGINO Yoichiro 九州大学, 大学病院, 助教 (50380431) ; KOYANO Kiyoshi 九州大学, 大学院・歯学研究院, 教授 (50195872) ; ATSUTA Ikiru 九州大学, 大学院・歯学研究院, 助教 (30423487)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥18,980,000 (Direct Cost: ¥14,600,000、Indirect Cost: ¥4,380,000); Fiscal Year 2010: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000); Fiscal Year 2009: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2008: ¥11,050,000 (Direct Cost: ¥8,500,000、Indirect Cost: ¥2,550,000)
• Keywords: 補綴前骨再生 / トップダウントリートメント / インプラント / トップダイントリートメント

Research Abstract

The aim of this study was to achieve preprosthodontic bone augmentation without using artificial, exogenous or autogenous bone substitute. Among several drug delivery systems, a compound consisted of atelocollagen and alpha-TCP, and poly (lactic-co-glycolic acid) (PLGA) were superior to others from the point of view of persistence and sustained-release capability of statin, a bone promotive drug. Both statin-collagen-TCP complex and statin-impregnated PLGA had a promotive effect on osteoblastic cell differentiation in vitro, and they had a bone formation capacity in rat model.

Research Products

• [Journal Article] The effect of a single remote injection of statin-impregnated poly (lactic-co-glycolic acid) microspheres on osteogenesis around titanium implants in rat tibia. (2010)
  • Author(s): Masuzaki T, Ayukawa Y, Moriyama Y, Jinno Y, Atsuta I, Ogino, Y, Koyano K.
  • Journal Title: Biomaterials 31 Pages: 3327-3334
• [Journal Article] Simvastatin enhances bone formation around titanium implants in rat tibiae. (2010)
  • Author(s): Ayukawa Y, Ogino Y, Moriyama Y, Atsuta I, Jinno Y, Kihara M, Tsukiyama Y, Koyano K.
  • Journal Title: Journal of Oral Rehabilitation 37 Pages: 123-130
• [Journal Article] Simvastatin enhances bone formation around titanium implants in rat tibiae (2010)
  • Author(s): Ayukawa Y, Ogino Y, Koyano K, 他5名
  • Journal Title: Journal of Oral Rehabilitation Volume: 37 Pages: 123-130
  • Peer Reviewed
• [Journal Article] The effect of a single remote injection of statin-impregnated poly(lactic-co-glycolic acid)microspheres on osteogenesis around titanium implants in rat tibia (2010)
  • Author(s): Masuzaki, Ayukawa, Koyano, ら
  • Journal Title: Biomaterials 31(12) Pages: 3327-3334
  • Peer Reviewed
• [Journal Article] Vertical bone augmentation with fluvastatin in an injectable delivery system : a rat study. (2009)
  • Author(s): Jinno Y, Ayukawa Y, Ogino Y, Atsuta I, Tsukiyama Y, Koyano K.
  • Journal Title: Clinical Oral Implants Research 20 Pages: 756-760
• [Presentation] 骨増生・骨再生の極近未来-bench to clinic- (2010)
  • Author(s): 鮎川保則
  • Organizer: 平成22年度日本補綴歯科学会九州支部学術講演会(招待講演)
  • Place of Presentation: 熊本市
  • Year and Date: 2010-11-27
• [Presentation] Bone engineering for dental implantology : which modalities are really potential? (2010)
  • Author(s): 鮎川保則
  • Organizer: The 6th Congress of the Asian academy of Osseointegration(招待講演)
  • Place of Presentation: Seoul, Korea
  • Year and Date: 2010-11-14
• [Presentation] Bone engineering for dental implantology : which modalities are really potential? (2010)
  • Author(s): Ayukawa Y.
  • Organizer: The 6th Congress of the Asian academy of Osseo integration
  • Place of Presentation: Seoul, Korea
  • Year and Date: 2010-11-13
• [Presentation] Single transdermal application of statinenhances bone healing around titanium implants in rats. (2009)
  • Author(s): Masuzaki T, Ayukawa Y, Moriyama Y, Tsukiyama Y, Koyano K.
  • Organizer: The 6th Biennial Meeting of Asian Academy of Prosthodontics(ポスター発表)
  • Place of Presentation: Seoul, Korea
  • Year and Date: 2009-04-25
• [Presentation] Single transdermal application of statin enhances bone healing around titanium implants in rats. (2009)
  • Author(s): Masuzaki T, Ayukawa Y, ら
  • Organizer: The 6th Biennial Meeting of Asian Academy of Prosthodontics
  • Place of Presentation: ソウル、韓国
  • Year and Date: 2009-04-25
• [Presentation] Vertical Bone Augmentation with Injectable Statin Derivery System. (2008)
  • Author(s): Jinno Y, Ayukawa Y, Ogino Y, Atsuta I, Tsukiyama Y, Koyano K.
  • Organizer: 4th Scientific Meeting of the Asian Academy of Osseointegration (AAO)(ポスター発表)
  • Place of Presentation: Hiroshima
  • Year and Date: 2008-07-19
• [Presentation] Vertical Bone Augmentation with Injectable Statin Delivery System (2008)
  • Author(s): Yohei Jinno
  • Organizer: 4th Scientific meeting of the Asian Academy of Osseointegration
  • Place of Presentation: 広島市
  • Year and Date: 2008-07-19
• [Remarks] ホームページ等
  • URL: http://www.dent.kyushu-u.ac.jp/koza/koku_kinou_shufuku/soshaku_kinou_saiken/kenkyugaiyo.html