The development of non-surgical preprosthodontic bone augmentation procedure for the strategic prosthodontic treatment
| Project/Area Number |
20390490
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Prosthetic dentistry
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| Research Institution | Kyushu University |
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Principal Investigator |
AYUKAWA Yasunori Kyushu University, 大学病院, 講師 (50304697)
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| Co-Investigator(Kenkyū-buntansha) |
OGINO Yoichiro 九州大学, 大学病院, 助教 (50380431)
KOYANO Kiyoshi 九州大学, 大学院・歯学研究院, 教授 (50195872)
ATSUTA Ikiru 九州大学, 大学院・歯学研究院, 助教 (30423487)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥18,980,000 (Direct Cost: ¥14,600,000、Indirect Cost: ¥4,380,000)
Fiscal Year 2010: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2009: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2008: ¥11,050,000 (Direct Cost: ¥8,500,000、Indirect Cost: ¥2,550,000)
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| Keywords | 補綴前骨再生 / トップダウントリートメント / インプラント / トップダイントリートメント |
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| Research Abstract |
The aim of this study was to achieve preprosthodontic bone augmentation without using artificial, exogenous or autogenous bone substitute. Among several drug delivery systems, a compound consisted of atelocollagen and alpha-TCP, and poly (lactic-co-glycolic acid) (PLGA) were superior to others from the point of view of persistence and sustained-release capability of statin, a bone promotive drug. Both statin-collagen-TCP complex and statin-impregnated PLGA had a promotive effect on osteoblastic cell differentiation in vitro, and they had a bone formation capacity in rat model.
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Report
(4 results)
Research Products
(13 results)
