| Budget Amount *help |
¥19,240,000 (Direct Cost: ¥14,800,000、Indirect Cost: ¥4,440,000)
Fiscal Year 2010: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2009: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2008: ¥8,710,000 (Direct Cost: ¥6,700,000、Indirect Cost: ¥2,010,000)
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| Research Abstract |
Novel bioresorbable materials with silicate and calcium ions-releasing ability for enhancing bone formation were prepared using composites consisting of siloxane, poly (lactic acid) and calcium carbonate. They could be shaped into nonwoven fibermats of 100～200μm-thickness, consisting of nanoporous fibers of～10μm in diameter. Cell culture tests showed that this dimensional design induced the 3D proliferation of bone-forming cells. The materials were confirmed by animal tests using rabbits to show excellent bone formation. They are expected to be applicable to membranes for guided bone regeneration in a dental field.
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