Alveolar bone phenotype and their aging changes identified by collagen biochemical analysis
| Project/Area Number |
20390494
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Prosthetic dentistry
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| Research Institution | Fukuoka Dental College |
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Principal Investigator |
SATO Hironobu 福岡歯科大学, 歯学部, 教授 (00145955)
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| Co-Investigator(Kenkyū-buntansha) |
MATSUURA Takashi 福岡歯科大学, 歯学部, 准教授 (60330966)
KATAFUCHI Michitsuna 福岡歯科大学, 歯学部, 助教 (90454933)
TOKUTOMI Kentaro 福岡歯科大学, 歯学部, 助教 (20508981)
松永 興昌 福岡歯科大学, 歯学部, 講師 (50389409)
後藤 加寿子 福岡歯科大学, 歯学部, 助教 (60389418)
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| Co-Investigator(Renkei-kenkyūsha) |
SASAKI Michiko 福岡歯科大学, 歯学部, 医員 (10611460)
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| Project Period (FY) |
2008 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥19,370,000 (Direct Cost: ¥14,900,000、Indirect Cost: ¥4,470,000)
Fiscal Year 2011: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2010: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2009: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2008: ¥9,620,000 (Direct Cost: ¥7,400,000、Indirect Cost: ¥2,220,000)
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| Keywords | コラーゲン / CT / 下顎骨 / 皮質骨 / 海綿骨 / 骨量 / 骨質 / ミネラル / リジン残基の水酸化 / コラーゲン架橋 / 骨粗鬆症モデルマウス / 下顎第一大臼歯 |
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| Research Abstract |
Osteoporosis shows the decrease of bone quantity and quality. In this disease, collagen, a determinant of bone quality, declines quantitatively and qualitatively, so did even in the mandible. In the mandibles which did not have osteoporotic condition, collagen quantity and quality exhibited inter-individual variation but not dependence on bone quantity and aging. Bone quantity of the mandible exhibited variation among individuals, but did not depend on aging except for in the cortical bone in females. Collagen biochemical conditions in the mandible appear to be less related with the bone quantity, rather be closely related with the bone quality.
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Report
(6 results)
Research Products
(19 results)
