The development and application of composite functional medical device using new biodegradable magnesium alloy

• Project/Area Number: 20390496
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Dental engineering/Regenerative dentistry
• Research Institution: Tohoku University
• Principal Investigator: SHIMIZU Yoshinaka 東北大学, 大学院・歯学研究科, 助教 (30302152)
• Co-Investigator(Kenkyū-buntansha): MUKAI Toshiji 独立行政法人物質・材料研究機構, 新構造材料センター, グループリーダー (40254429) ; YAMAMOTO Akiko 独立行政法人物質・材料研究機構, 生体材料センター, グループリーダー (20343882) ; 金高 弘恭 東北大学, 大学院・医工学研究科, 准教授 (50292222)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥18,070,000 (Direct Cost: ¥13,900,000、Indirect Cost: ¥4,170,000); Fiscal Year 2010: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000); Fiscal Year 2009: ¥7,540,000 (Direct Cost: ¥5,800,000、Indirect Cost: ¥1,740,000); Fiscal Year 2008: ¥7,930,000 (Direct Cost: ¥6,100,000、Indirect Cost: ¥1,830,000)
• Keywords: マグネシウム合金 / 生体吸収性 / 骨形成 / 動物実験 / 生体吸収性材料 / 培養実験 / 生体内埋入 / マイクロCT

Research Abstract

To apply biodegradable magnesium alloy for medical device, its biocompatibility and absorption velocity were examined in vitro and in vivo. In vitro, elevated activity of alkaline phosphatase was confirmed in osteoblast by magnesium ion addition. Magnesium alloy revealed the relationship between the degradation velocity and amount of gas formation. There was no pathological change in skin and bone tissue around magnesium alloy. The newly bone formation around magnesium alloy implant was seen in vivo examination. The biocompatibility and bone formation of magnesium alloy were confirmed by these results.

Research Products

• [Journal Article] Distraction device for craniofacial plastic surgery using Ni-free Ti-based shape memory alloy (2010)
  • Author(s): Kanetaka H, Shimizu Y, Kudo T, et al
  • Journal Title: J Craniofac Surg Volume: 21 Pages: 1839-1842
  • Peer Reviewed
• [Journal Article] MPC polymer regulates fibrous tissue formation by modulating cell adhesion to the biomaterial surface (2010)
  • Author(s): Zhang Y, Kanetaka H, Sano Y, Kano M, Kudo T, Shimizu Y
  • Journal Title: Dent mater J Volume: 29 Pages: 518-528
  • NAID: 10026669640
  • Peer Reviewed
• [Journal Article] Osteogenesis by gradually expanding the interface between bone surface and periosteum enhanced by bone marrow stem cell administration in rabbit (2010)
  • Author(s): Sato K, Haruyama N, Shimizu Y, et al
  • Journal Title: Oral Surg Oral Med Oral Pathol Oral Radiol Endod Volume: 110 Pages: 32-40
  • Peer Reviewed
• [Journal Article] Medical application of magnesium and its alloys as degradable biomaterials (2010)
  • Author(s): Shimizu Y, Yamamoto A, Mukai T, Shirai Y, Kano M, Kudo T, Kanetaka H, Kikuchi M
  • Journal Title: Interface Oral Health Science 2009 Pages: 318-320
• [Presentation] 生体材料評価のためのin vivo実験-生体吸収性金属材料の評価法について- (2011)
  • Author(s): 清水良央、市川博之
  • Organizer: 日本金属学会2010年春期大会
  • Place of Presentation: 茨城県つくば市
  • Year and Date: 2011-03-29
• [Presentation] 生体吸収性を有する高強度マグネシウム合金の機械的性質 (2011)
  • Author(s): 向井敏司、山本玲子、清水良央
  • Organizer: 日本金属学会2010年春期大会
  • Place of Presentation: 茨城県つくば市
  • Year and Date: 2011-03-29
• [Presentation] The application of biodegradable membrane made of magnesium alloy to rat bone defect (2011)
  • Author(s): Shimizu Yoshinaka, Kanetaka Hiroyasu, Yamamoto Akiko, Mukai Toshiji, Sato Takumi, Kano Mitsuhiro, Kudo Tada-aki, Zhang Ye, Ichikawa Hiroyuki, Kumamoto Hiroyuki
  • Organizer: The 4th International symposium for interface oral health science
  • Place of Presentation: 宮城県仙台市
• [Presentation] The application of biodegradable membrane made of magnesium alloy to rat bone defect (2011)
  • Author(s): Shimizu Y, Kanetaka H, Yamamoto A, Mukai T, et al
  • Organizer: The 4^<th> International symposium for interface oral health science
  • Place of Presentation: 仙台市
• [Presentation] 生体材料評価のためのin vivo実験-生体吸収性金属材料の評価法について- (2010)
  • Author(s): 清水良央、市川博之
  • Organizer: 日本金属学会2010年春期大会
  • Place of Presentation: 筑波大学・つくば市
  • Year and Date: 2010-03-29
• [Presentation] 生体吸収性を有する高強度マグネシウム合金の機械的性質 (2010)
  • Author(s): 向井敏司、山本玲子、清水良央
  • Organizer: 日本金属学会2010年春期大会
  • Place of Presentation: 筑波大学・つくば市
  • Year and Date: 2010-03-29
• [Presentation] In vivo biodegradation and biocompatibility evaluation of magnesium and magnesium alloys (2009)
  • Author(s): 清水良央、山本玲子、向井敏司、白井暢子、狩野充浩、工藤忠明、金高弘恭、菊地正嘉
  • Organizer: The 3rd International Symposium for Interface Oral Health Science in Sendai
  • Place of Presentation: 宮城県仙台市
• [Presentation] 生体吸収性マグネシウム合金の生体内埋入試験による分解挙動観察 (2009)
  • Author(s): 山本玲子、清水良央、白井暢子、向井敏司
  • Organizer: 日本金属学会2009年春期大会
  • Place of Presentation: 東京
• [Presentation] In vivo biodegradation and biocompatibility evaluation of magnesium and magnesium alloys (2009)
  • Author(s): 清水良央
  • Organizer: The 3^<rd> International Symposium for Interface Oral Health Science in Sendai
  • Place of Presentation: 仙台市
• [Presentation] マグネシウム合金の生体材料応用 (2008)
  • Author(s): 清水良央、山本玲子、向井敏司、白井暢子、狩野充浩、千葉亜耶美、金高弘恭、菊地正嘉
  • Organizer: 日本実験力学会2008年次講演会
  • Place of Presentation: 北海道札幌市
• [Presentation] 生体吸収性マグネシウム合金の生体内動態に関する研究 (2008)
  • Author(s): 清水良央、山本玲子、向井敏司、白井暢子、狩野充浩、岡山啓昌、金高弘恭、菊地正嘉
  • Organizer: 第50回歯科基礎医学会
  • Place of Presentation: 東京
• [Presentation] マグネシウム合金の生体材料応用 (2008)
  • Author(s): 清水良央
  • Organizer: 日本実験力学会2008年次講演会
  • Place of Presentation: 札幌市
• [Book] Interface Oral Health Science 2009 (2010)
  • Author(s): Shimizu Yoshinaka, Yamamoto Akiko, Mukai Toshiji, Shirai Yoko, Kano Mitsuhiro, Kudo Tada-aki, Kanetaka Hiroyasu, Kikuchi Masayoshi
  • Publisher: Springer