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Development of a light cured resin-BMP composite material intending to induce new bone formation in vivo

Research Project

Project/Area Number 20390502
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Dental engineering/Regenerative dentistry
Research InstitutionAichi Gakuin University

Principal Investigator

KAWAI Tatsushi  愛知学院大学, 歯学部, 教授 (60167351)

Co-Investigator(Kenkyū-buntansha) TSURUTA Shozou  愛知学院大学, 歯学部, 准教授 (40183488)
HAYASHI Tatsuhide  愛知学院大学, 歯学部, 講師 (70367621)
Project Period (FY) 2008 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥19,240,000 (Direct Cost: ¥14,800,000、Indirect Cost: ¥4,440,000)
Fiscal Year 2010: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2009: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2008: ¥9,620,000 (Direct Cost: ¥7,400,000、Indirect Cost: ¥2,220,000)
Keywords生体材料 / 生物・生体工学 / 再生医療 / 光造形 / biomaterial / tissue engineering / biological engineering / 3D modeling / バイオテクノロジー
Research Abstract

In order to develop an implant material that has a potential to induce new bone formation adequate to the 3-dimentional shape that refrects to each clinical situation, a resin with BMP composite was assembled. According to the 3-Dimentional data obtaining from micro X-ray CT system, resin scaffold was made by means of 3D-SLS system, then combined with BMP. The composite material was implanted in vivo and new bone formation occurred surrounding tissue of the scaffold.

Report

(4 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (52 results)

All 2011 2010 2009 2008

All Journal Article (16 results) (of which Peer Reviewed: 9 results) Presentation (33 results) Patent(Industrial Property Rights) (3 results) (of which Overseas: 1 results)

  • [Journal Article] Development of an orthodontic elastic material using EMA-based resin combined with 1-butanol2011

    • Author(s)
      Masuda, T., Miyazawa, K., Ueda, N., Hata, Y., Kawai, T., Goto, S
    • Journal Title

      Dental Materials Journal

      Volume: 30(5) Pages: 664-671

    • NAID

      10029480671

    • Related Report
      2010 Final Research Report
  • [Journal Article] Osteoanagenesis after transplantation of bone marrow-derived mesenchymal stem cells using polyvinylidene chloride film as a scaffold2011

    • Author(s)
      Hamajima, S., Hayashi, T., Sato, Y., Sasaki, K., Kawai, T
    • Journal Title

      Dental Materials Journal

      Volume: 30(5) Pages: 707-716

    • NAID

      10029480816

    • Related Report
      2010 Final Research Report
  • [Journal Article] Selected physical properties of a PEMA-based resin for possible use in a root canal filling material2011

    • Author(s)
      Wanibe, H., Yamamoto, M., Nakata, K., Kawai, T., Nakamura, H
    • Journal Title

      Dental Materials Journal

      Volume: 30(1) Pages: 52-57

    • NAID

      10027421086

    • Related Report
      2010 Final Research Report
  • [Journal Article] In vitro biocompatibility of dextrin : the addition of a low-concentration of dextrin in the medium promotes the cell activity of L929 mouse fibroblasts2011

    • Author(s)
      Asai, T., Hayashi, T., Kuroki, K., Okano, M., Kiriyama, T., Kawai, T
    • Journal Title

      Cell Biology International

      Volume: 35 Pages: 645-648

    • Related Report
      2010 Final Research Report
  • [Journal Article] Fundamental research on the mechanical properties of resin products using selective laser sintering molding2010

    • Author(s)
      Iseda, A., Ishikawa, A., Kawai, T., Sato, Y., Abe, A., Hamajima, S., Asakura, M., Mi zuno, T., Murakami, H., Hattori, M
    • Journal Title

      Aichi Gakuin Dent Sci

      Volume: 23 Pages: 1-8

    • NAID

      10031126387

    • Related Report
      2010 Final Research Report
  • [Journal Article] Human acid-insoluble dentin with BMP-2 accelerates bone induction in subcutaneous and intramuscular tissues2010

    • Author(s)
      Murata, M., Kawai, T., Kawakami, T., Akazawa, T., Tazaki, J., Ito, K., Kusano, K., Arisue, M
    • Journal Title

      Journal of the Ceramic Society of Japan

      Volume: 118(6) Pages: 438-441

    • NAID

      130000304764

    • Related Report
      2010 Final Research Report
  • [Journal Article] ISO規格とインプラントの評価基準2010

    • Author(s)
      河合達志
    • Journal Title

      日本歯科医師会雑誌

      Volume: 62(10) Pages: 1081-1089

    • Related Report
      2010 Annual Research Report
  • [Journal Article] Effect of self-cured acrylic resin added with an inorganic antibacterial agent on Streptococcus mutans.2010

    • Author(s)
      Kuroki, K., et.al.
    • Journal Title

      Dental Materials Journal

      Volume: 29(3) Pages: 277-285

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Fundamental research on the mechanical properties of resin products using selective laser sintering molding.2010

    • Author(s)
      Iseda, A., et.al.
    • Journal Title

      Aichi Gakuin Dent.Sci.

      Volume: 23 Pages: 1-8

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Human acid-insoluble dentin with BMP-2 accelerates bone induction in subcutaneous and intramuscular tissues.2010

    • Author(s)
      Murata, M., et.al.
    • Journal Title

      Journal of the Ceramic Society of Japan

      Volume: 118(6) Pages: 438-441

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cell culture in vivo by means of diffusion chamber system2009

    • Author(s)
      Nakano, K., et.al.
    • Journal Title

      Dent.Mater.J. 28(4)

      Pages: 382-387

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Application of α-tricalcium phosphate coatings on titanium subperiosteal orthodontic implants reduces the time for absolute anchorage2009

    • Author(s)
      Niwa, K., et.al
    • Journal Title

      Dent.Mater.J. 28(4)

      Pages: 477-486

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 骨形成因子-セラミック複合体の骨形成に関する基礎的研究2009

    • Author(s)
      河合秀樹
    • Journal Title

      愛院大歯誌 47(1)

      Pages: 55-62

    • NAID

      130006963633

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Histological analysis of induced cartilage on the biodegradable or nonbiodegradable membranes from immature muscular tissue in vitro2008

    • Author(s)
      Hayashi, T., et. al
    • Journal Title

      Journal of Biomedioal Materials Research Part A. 86(4)

      Pages: 1048-1054

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Mechanical properties of Newly Developed Root Canal Sealers Containing Titanium Oxide.2008

    • Author(s)
      Nakamura, A., et. al.
    • Journal Title

      Key Engineering Materials 361-363

      Pages: 845-848

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Comparison of the physical Properties of Dental Restorative Materials used in Endodontics.2008

    • Author(s)
      Watanabe, T., et. al.
    • Journal Title

      Key Engineering Materials 361-363

      Pages: 841-844

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Presentation] Osteoinductive activity of BMP-Metal composite material2011

    • Author(s)
      Ueda, N., Kawai, T., Hayashi, T., Tsuruta, S., Taniyama, M., Hamajima, S., Sato, Y., Kobayashi, S., Ohno, Y., Uematsu, Y
    • Organizer
      The international dental materials congress 2011
    • Place of Presentation
      seoul
    • Year and Date
      2011-05-29
    • Related Report
      2010 Final Research Report
  • [Presentation] Bone-like tissue induced by rhBMPs in vitro has Ossification potential in vitro2011

    • Author(s)
      Hayashi, T., Asai, T., Asakura, M., Sasaki, K., Uematsu, Y., Mieki, A., Kataoka, H., Kawai, T
    • Organizer
      The international dental materials congress 2011
    • Place of Presentation
      seoul
    • Year and Date
      2011-05-29
    • Related Report
      2010 Final Research Report
  • [Presentation] The Basic experiment about the effective of sintered titanium dioxide as a bone filling material2011

    • Author(s)
      Asai, T., Hayashi, T., Kuroki, K., Mieki, A., Kataoka, H., Kawai, T
    • Organizer
      The international dental materials congress 2011
    • Place of Presentation
      seoul
    • Year and Date
      2011-05-28
    • Related Report
      2010 Final Research Report
  • [Presentation] Surface analysis of titanium influenced by plasma glow discharge2011

    • Author(s)
      Muraji, N., Iwata, T., Kawai, T., Ueda, N., Miyazawa, K., Goto, S., Tanaka, Y
    • Organizer
      The international dental materials congress 2011
    • Place of Presentation
      seoul
    • Year and Date
      2011-05-28
    • Related Report
      2010 Final Research Report
  • [Presentation] デキストリン焼結二酸化チタン複合骨補填材の生物学的特性2010

    • Author(s)
      浅井崇文, 他
    • Organizer
      第32回日本バイオマテリアル学会大会
    • Place of Presentation
      広島
    • Year and Date
      2010-11-30
    • Related Report
      2010 Annual Research Report
  • [Presentation] PVDCフィルムを足場とした培養骨髄細胞移植による骨再生2010

    • Author(s)
      濱島聡一朗, 他
    • Organizer
      第32回日本バイオマテリアル学会大会
    • Place of Presentation
      広島
    • Year and Date
      2010-11-29
    • Related Report
      2010 Annual Research Report
  • [Presentation] 焼結二酸化チタン・デキストリン複合骨補填材の骨伝導性について2010

    • Author(s)
      浅井崇文, 他
    • Organizer
      第8回日本再生歯科医学会学術講演会
    • Place of Presentation
      名古屋
    • Year and Date
      2010-10-30
    • Related Report
      2010 Annual Research Report
  • [Presentation] ポリマー表面に銀系抗菌剤を付着処理した常温重合レジンの抗菌性2010

    • Author(s)
      桐山喬至, 他
    • Organizer
      第56回日本歯科理工学会学術講演会
    • Place of Presentation
      岐阜
    • Year and Date
      2010-10-09
    • Related Report
      2010 Annual Research Report
  • [Presentation] Application of Dextrin as a crude BMP Carrier2010

    • Author(s)
      Asai, T., Hayashi, T., Mieki, A., Kataoka, H., Hamajima, S., Kiriyama, T., Kawai, T
    • Organizer
      IADR 88th General Session Exhibition of IADR
    • Place of Presentation
      Barecelona
    • Year and Date
      2010-07-15
    • Related Report
      2010 Final Research Report
  • [Presentation] rhBMPs induce immature muscular tissue to differentiate into bone-like tissue.2010

    • Author(s)
      Hayashi, T.
    • Organizer
      88th General Session & Exhibition of IADR
    • Place of Presentation
      Barcelona
    • Year and Date
      2010-07-15
    • Related Report
      2010 Annual Research Report
  • [Presentation] Application of dextrin as a crude BMP carrier.2010

    • Author(s)
      Asai, T., et.al.
    • Organizer
      88th General Session Exhibition of IADR
    • Place of Presentation
      Barcelona
    • Year and Date
      2010-07-15
    • Related Report
      2010 Annual Research Report
  • [Presentation] rhBMPs induce immature muscular tissue to differentiate into bone-like tissue2010

    • Author(s)
      Hayashi, T., Asai, T., Mieki, A., Kataoka, H, Hamajima, S., Sato, Y., Asakura, M., Kawai, T
    • Organizer
      88th General Session & Exhibition of IADR
    • Place of Presentation
      Barecelona
    • Related Report
      2010 Final Research Report
  • [Presentation] 未成熟筋組織を用いた組織誘導 -軟骨誘導から骨誘導へ-2009

    • Author(s)
      林達秀
    • Organizer
      再生補綴医学研究会
    • Place of Presentation
      名古屋
    • Year and Date
      2009-11-27
    • Related Report
      2009 Annual Research Report
  • [Presentation] 新規開発デキストリン -二酸化チタン複合骨補填剤-2009

    • Author(s)
      浅井崇文, 他
    • Organizer
      再生補綴医学研究会
    • Place of Presentation
      名古屋
    • Year and Date
      2009-11-27
    • Related Report
      2009 Annual Research Report
  • [Presentation] PVDCフィルムを足揚とした骨髄培養細胞移植2009

    • Author(s)
      濱島総一朗, 他
    • Organizer
      第31回日本バイオマテリアル学会大会
    • Place of Presentation
      京都
    • Year and Date
      2009-11-17
    • Related Report
      2009 Annual Research Report
  • [Presentation] Mineral Trioxide Aggregate(MTA)含有接着性根管充填用シーラーの開発2009

    • Author(s)
      渡邊泰三, 他
    • Organizer
      第54回日本歯科理工学会学術講演会
    • Place of Presentation
      大阪
    • Year and Date
      2009-10-02
    • Related Report
      2009 Annual Research Report
  • [Presentation] 硬組織誘導能を有する接着性根管充填用シーラーの開発2009

    • Author(s)
      西谷佳浩, 他
    • Organizer
      第54回日本歯科理工学会学術講演会
    • Place of Presentation
      大阪
    • Year and Date
      2009-10-02
    • Related Report
      2009 Annual Research Report
  • [Presentation] 「歯科材料・器械の評価基準を考える」-ISO規格の要点-2009

    • Author(s)
      河合達志
    • Organizer
      第54回日本歯科理工学会学術講演会
    • Place of Presentation
      大阪
    • Year and Date
      2009-10-01
    • Related Report
      2009 Annual Research Report
  • [Presentation] 部分精製BMPによる新生骨誘導の長期的観察2009

    • Author(s)
      佐藤大和, 他
    • Organizer
      第54回日本歯科理工学会学術講演会
    • Place of Presentation
      大阪
    • Year and Date
      2009-10-01
    • Related Report
      2009 Annual Research Report
  • [Presentation] 二酸化チタン-デキストリン複合化新規骨補填剤の開発2009

    • Author(s)
      浅井崇文, 他
    • Organizer
      第54回日本歯科理工学会学術講演会
    • Place of Presentation
      大阪
    • Year and Date
      2009-10-01
    • Related Report
      2009 Annual Research Report
  • [Presentation] 再生治療用各種生体材料の開発について2009

    • Author(s)
      河合達志
    • Organizer
      愛知学院大学歯学会第74回学術大会
    • Place of Presentation
      名古屋
    • Year and Date
      2009-06-14
    • Related Report
      2009 Annual Research Report
  • [Presentation] 骨形成因子-セラミック複合体の骨形成に関する基礎的研究2009

    • Author(s)
      河合秀樹, 他
    • Organizer
      第53回日本歯科理工学会学術講演会
    • Place of Presentation
      東京
    • Year and Date
      2009-04-11
    • Related Report
      2009 Annual Research Report
  • [Presentation] Development of Bone Filling Material Made from the Dextrin Complex2009

    • Author(s)
      Asai T., Hayashi T., Hamajima S., Mieki A., Kataoka H., Kawai T
    • Organizer
      87th General Session & Exhibition of IADR
    • Place of Presentation
      Miami
    • Year and Date
      2009-04-04
    • Related Report
      2010 Final Research Report
  • [Presentation] Development of Bone Filling Material made from the Dextrin Complex2009

    • Author(s)
      浅井崇文, et.al
    • Organizer
      87th General Session & Exhibition of IADR
    • Place of Presentation
      Miami
    • Year and Date
      2009-04-04
    • Related Report
      2009 Annual Research Report
  • [Presentation] PVDC Film Decreases the Toxicity of Bonding Agents2009

    • Author(s)
      Hamajima S., Hayashi T., Asai T., Kataoka H., Mieki A., Kawai T
    • Organizer
      87th General Session & Exhibition of IADR
    • Place of Presentation
      Miami
    • Year and Date
      2009-04-03
    • Related Report
      2010 Final Research Report
  • [Presentation] The ossification ability of induced-bone-like tissue is promoted by Ca2+2009

    • Author(s)
      林達秀
    • Organizer
      87th General Session & Exhibition of IADR
    • Place of Presentation
      Miami
    • Year and Date
      2009-04-03
    • Related Report
      2009 Annual Research Report
  • [Presentation] PVDC film decreases the toxicity of bonding agents2009

    • Author(s)
      濱島総一朗, et.al
    • Organizer
      87th General Session & Exhibition of IADR
    • Place of Presentation
      Miami
    • Year and Date
      2009-04-03
    • Related Report
      2009 Annual Research Report
  • [Presentation] 部分精製BMPによる新生骨誘導の3次元的解析および経時的観察2008

    • Author(s)
      桶屋洋之, 他
    • Organizer
      第51回秋季日本歯周病学会学術大会
    • Place of Presentation
      四日市
    • Year and Date
      2008-10-19
    • Related Report
      2008 Annual Research Report
  • [Presentation] 生体移植用ポリエチルメタクリレートレジンの生物学的評価2008

    • Author(s)
      岡野正史, 他
    • Organizer
      第52回日本歯科理工学会学術講演会
    • Place of Presentation
      大阪
    • Year and Date
      2008-09-21
    • Related Report
      2008 Annual Research Report
  • [Presentation] PVDCフィルムの生体応用への可能性2008

    • Author(s)
      濱島聡一朗, 他
    • Organizer
      第52回日本歯科理工学会学術講演会
    • Place of Presentation
      大阪
    • Year and Date
      2008-09-21
    • Related Report
      2008 Annual Research Report
  • [Presentation] Ca2+Promotes the Calcification of Induced Bone-Like Tissue in vitro2008

    • Author(s)
      Hayashi, T., et. al.
    • Organizer
      86th General Session & Exhibition of the IADR
    • Place of Presentation
      Toronto
    • Year and Date
      2008-07-04
    • Related Report
      2008 Annual Research Report
  • [Presentation] The Influence of the Dextrin on L929 and MC3T3-E1 Cells.2008

    • Author(s)
      Asai, T., et. al.
    • Organizer
      86th General Session & Exhibition of the IADR
    • Place of Presentation
      Toronto
    • Year and Date
      2008-07-03
    • Related Report
      2008 Annual Research Report
  • [Presentation] The newly developed root canal filling materials.2008

    • Author(s)
      Wanibe, H., et. al.
    • Organizer
      56th Annual Meeting of Japanese Association for Dental Research
    • Place of Presentation
      Nagoya
    • Related Report
      2008 Annual Research Report
  • [Patent(Industrial Property Rights)] 形状記憶樹脂及びそれを用いた歯列矯正器具、並びに形状記憶樹脂の粘弾特性の制御方法2011

    • Inventor(s)
      河合達志, 他4名
    • Industrial Property Rights Holder
      河合達志, 他4名
    • Filing Date
      2011-08-08
    • Related Report
      2010 Final Research Report
  • [Patent(Industrial Property Rights)] 形状記憶樹脂及びそれを用いた歯列矯正器具、並びに形状記憶樹脂の粘弾特性の制御方法2011

    • Inventor(s)
      河合達志, 他4名
    • Industrial Property Rights Holder
      河合達志, 他4名
    • Industrial Property Number
      2011-028328
    • Filing Date
      2011-02-14
    • Related Report
      2010 Final Research Report
  • [Patent(Industrial Property Rights)] Bone filling material comprising sintered titanium dioxide and dextrin and method for reconstructing bone defects using the same2010

    • Inventor(s)
      河合達志, 他1名
    • Industrial Property Rights Holder
      愛知学院大学、松谷化学工業(株)
    • Filing Date
      2010-09-09
    • Related Report
      2010 Final Research Report
    • Overseas

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Published: 2008-04-01   Modified: 2016-04-21  

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